CNKSR2 and SHANK3

Number of citations of the paper that reports this interaction (PMID 16637659)
18

Data Source:
HPRD (in vitro)

		CNKSR2	SHANK3
Gene Name		connector enhancer of kinase suppressor of Ras 2	SH3 and multiple ankyrin repeat domains 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Neuron Projection Neuronal Cell Body Postsynaptic Membrane Extracellular Vesicular Exosome	Cytoplasm Plasma Membrane Cell Junction Neuron Projection Dendritic Spine Neuron Spine Postsynaptic Membrane Ciliary Membrane Neuronal Postsynaptic Density
	Molecular Function	Identical Protein Binding	Actin Binding Protein Binding Protein C-terminus Binding Zinc Ion Binding SH3 Domain Binding GKAP/Homer Scaffold Activity Ionotropic Glutamate Receptor Binding Identical Protein Binding Scaffold Protein Binding
	Biological Process	Regulation Of Signal Transduction	MAPK Cascade Synapse Assembly Learning Memory Striatal Medium Spiny Neuron Differentiation Adult Behavior Negative Regulation Of Actin Filament Bundle Assembly Social Behavior Vocal Learning Negative Regulation Of Cell Volume Positive Regulation Of Long-term Neuronal Synaptic Plasticity Brain Morphogenesis Positive Regulation Of Synapse Structural Plasticity Positive Regulation Of Synaptic Transmission, Glutamatergic Dendritic Spine Morphogenesis Positive Regulation Of Dendritic Spine Development Regulation Of Dendritic Spine Morphogenesis Vocalization Behavior Postsynaptic Density Assembly Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering N-methyl-D-aspartate Receptor Clustering Guanylate Kinase-associated Protein Clustering Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Glutamate Receptor Signaling Pathway Regulation Of Long Term Synaptic Depression Positive Regulation Of Excitatory Postsynaptic Membrane Potential Positive Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		12 interactors: DLG1 DLG2 DLG3 DLG4 INADL LRRC7 RALA RGS3 SHANK3 SNTA1 TJP1 TNIK	15 interactors: ABCC2 CNKSR2 COPS5 CRKL CSNK2B DLGAP1 DLGAP2 DLGAP3 DLGAP4 GRB2 MAPK1 NCK1 PAX6 PPP1CC SPTAN1
Entrez ID		22866	85358
HPRD ID		06473	18979
Ensembl ID		ENSG00000149970	ENSG00000251322
Uniprot IDs		B3KPN2 Q8WXI2	D7UT47 Q9BYB0
PDB IDs		2EAN 3BS5
Enriched GO Terms of Interacting Partners?		Receptor Localization To Synapse Receptor Clustering Protein Localization To Synapse Membrane Organization Protein Localization To Membrane Nucleotide Phosphorylation Establishment Or Maintenance Of Apical/basal Cell Polarity Cell-cell Signaling Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering Synaptic Transmission Regulation Of Membrane Potential Dendritic Spine Morphogenesis Cellular Protein Localization Vocalization Behavior Cell-cell Junction Assembly Cellular Localization Dendritic Spine Development Regulation Of Ion Transmembrane Transport Dendritic Spine Organization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Synapse Organization Cortical Actin Cytoskeleton Organization Response To External Stimulus Postsynaptic Membrane Organization Establishment Or Maintenance Of Cell Polarity Phosphorylation Cortical Cytoskeleton Organization Signaling Cellular Component Assembly Regulation Of Long-term Neuronal Synaptic Plasticity Protein Localization Cytoskeleton Organization Nucleotide Metabolic Process Cell Junction Assembly Cell Communication Cell Projection Organization Positive Regulation Of Excitatory Postsynaptic Membrane Potential Cell Morphogenesis Involved In Neuron Differentiation Cell-cell Junction Organization Chemotaxis Actin Cytoskeleton Organization Regulation Of Sodium Ion Transmembrane Transport Regulation Of Ion Transport Neuron Projection Morphogenesis Social Behavior Actin Filament-based Process Nucleobase-containing Small Molecule Metabolic Process Positive Regulation Of Membrane Potential Tight Junction Assembly Cell Morphogenesis Involved In Differentiation	Axon Guidance Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Neuron Projection Development Regulation Of Phosphorylation Cell Projection Morphogenesis Cell Part Morphogenesis Cell-cell Signaling Regulation Of Phosphorus Metabolic Process Neuron Development Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Signaling Cell Morphogenesis Neuron Differentiation Cell Projection Organization Response To External Stimulus Signaling Locomotion Cell Communication Regulation Of Signal Transduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Actin Filament Polymerization Movement Of Cell Or Subcellular Component Cellular Response To Fibroblast Growth Factor Stimulus Response To Hormone Regulation Of Cytoskeleton Organization Response To Fibroblast Growth Factor Generation Of Neurons Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Cellular Response To Insulin Stimulus Neurotrophin TRK Receptor Signaling Pathway Ras Protein Signal Transduction Neurogenesis Anatomical Structure Morphogenesis Neurotrophin Signaling Pathway Regulation Of Protein Phosphorylation Cellular Response To Hormone Stimulus Response To Organic Substance Regulation Of MAPK Cascade Positive Regulation Of Cellular Metabolic Process Cell Development
Tagcloud ?			18f 5mg amygdala antidepressant aspartate baseline biomarker bipolar blind comparative completed correlates dendritic fdg hippocampus hypothesized inability ketamine limitations mri neuroimaging pathophysiology pet predicted rearrangement spine subanesthetic tesla tethering
Tagcloud (Difference) ?			18f 5mg amygdala antidepressant aspartate baseline biomarker bipolar blind comparative completed correlates dendritic fdg hippocampus hypothesized inability ketamine limitations mri neuroimaging pathophysiology pet predicted rearrangement spine subanesthetic tesla tethering
Tagcloud (Intersection) ?