CNKSR2 and TJP1

Number of citations of the paper that reports this interaction (PMID 16637659)
18

Data Source:
HPRD (in vitro)

		CNKSR2	TJP1
Gene Name		connector enhancer of kinase suppressor of Ras 2	tight junction protein 1
Image
Gene Ontology Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Neuron Projection Neuronal Cell Body Postsynaptic Membrane Extracellular Vesicular Exosome	Nucleus Cytoplasm Cytosol Plasma Membrane Cell-cell Adherens Junction Gap Junction Tight Junction Intercalated Disc Basolateral Plasma Membrane Apical Plasma Membrane Apicolateral Plasma Membrane Cell Junction Apical Junction Complex Apical Part Of Cell Intercellular Canaliculus
	Molecular Function	Identical Protein Binding	Protein Binding Calmodulin Binding Protein C-terminus Binding Protein Domain Specific Binding
	Biological Process	Regulation Of Signal Transduction	Blastocyst Formation Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cell-cell Junction Assembly Sensory Perception Of Sound Response To Lipopolysaccharide Hippo Signaling Response To Drug Negative Regulation Of Vascular Permeability Response To Ethanol Membrane Organization Response To Magnetism Cellular Response To Glucose Stimulus Establishment Of Endothelial Intestinal Barrier Cell-cell Signaling Involved In Cell-cell Junction Organization
Pathways			Apoptotic cleavage of cell adhesion proteins c-src mediated regulation of Cx43 function and closure of gap junctions Apoptotic cleavage of cellular proteins Signaling by Hippo Gap junction trafficking and regulation Programmed Cell Death Apoptotic execution phase Regulation of gap junction activity
Drugs
Diseases
GWAS			Corneal structure ( 23291589) Response to antipsychotic treatment ( 23241943)
Protein-Protein Interactions		12 interactors: DLG1 DLG2 DLG3 DLG4 INADL LRRC7 RALA RGS3 SHANK3 SNTA1 TJP1 TNIK	38 interactors: ACTA1 ACTN4 ARVCF CGN CLDN1 CLDN16 CLDN2 CLDN3 CLDN4 CLDN5 CLDN6 CLDN7 CLDN8 CNKSR2 CTNNA1 CTTN EGFR F11R GJA1 GJA3 GJA8 GJB3 GJC1 GJD3 GRIN1 GRIN2D HSP90AA1 JAM2 JAM3 KHDRBS1 KIRREL MLLT4 PTPN14 TJP2 TJP3 TRPC4 UBN1 YBX3
Entrez ID		22866	7082
HPRD ID		06473	03002
Ensembl ID		ENSG00000149970	ENSG00000104067
Uniprot IDs		B3KPN2 Q8WXI2	G3V1L9 Q07157 Q6MZU1
PDB IDs		2EAN 3BS5	2H2B 2H2C 2H3M 2JWE 2KXR 2KXS 2RCZ 3CYY 3LH5 3SHU 3SHW 3TSV 3TSW 3TSZ
Enriched GO Terms of Interacting Partners?		Receptor Localization To Synapse Receptor Clustering Protein Localization To Synapse Membrane Organization Protein Localization To Membrane Nucleotide Phosphorylation Establishment Or Maintenance Of Apical/basal Cell Polarity Cell-cell Signaling Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering Synaptic Transmission Regulation Of Membrane Potential Dendritic Spine Morphogenesis Cellular Protein Localization Vocalization Behavior Cell-cell Junction Assembly Cellular Localization Dendritic Spine Development Regulation Of Ion Transmembrane Transport Dendritic Spine Organization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Synapse Organization Cortical Actin Cytoskeleton Organization Response To External Stimulus Postsynaptic Membrane Organization Establishment Or Maintenance Of Cell Polarity Phosphorylation Cortical Cytoskeleton Organization Signaling Cellular Component Assembly Regulation Of Long-term Neuronal Synaptic Plasticity Protein Localization Cytoskeleton Organization Nucleotide Metabolic Process Cell Junction Assembly Cell Communication Cell Projection Organization Positive Regulation Of Excitatory Postsynaptic Membrane Potential Cell Morphogenesis Involved In Neuron Differentiation Cell-cell Junction Organization Chemotaxis Actin Cytoskeleton Organization Regulation Of Sodium Ion Transmembrane Transport Regulation Of Ion Transport Neuron Projection Morphogenesis Social Behavior Actin Filament-based Process Nucleobase-containing Small Molecule Metabolic Process Positive Regulation Of Membrane Potential Tight Junction Assembly Cell Morphogenesis Involved In Differentiation	Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Cell-cell Junction Organization Cell Adhesion Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell-cell Adhesion Cell Junction Assembly Cell-cell Junction Assembly Gap Junction Assembly Cell Development Establishment Of Endothelial Intestinal Barrier Anatomical Structure Development Cellular Component Assembly Developmental Process Epithelial Cell Development Apical Junction Assembly Establishment Of Endothelial Barrier Endothelium Development Neuron Projection Development Regulation Of Body Fluid Levels Response To Abiotic Stimulus Regulation Of Actin Filament-based Process Anatomical Structure Morphogenesis Tight Junction Assembly Transmembrane Transport Endothelial Cell Development Response To Organic Substance System Development Movement Of Cell Or Subcellular Component Neuron Development Cell Differentiation Atrial Cardiac Muscle Cell Action Potential Atrial Cardiac Muscle Cell To AV Node Cell Communication Multicellular Organismal Development Locomotion Cell Communication Single Organismal Cell-cell Adhesion Epithelial Cell Differentiation Cell Morphogenesis Axon Development Endothelial Cell Differentiation Neuron Differentiation Cell-cell Signaling Involved In Cardiac Conduction Cell Projection Organization Positive Regulation Of Rap GTPase Activity Neurological System Process Establishment Of Skin Barrier Adherens Junction Organization Skin Development Neuron Projection Morphogenesis Cell-cell Signaling
Tagcloud ?			abp androgen ar blots clonal clu constitutes fshr hampering immortalized immunocytochemistry inhbb investigations loose mediators microarrays posttranslational responsiveness rhox5 sc sertoli sox9 spermatogenesis spinlw1 st38c stabilization testosterone undergoes wt1
Tagcloud (Difference) ?			abp androgen ar blots clonal clu constitutes fshr hampering immortalized immunocytochemistry inhbb investigations loose mediators microarrays posttranslational responsiveness rhox5 sc sertoli sox9 spermatogenesis spinlw1 st38c stabilization testosterone undergoes wt1
Tagcloud (Intersection) ?