Gene Name |
histone cluster 4, H4 |
nuclear receptor coactivator 2 |
Image |
|
|
Gene Ontology Annotations |
Cellular Component |
|
|
Molecular Function |
|
|
Biological Process |
|
|
Pathways |
|
- PPARA activates gene expression
- Bile acid and bile salt metabolism
- Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B)
- Organelle biogenesis and maintenance
- Metabolism of lipids and lipoproteins
- Metabolic disorders of biological oxidation enzymes
- Phase 1 - Functionalization of compounds
- Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A)
- RORA activates circadian gene expression
- Regulation of cholesterol biosynthesis by SREBP (SREBF)
- Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4)
- Generic Transcription Pathway
- Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56)
- Cytochrome P450 - arranged by substrate type
- Endogenous sterols
- Transcriptional regulation of white adipocyte differentiation
- Biological oxidations
- Synthesis of bile acids and bile salts
- Orphan transporters
- Defective FMO3 causes Trimethylaminuria (TMAU)
- Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD)
- Fatty acid, triacylglycerol, and ketone body metabolism
- Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)
- Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX)
- Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4)
- Recycling of bile acids and salts
- Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA)
- REV-ERBA represses gene expression
- Defective CYP1B1 causes Glaucoma
- Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5)
- Mitochondrial biogenesis
- Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3)
- Defective CYP19A1 causes Aromatase excess syndrome (AEXS)
- Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5)
- Defective CYP24A1 causes Hypercalcemia, infantile (HCAI)
- Synthesis of bile acids and bile salts via 27-hydroxycholesterol
- Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
- Defective MAOA causes Brunner syndrome (BRUNS)
- Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency)
- YAP1- and WWTR1 (TAZ)-stimulated gene expression
- Activation of gene expression by SREBF (SREBP)
- Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
- Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
- Transcriptional activation of mitochondrial biogenesis
- BMAL1:CLOCK,NPAS2 activates circadian gene expression
|
Drugs |
|
|
Diseases |
|
|
GWAS |
|
- Cardiac Troponin-T levels ( 23247143)
- Metabolite levels (HVA-5-HIAA Factor score) ( 23319000)
- Non-small cell lung cancer ( 23144319)
|
Protein-Protein Interactions |
52 interactors:
ANP32A
ARID4A
ASF1A
ASF1B
BRD2
BRD4
BRD7
CBX5
CDY1
COPRS
CREBBP
DAXX
DNTTIP2
EP300
GADD45A
HAT1
HDAC6
HDAC8
HDAC9
ING1
ING2
KAT2A
KAT2B
KAT6A
L3MBTL1
LRWD1
MSL3
NCOA2
NCOA3
NOC2L
NSD1
ORC2
ORC3
ORC4
ORC5
PRMT1
PRMT6
RAG1
RPS6KA5
SAP30
SET
SETD8
SETDB1
SIAH1
SMARCA5
TAF1A
TP53BP1
UBE2I
UCHL5
USP16
VHL
WDR5
|
63 interactors:
ACTN2
AHR
ANKRD11
AR
ARNT
BRCA1
CARM1
CCND3
CCNT1
CDK4
CREBBP
CTNNB1
DDX17
DDX5
DLX2
DLX5
EID1
EP300
ESR1
ESR2
ESRRB
ETV1
FOS
GMEB1
HIF1A
HIST3H3
HIST4H4
HNF4A
JUN
KIF5A
KIF5B
KIF5C
MAGEA11
MEF2C
NKX2-1
NR1I2
NR3C1
NR4A1
OPN1LW
PIAS3
PML
PPARA
PPARD
PPARG
PPFIA1
PPFIA4
PRMT1
PSMB9
RARA
RORA
RXRA
SLC30A9
SMARCE1
SRA1
SRCAP
STAT6
SUMO1
TAF9
THRB
TP53
TXNRD2
VDR
YWHAH
|
Entrez ID |
121504 |
10499 |
HPRD ID |
13662 |
09066 |
Ensembl ID |
ENSG00000197837
|
ENSG00000140396
|
Uniprot IDs |
B2R4R0
P62805
|
Q15596
|
PDB IDs |
2BQZ
2CV5
2KWN
2KWO
2LVM
2QQS
2RNY
2RS9
3A6N
3AFA
3AN2
3AV1
3AV2
3AYW
3AZE
3AZF
3AZG
3AZH
3AZI
3AZJ
3AZK
3AZL
3AZM
3AZN
3CFS
3CFV
3F9W
3F9X
3F9Y
3F9Z
3NQJ
3NQU
3O36
3QZS
3QZT
3QZV
3R45
3UVW
3UVX
3UVY
3UW9
3W96
3W97
3W98
3W99
4GQB
4H9N
4H9O
4H9P
4H9Q
4H9R
4H9S
4HGA
|
1GWQ
1GWR
1M2Z
1MV9
1MVC
1MZN
1P93
1T63
1T65
1UHL
1YOK
1ZDT
1ZDU
1ZKY
2AO6
2B1V
2B1Z
2B23
2FAI
2G44
2G5O
2P15
2P1T
2P1U
2P1V
2Q7J
2Q7L
2ZXZ
2ZY0
3A9E
3CLD
3DZU
3DZY
3E00
3E7C
3E94
3FUG
3GN8
3K22
3K23
3KWY
3KYT
3L0E
3L0J
3L0L
3O1D
3O1E
3OAP
3OZJ
3PCU
3PLZ
3Q95
3Q97
3R5M
3UP0
3UP3
4DOS
4E2J
4FHH
4FHI
4IA1
4IA2
4IA3
4IA7
4IQR
4IU7
4IUI
4IV2
4IV4
4IVW
4IVY
4IW6
4IW8
4IWC
4IWF
|
Enriched GO Terms of Interacting Partners? |
|
|
Tagcloud ? |
|
bioenergy
causally
clearer
clinicopathologies
colonize
coregulator
coregulators
decidual
decidualization
decidualize
dovetailing
endometriotic
evade
glycolytic
launch
minireview
ncoa1
ncoa3
p160
pacemaker
pathobiology
pleiotropy
proposal
quiescence
subfecundity
tantalizing
triad
underexplored
underpinning
|
Tagcloud (Difference) ? |
|
bioenergy
causally
clearer
clinicopathologies
colonize
coregulator
coregulators
decidual
decidualization
decidualize
dovetailing
endometriotic
evade
glycolytic
launch
minireview
ncoa1
ncoa3
p160
pacemaker
pathobiology
pleiotropy
proposal
quiescence
subfecundity
tantalizing
triad
underexplored
underpinning
|
Tagcloud (Intersection) ? |
|