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HIST4H4 and ASF1A
Number of citations of the paper that reports this interaction (PMID
15664198
)
71
Data Source:
BioGRID
(pull down, affinity chromatography technology)
HPRD
(in vitro)
HIST4H4
ASF1A
Gene Name
histone cluster 4, H4
anti-silencing function 1A histone chaperone
Image
Gene Ontology Annotations
Cellular Component
Nuclear Chromosome
Nucleosome
Extracellular Region
Nucleus
Nucleoplasm
Membrane
Protein Complex
Extracellular Vesicular Exosome
Nuclear Chromatin
Nucleus
Nucleoplasm
Protein Complex
Molecular Function
DNA Binding
Protein Binding
Histone Demethylase Activity (H4-K20 Specific)
Poly(A) RNA Binding
Protein Heterodimerization Activity
Chromatin Binding
Protein Binding
Histone Binding
Biological Process
Chromatin Silencing At RDNA
Mitotic Cell Cycle
Telomere Maintenance
Chromatin Organization
Nucleosome Assembly
DNA Replication-dependent Nucleosome Assembly
DNA Replication-independent Nucleosome Assembly
Gene Expression
DNA Methylation On Cytosine
CENP-A Containing Nucleosome Assembly
Histone H4-K20 Demethylation
Regulation Of Gene Expression, Epigenetic
Negative Regulation Of Megakaryocyte Differentiation
Negative Regulation Of Gene Expression, Epigenetic
Osteoblast Differentiation
DNA Repair
Nucleosome Assembly
DNA Replication-dependent Nucleosome Assembly
DNA Replication-independent Nucleosome Assembly
Transcription, DNA-templated
Chromatin Modification
Negative Regulation Of Chromatin Silencing
Muscle Cell Differentiation
Pathways
RNA Polymerase I Chain Elongation
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
Mitotic Prophase
PKMTs methylate histone lysines
Regulatory RNA pathways
RNA Polymerase I Promoter Clearance
Deposition of new CENPA-containing nucleosomes at the centromere
HDMs demethylate histones
Cellular Senescence
Signaling by Wnt
HATs acetylate histones
M Phase
Amyloids
NoRC negatively regulates rRNA expression
Packaging Of Telomere Ends
Telomere Maintenance
Nucleosome assembly
RNF mutants show enhanced WNT signaling and proliferation
XAV939 inhibits tankyrase, stabilizing AXIN
DNA methylation
Transcriptional regulation by small RNAs
Meiotic recombination
DNA Damage/Telomere Stress Induced Senescence
Chromosome Maintenance
HDACs deacetylate histones
Chromatin organization
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
RNA Polymerase I Transcription
formation of the beta-catenin:TCF transactivating complex
Meiotic synapsis
Epigenetic regulation of gene expression
Senescence-Associated Secretory Phenotype (SASP)
Negative epigenetic regulation of rRNA expression
PRC2 methylates histones and DNA
Cell Cycle, Mitotic
RMTs methylate histone arginines
Chromatin modifying enzymes
Oxidative Stress Induced Senescence
TCF dependent signaling in response to WNT
RNA Polymerase I Promoter Opening
SIRT1 negatively regulates rRNA Expression
Signaling by WNT in cancer
Condensation of Prophase Chromosomes
DNA Damage/Telomere Stress Induced Senescence
Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Cellular Senescence
Drugs
Diseases
GWAS
Pubertal anthropometrics (
23449627
)
QT interval (
19305408
)
Protein-Protein Interactions
52 interactors:
ANP32A
ARID4A
ASF1A
ASF1B
BRD2
BRD4
BRD7
CBX5
CDY1
COPRS
CREBBP
DAXX
DNTTIP2
EP300
GADD45A
HAT1
HDAC6
HDAC8
HDAC9
ING1
ING2
KAT2A
KAT2B
KAT6A
L3MBTL1
LRWD1
MSL3
NCOA2
NCOA3
NOC2L
NSD1
ORC2
ORC3
ORC4
ORC5
PRMT1
PRMT6
RAG1
RPS6KA5
SAP30
SET
SETD8
SETDB1
SIAH1
SMARCA5
TAF1A
TP53BP1
UBE2I
UCHL5
USP16
VHL
WDR5
22 interactors:
ASF1B
CDAN1
CHAF1A
CHAF1B
CHEK2
H3F3A
HIRA
HIST1H3C
HIST1H3E
HIST1H4F
HIST1H4L
HIST3H3
HIST4H4
HTATIP2
PAFAH1B2
PRR3
ST13
TAF1
TLK1
TLK2
VPS28
ZDHHC17
Entrez ID
121504
25842
HPRD ID
13662
16459
Ensembl ID
ENSG00000197837
ENSG00000111875
Uniprot IDs
B2R4R0
P62805
Q9Y294
PDB IDs
2BQZ
2CV5
2KWN
2KWO
2LVM
2QQS
2RNY
2RS9
3A6N
3AFA
3AN2
3AV1
3AV2
3AYW
3AZE
3AZF
3AZG
3AZH
3AZI
3AZJ
3AZK
3AZL
3AZM
3AZN
3CFS
3CFV
3F9W
3F9X
3F9Y
3F9Z
3NQJ
3NQU
3O36
3QZS
3QZT
3QZV
3R45
3UVW
3UVX
3UVY
3UW9
3W96
3W97
3W98
3W99
4GQB
4H9N
4H9O
4H9P
4H9Q
4H9R
4H9S
4HGA
1TEY
2I32
2IIJ
2IO5
3AAD
Enriched GO Terms of Interacting Partners
?
Chromatin Organization
Chromatin Modification
Chromosome Organization
Histone Modification
Regulation Of Gene Expression
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Peptidyl-lysine Modification
Regulation Of RNA Metabolic Process
Cellular Macromolecule Biosynthetic Process
Organelle Organization
Macromolecule Biosynthetic Process
Transcription, DNA-templated
RNA Biosynthetic Process
Nucleobase-containing Compound Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Cellular Nitrogen Compound Metabolic Process
Negative Regulation Of Gene Expression
Nitrogen Compound Metabolic Process
Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Peptidyl-amino Acid Modification
Gene Expression
RNA Metabolic Process
Negative Regulation Of Cellular Metabolic Process
Regulation Of Metabolic Process
Histone Acetylation
Internal Peptidyl-lysine Acetylation
Peptidyl-lysine Acetylation
Internal Protein Amino Acid Acetylation
Protein Acetylation
Cellular Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Cellular Protein Modification Process
Chromatin Assembly Or Disassembly
Positive Regulation Of Macromolecule Biosynthetic Process
Chromatin Assembly
Positive Regulation Of Transcription, DNA-templated
Histone H3-K9 Modification
Histone Methylation
Positive Regulation Of Gene Expression
Cell Cycle
Nucleosome Assembly
DNA Packaging
DNA Replication-dependent Nucleosome Assembly
Chromatin Assembly
Chromatin Assembly Or Disassembly
Protein-DNA Complex Assembly
DNA Packaging
Nucleosome Assembly
Nucleosome Organization
Chromatin Organization
DNA Conformation Change
Chromosome Organization
DNA Methylation On Cytosine
Chromatin Silencing At RDNA
DNA Replication-independent Nucleosome Assembly
Chromatin Silencing
Cellular Macromolecular Complex Assembly
Cellular Component Assembly
Protein Complex Assembly
DNA Methylation
Negative Regulation Of Gene Expression, Epigenetic
DNA Modification
Organelle Organization
Gene Silencing
Histone H4-K20 Demethylation
DNA Metabolic Process
Negative Regulation Of Megakaryocyte Differentiation
Regulation Of Gene Expression, Epigenetic
Chromatin Modification
Negative Regulation Of Cellular Metabolic Process
Negative Regulation Of Hematopoietic Progenitor Cell Differentiation
Telomere Maintenance
Regulation Of Megakaryocyte Differentiation
Negative Regulation Of Biosynthetic Process
Cell Cycle
Regulation Of Metabolic Process
Gene Expression
Methylation
CENP-A Containing Nucleosome Assembly
Regulation Of Hematopoietic Progenitor Cell Differentiation
Histone Exchange
Histone Lysine Demethylation
Histone Demethylation
Protein Demethylation
Regulation Of Chromatin Assembly Or Disassembly
Centromere Complex Assembly
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Demethylation
Tagcloud
?
assembled
caf
chaperone
chaperones
dissect
divergent
enhances
experiencing
h4
hira
histones
involves
mimetic
newly
nucleosomes
organization
phospho
phosphorylated
pocket
restore
shuttle
stimulating
supply
tail
timely
tlk
tlks
tousled
Tagcloud (Difference)
?
assembled
caf
chaperone
chaperones
dissect
divergent
enhances
experiencing
h4
hira
histones
involves
mimetic
newly
nucleosomes
organization
phospho
phosphorylated
pocket
restore
shuttle
stimulating
supply
tail
timely
tlk
tlks
tousled
Tagcloud (Intersection)
?