HIST4H4 and ING2

Number of citations of the paper that reports this interaction (PMID 16782091)
10

Data Source:
HPRD (in vivo)

		HIST4H4	ING2
Gene Name		histone cluster 4, H4	inhibitor of growth family, member 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromosome Nucleosome Extracellular Region Nucleus Nucleoplasm Membrane Protein Complex Extracellular Vesicular Exosome	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Sin3 Complex CCAAT-binding Factor Complex
	Molecular Function	DNA Binding Protein Binding Histone Demethylase Activity (H4-K20 Specific) Poly(A) RNA Binding Protein Heterodimerization Activity	DNA Binding Chromatin Binding Protein Binding Zinc Ion Binding Protein Complex Binding Methylated Histone Binding Phosphatidylinositol Binding
	Biological Process	Chromatin Silencing At RDNA Mitotic Cell Cycle Telomere Maintenance Chromatin Organization Nucleosome Assembly DNA Replication-dependent Nucleosome Assembly DNA Replication-independent Nucleosome Assembly Gene Expression DNA Methylation On Cytosine CENP-A Containing Nucleosome Assembly Histone H4-K20 Demethylation Regulation Of Gene Expression, Epigenetic Negative Regulation Of Megakaryocyte Differentiation Negative Regulation Of Gene Expression, Epigenetic	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Male Meiosis I Signal Transduction Spermatogenesis Spermatid Development Negative Regulation Of Cell Proliferation Chromatin Modification Sperm Motility Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Growth Positive Regulation Of Apoptotic Process Positive Regulation Of Transcription, DNA-templated Male Germ-line Stem Cell Asymmetric Division Seminiferous Tubule Development Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Cellular Senescence Regulation Of Response To DNA Damage Stimulus
Pathways		RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase PKMTs methylate histone lysines Regulatory RNA pathways RNA Polymerase I Promoter Clearance Deposition of new CENPA-containing nucleosomes at the centromere HDMs demethylate histones Cellular Senescence Signaling by Wnt HATs acetylate histones M Phase Amyloids NoRC negatively regulates rRNA expression Packaging Of Telomere Ends Telomere Maintenance Nucleosome assembly RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance HDACs deacetylate histones Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Meiotic synapsis Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression PRC2 methylates histones and DNA Cell Cycle, Mitotic RMTs methylate histone arginines Chromatin modifying enzymes Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes
Drugs
Diseases
GWAS		Pubertal anthropometrics ( 23449627)
Protein-Protein Interactions		52 interactors: ANP32A ARID4A ASF1A ASF1B BRD2 BRD4 BRD7 CBX5 CDY1 COPRS CREBBP DAXX DNTTIP2 EP300 GADD45A HAT1 HDAC6 HDAC8 HDAC9 ING1 ING2 KAT2A KAT2B KAT6A L3MBTL1 LRWD1 MSL3 NCOA2 NCOA3 NOC2L NSD1 ORC2 ORC3 ORC4 ORC5 PRMT1 PRMT6 RAG1 RPS6KA5 SAP30 SET SETD8 SETDB1 SIAH1 SMARCA5 TAF1A TP53BP1 UBE2I UCHL5 USP16 VHL WDR5	9 interactors: APP COPS2 EP300 HIST3H3 HIST4H4 SMAD1 SMURF1 SMURF2 SUMO1
Entrez ID		121504	3622
HPRD ID		13662	05021
Ensembl ID		ENSG00000197837	ENSG00000168556
Uniprot IDs		B2R4R0 P62805	Q9H160
PDB IDs		2BQZ 2CV5 2KWN 2KWO 2LVM 2QQS 2RNY 2RS9 3A6N 3AFA 3AN2 3AV1 3AV2 3AYW 3AZE 3AZF 3AZG 3AZH 3AZI 3AZJ 3AZK 3AZL 3AZM 3AZN 3CFS 3CFV 3F9W 3F9X 3F9Y 3F9Z 3NQJ 3NQU 3O36 3QZS 3QZT 3QZV 3R45 3UVW 3UVX 3UVY 3UW9 3W96 3W97 3W98 3W99 4GQB 4H9N 4H9O 4H9P 4H9Q 4H9R 4H9S 4HGA
Enriched GO Terms of Interacting Partners?		Chromatin Organization Chromatin Modification Chromosome Organization Histone Modification Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Peptidyl-lysine Modification Regulation Of RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Organelle Organization Macromolecule Biosynthetic Process Transcription, DNA-templated RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Nitrogen Compound Metabolic Process Biosynthetic Process Negative Regulation Of Biosynthetic Process Peptidyl-amino Acid Modification Gene Expression RNA Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Histone Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Protein Acetylation Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Protein Modification Process Chromatin Assembly Or Disassembly Positive Regulation Of Macromolecule Biosynthetic Process Chromatin Assembly Positive Regulation Of Transcription, DNA-templated Histone H3-K9 Modification Histone Methylation Positive Regulation Of Gene Expression Cell Cycle Nucleosome Assembly DNA Packaging	Cellular Protein Modification Process Negative Regulation Of Gene Expression Ubiquitin-dependent SMAD Protein Catabolic Process BMP Signaling Pathway Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Cellular Protein Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Negative Regulation Of Biosynthetic Process Nitrogen Compound Metabolic Process Protein Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Binding Striated Muscle Tissue Development Muscle Tissue Development Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Cellular Response To Organic Substance Cell Surface Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Telomere Maintenance Histone H2B Acetylation Cellular Metabolic Process Gene Expression Posttranscriptional Regulation Of Gene Expression Signal Transduction Regulation Of Metabolic Process Gene Silencing Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Synaptic Growth At Neuromuscular Junction Signaling Defense Response Cellular Response To Growth Factor Stimulus
Tagcloud ?			acceptor acetyltransferase alignment consensus consequently deacetylase dgcr8 e195a e3 ing1 ing1b ing3 ings isg15 k193 ligase marks mislocalized pdsm phosphomimic pias4 preferred reveals s199d stoichiometric sumo sumoylation suppressors
Tagcloud (Difference) ?			acceptor acetyltransferase alignment consensus consequently deacetylase dgcr8 e195a e3 ing1 ing1b ing3 ings isg15 k193 ligase marks mislocalized pdsm phosphomimic pias4 preferred reveals s199d stoichiometric sumo sumoylation suppressors
Tagcloud (Intersection) ?