HIST4H4 and WDR5

Number of citations of the paper that reports this interaction (PMID 24360965)
0

Data Source:
BioGRID (enzymatic study)

		HIST4H4	WDR5
Gene Name		histone cluster 4, H4	WD repeat domain 5
Image
Gene Ontology Annotations	Cellular Component	Nuclear Chromosome Nucleosome Extracellular Region Nucleus Nucleoplasm Membrane Protein Complex Extracellular Vesicular Exosome	Histone Acetyltransferase Complex Nucleus Nucleoplasm Ada2/Gcn5/Ada3 Transcription Activator Complex Histone Methyltransferase Complex Set1C/COMPASS Complex MLL1 Complex
	Molecular Function	DNA Binding Protein Binding Histone Demethylase Activity (H4-K20 Specific) Poly(A) RNA Binding Protein Heterodimerization Activity	Protein Binding Histone Methyltransferase Activity (H3-K4 Specific) Histone Acetyltransferase Activity (H4-K5 Specific) Histone Acetyltransferase Activity (H4-K8 Specific) Histone Acetyltransferase Activity (H4-K16 Specific)
	Biological Process	Chromatin Silencing At RDNA Mitotic Cell Cycle Telomere Maintenance Chromatin Organization Nucleosome Assembly DNA Replication-dependent Nucleosome Assembly DNA Replication-independent Nucleosome Assembly Gene Expression DNA Methylation On Cytosine CENP-A Containing Nucleosome Assembly Histone H4-K20 Demethylation Regulation Of Gene Expression, Epigenetic Negative Regulation Of Megakaryocyte Differentiation Negative Regulation Of Gene Expression, Epigenetic	Skeletal System Development Chromatin Organization Transcription, DNA-templated Positive Regulation Of Gluconeogenesis By Positive Regulation Of Transcription From RNA Polymerase II Promoter Histone H3 Acetylation Histone H4-K5 Acetylation Histone H4-K8 Acetylation Histone H4-K16 Acetylation Histone H3-K4 Methylation
Pathways		RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase PKMTs methylate histone lysines Regulatory RNA pathways RNA Polymerase I Promoter Clearance Deposition of new CENPA-containing nucleosomes at the centromere HDMs demethylate histones Cellular Senescence Signaling by Wnt HATs acetylate histones M Phase Amyloids NoRC negatively regulates rRNA expression Packaging Of Telomere Ends Telomere Maintenance Nucleosome assembly RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance HDACs deacetylate histones Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Meiotic synapsis Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression PRC2 methylates histones and DNA Cell Cycle, Mitotic RMTs methylate histone arginines Chromatin modifying enzymes Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes	Chromatin modifying enzymes Chromatin organization PKMTs methylate histone lysines HATs acetylate histones RMTs methylate histone arginines
Drugs
Diseases
GWAS		Pubertal anthropometrics ( 23449627)
Protein-Protein Interactions		52 interactors: ANP32A ARID4A ASF1A ASF1B BRD2 BRD4 BRD7 CBX5 CDY1 COPRS CREBBP DAXX DNTTIP2 EP300 GADD45A HAT1 HDAC6 HDAC8 HDAC9 ING1 ING2 KAT2A KAT2B KAT6A L3MBTL1 LRWD1 MSL3 NCOA2 NCOA3 NOC2L NSD1 ORC2 ORC3 ORC4 ORC5 PRMT1 PRMT6 RAG1 RPS6KA5 SAP30 SET SETD8 SETDB1 SIAH1 SMARCA5 TAF1A TP53BP1 UBE2I UCHL5 USP16 VHL WDR5	23 interactors: APP ATN1 CHD8 HIST1H1C HIST4H4 HSF2 IKBKG KMT2A KMT2B KMT2C MBIP MLLT1 POU5F1 PRMT5 PRNP RUSC1-AS1 SETD1A SETD1B SRPK2 SSX2IP TERF2IP TP53 ZXDC
Entrez ID		121504	11091
HPRD ID		13662	10614
Ensembl ID		ENSG00000197837	ENSG00000196363
Uniprot IDs		B2R4R0 P62805	P61964
PDB IDs		2BQZ 2CV5 2KWN 2KWO 2LVM 2QQS 2RNY 2RS9 3A6N 3AFA 3AN2 3AV1 3AV2 3AYW 3AZE 3AZF 3AZG 3AZH 3AZI 3AZJ 3AZK 3AZL 3AZM 3AZN 3CFS 3CFV 3F9W 3F9X 3F9Y 3F9Z 3NQJ 3NQU 3O36 3QZS 3QZT 3QZV 3R45 3UVW 3UVX 3UVY 3UW9 3W96 3W97 3W98 3W99 4GQB 4H9N 4H9O 4H9P 4H9Q 4H9R 4H9S 4HGA	2CNX 2CO0 2G99 2G9A 2GNQ 2H13 2H14 2H68 2H6K 2H6N 2H6Q 2H9L 2H9M 2H9N 2H9P 2O9K 3EG6 3EMH 3MXX 3N0D 3N0E 3P4F 3PSL 3SMR 3UR4 3UVK 3UVL 3UVM 3UVN 3UVO 4A7J 4ERQ 4ERY 4ERZ 4ES0 4ESG 4EWR 4GM3 4GM8 4IA9
Enriched GO Terms of Interacting Partners?		Chromatin Organization Chromatin Modification Chromosome Organization Histone Modification Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Peptidyl-lysine Modification Regulation Of RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Organelle Organization Macromolecule Biosynthetic Process Transcription, DNA-templated RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Nitrogen Compound Metabolic Process Biosynthetic Process Negative Regulation Of Biosynthetic Process Peptidyl-amino Acid Modification Gene Expression RNA Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Histone Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Protein Acetylation Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Protein Modification Process Chromatin Assembly Or Disassembly Positive Regulation Of Macromolecule Biosynthetic Process Chromatin Assembly Positive Regulation Of Transcription, DNA-templated Histone H3-K9 Modification Histone Methylation Positive Regulation Of Gene Expression Cell Cycle Nucleosome Assembly DNA Packaging	Gene Expression Chromatin Organization Regulation Of RNA Metabolic Process Chromosome Organization RNA Metabolic Process Transcription, DNA-templated Regulation Of Gene Expression Histone H3-K4 Methylation RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Histone Methylation Histone Modification Chromatin Modification Cellular Nitrogen Compound Metabolic Process Protein Methylation Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Histone Lysine Methylation Peptidyl-lysine Methylation Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Organelle Organization Methylation Peptidyl-lysine Modification Positive Regulation Of Gene Expression Regulation Of Chromosome Organization Positive Regulation Of Transcription, DNA-templated Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Cellular Process Negative Regulation Of Cellular Metabolic Process Peptidyl-amino Acid Modification Regulation Of Transcription From RNA Polymerase II Promoter Neuron Apoptotic Process Cellular Component Assembly Positive Regulation Of Transcription From RNA Polymerase II Promoter Neuron Death Cellular Metabolic Process Histone H3-K4 Trimethylation DNA Conformation Change Regulation Of Organelle Organization Cellular Copper Ion Homeostasis Regulation Of Fibroblast Apoptotic Process
Tagcloud ?			acidic allosterically ash2l box compass composed concave dpy30 erythroid forming heterodimer interface kmt2 lysine methyltransferase methyltransferases mll1 mutational rbbp5 referred ryanodine set1 spia spry stimulates switch trithorax trxg wrad
Tagcloud (Difference) ?			acidic allosterically ash2l box compass composed concave dpy30 erythroid forming heterodimer interface kmt2 lysine methyltransferase methyltransferases mll1 mutational rbbp5 referred ryanodine set1 spia spry stimulates switch trithorax trxg wrad
Tagcloud (Intersection) ?