H4C16 and BRD4

Number of citations of the paper that reports this interaction (PubMedID 30554943)
75

Data Source:
BioGRID (affinity chromatography technology, unspecified method)

		H4C16	BRD4
Description		H4 histone 16	bromodomain containing 4
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleosome Extracellular Region Nucleus Nucleoplasm Chromosome Membrane Protein-containing Complex CENP-A Containing Nucleosome Extracellular Exosome	Chromatin Condensed Nuclear Chromosome Nucleus Nucleoplasm Chromosome
	Molecular Function	DNA Binding RNA Binding Protein Binding Structural Constituent Of Chromatin Protein Heterodimerization Activity	Transcription Cis-regulatory Region Binding P53 Binding Chromatin Binding Transcription Coregulator Activity Transcription Coactivator Activity Protein Serine/threonine Kinase Activity Protein Binding RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Enzyme Binding Protein-macromolecule Adaptor Activity Histone Binding RNA Polymerase II C-terminal Domain Binding P-TEFb Complex Binding Histone H4 Reader Activity Histone H4K12ac Reader Activity Histone H4K5ac Reader Activity Histone H4K16ac Reader Activity Histone H4K8ac Reader Activity Histone H3K9ac Reader Activity Histone H3K27ac Reader Activity
	Biological Process	Chromatin Organization Nucleosome Assembly Telomere Organization Negative Regulation Of Megakaryocyte Differentiation Protein Localization To CENP-A Containing Chromatin	Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II DNA Damage Response Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of Canonical NF-kappaB Signal Transduction Host-mediated Suppression Of Viral Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Inflammatory Response Negative Regulation Of DNA Damage Checkpoint Positive Regulation Of T-helper 17 Cell Lineage Commitment
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones PKMTs methylate histone lysines HDMs demethylate histones HATs acetylate histones HATs acetylate histones RMTs methylate histone arginines SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression SUMOylation of chromatin organization proteins B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Deposition of new CENPA-containing nucleosomes at the centromere Assembly of the ORC complex at the origin of replication G2/M DNA damage checkpoint RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Defective pyroptosis Negative Regulation of CDH1 Gene Transcription Amyloid fiber formation Chromatin modifications during the maternal to zygotic transition (MZT) Replacement of protamines by nucleosomes in the male pronucleus MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Regulation of PD-L1(CD274) transcription	Potential therapeutics for SARS Regulation of PD-L1(CD274) transcription
Drugs
Diseases
GWAS			Immature fraction of reticulocytes ( 32888494) Mean reticulocyte volume ( 32888494) Platelet count ( 32888494) Red cell distribution width ( 32888494) Systolic blood pressure ( 30578418)
Interacting Genes		56 interacting genes: ANP32A ARID4A ASF1A ASF1B BRD2 BRD4 BRD7 CBX5 CDY1 COPRS CREBBP DAXX DNTTIP2 EP300 GADD45A HAT1 HDAC6 HDAC8 HDAC9 ING2 KAT14 KAT2A KAT2B KAT5 KAT6A KMT5A L3MBTL1 LRWD1 MSL3 NCOA2 NCOA3 NOC2L NSD1 ORC2 ORC3 ORC4 ORC5 PRMT1 PRMT5 PRMT6 RAG1 RBBP4 RPS6KA5 SAP30 SET SETDB1 SIAH1 SMARCA5 TAF1A TCF19 TP53BP1 UBE2I UCHL5 USP16 VHL WDR5	22 interacting genes: ASXL1 ASXL2 BRD9 C7orf25 C8orf33 CCNT1 CCNT2 CHFR CLDN1 COPS5 ELOB ELOC H3C14 H4C16 MESD PRPF40A RFC1 RFC4 TRIM55 TRIM63 USP17L2 VHL
Entrez ID		121504	23476
HPRD ID		13662	10574
Ensembl ID		ENSG00000197837	ENSG00000141867
Uniprot IDs		P62805	O60885
PDB IDs		1ZKK 2BQZ 2CV5 2IG0 2KWN 2KWO 2LVM 2QQS 2RJE 2RNY 2RS9 3A6N 3AFA 3AN2 3AV1 3AV2 3AYW 3AZE 3AZF 3AZG 3AZH 3AZI 3AZJ 3AZK 3AZL 3AZM 3AZN 3CFS 3CFV 3F9W 3F9X 3F9Y 3F9Z 3IJ1 3JPX 3NQJ 3NQU 3O36 3QBY 3QZS 3QZT 3QZV 3R45 3UVW 3UVX 3UVY 3UW9 3W96 3W97 3W98 3W99 3WA9 3WAA 3WKJ 3WTP 3X1S 3X1T 3X1U 3X1V 4GQB 4H9N 4H9O 4H9P 4H9Q 4H9R 4H9S 4HGA 4M38 4N3W 4N4F 4QUT 4QUU 4QYD 4U9W 4YM5 4YM6 4YY6 4YYD 4YYG 4YYH 4YYI 4YYJ 4YYK 4YYM 4YYN 4Z2M 4Z5T 5AV5 5AV6 5AV8 5AV9 5AVB 5AVC 5AY8 5B0Y 5B0Z 5B24 5B2I 5B2J 5B31 5B32 5B33 5B40 5BNV 5BNX 5BO0 5C3I 5CPI 5CPJ 5CPK 5FA5 5FFW 5FWE 5GSE 5GSU 5GT0 5GT3 5GTC 5GXQ 5JA4 5JRG 5KDM 5TEG 5X7X 5XF3 5XF4 5XF5 5Y0C 5Y0D 5YE3 5YE4 5Z23 5Z30 5ZBX 5ZGC 6A5L 6A5O 6A5P 6A5R 6A5T 6A5U 6ACP 6BUZ 6C0W 6E0C 6E0P 6FML 6HKT 6HTS 6INQ 6IR9 6J4W 6J4X 6J4Y 6J4Z 6J50 6J51 6JOU 6JR0 6JR1 6K1I 6K1J 6K1K 6KE9 6KVD 6KXV 6L49 6L4A 6L9H 6L9Z 6LA2 6LA8 6LA9 6LAB 6LE9 6LER 6M3V 6M44 6M4D 6M4G 6M4H 6MLC 6MUO 6MUP 6O1D 6R0C 6R8Y 6R8Z 6R90 6R91 6R92 6R93 6R94 6RNY 6RXS 6SE0 6SE6 6SEE 6SEF 6SEG 6T79 6T7A 6T7B 6T7C 6T7D 6T90 6T93 6UPK 6UPL 6USJ 6V2K 6V92 6VO5 6X59 6X5A 6XJD 6Y5D 6YOV 7A08 7BWD 7BXT 7BY0 7C0M 7CCQ 7CCR 7CIZ 7CJ0 7COW 7D1Z 7D20 7DBP 7E8D 7EIC 7EID 7JO9 7JOA 7JZV 7K5X 7K5Y 7K60 7K61 7K63 7LMK 7LMM 7LYA 7LYB 7LYC 7M98 7NL0 7PET 7PEU 7PEV 7PEW 7PEX 7PEY 7PEZ 7PF0 7PF2 7PF3 7PF4 7PF5 7PF6 7PFA 7PFC 7PFD 7PFE 7PFF 7PFT 7PFU 7PFV 7PFW 7PFX 7PII 7R5R 7SCY 7SCZ 7TAN 7U0G 7U0I 7U0J 7U46 7U47 7U4D 7U50 7U51 7U52 7U53 7UV9 7V1M 7V6Q 7V90 7V96 7V9C 7V9J 7V9K 7V9S 7VA4 7VCQ 7VZ4 7W9V 7WBV 7WBW 7WBX 7X57 7X58 7XCR 7XCT 7XD0 7XD1 7XSE 7XSX 7XSZ 7XT7 7XTD 7XTI 7XVL 7XVM 7XX5 7XX6 7XZX 7XZY 7XZZ 7Y00 7Y5U 7Y5V 7Y5W 7Y60 7Y61 7Y7I 7Y8R 7YOZ 7YQK 7YRD 7YWX 7YYH 7ZI4 8AAG 8ATF 8AV6 8B5A 8B5B 8B5C 8DK5 8EVG 8EVH 8EVI 8EVJ 8GRM 8GRQ 8GUI 8GUJ 8GUK 8H0V 8H0W 8H1T 8HAG 8HAH 8HAI 8HAJ 8HAK 8HAL 8HAM 8HAN 8HE5 8HLW 8HR1 8IEG 8IEJ 8IHL 8IQF 8IQG 8J6S 8J6T 8JBX 8JCC 8JCD 8JH2 8JH3 8JH4 8JHF 8JHG 8JL9 8JLA 8JLB 8JLD 8JND 8JNE 8JNF 8KB5 8KCY 8KD1 8KE0 8OFF 8OL1 8OO7 8OOA 8OOP 8OOS 8OSJ 8OSK 8OSL 8OTS 8OTT 8OX0 8OX1 8PEF 8Q36 8Q3E 8Q3M 8Q3X 8QZM 8RBX 8RGM 8SB6 8SDO 8SDQ 8SDX 8SMW 8SMX 8SMY 8SMZ 8SN0 8SN1 8SN2 8SN3 8SN4 8SN5 8SN6 8SN7 8SN8 8SN9 8SNA 8SPS 8SPU 8SYP 8TGP 8TXV 8TXW 8TXX 8U13 8U14 8UHL 8UK5 8UPF 8VFX 8VFY 8VFZ 8VG0 8VG1 8VG2 8VLR 8VMJ 8VMN 8VOB 8VWS 8VWT 8VWU 8VWV 8W9D 8W9E 8W9F 8WG5 8X15 8X19 8X1C 8X7I 8X7J 8X7K 8XBT 8XBU 8XBW 8Y3C 8Y3D 8Y3E 8Y3F 8YBJ 8YBK 8YJF 8YJM 8YNY 8YTI 8YV8 8Z50 9DWF 9DWG 9DWH 9DWI 9DWJ 9DWK 9DWL 9DWM 9EOZ 9FGQ 9FH9 9GMK 9GMR 9GXA 9IPU 9J0N 9J0O 9J0P 9J8M 9J8N 9J8O	2I8N 2LSP 2MJV 2N3K 2NCZ 2ND0 2ND1 2NNU 2OSS 2OUO 2YEL 2YEM 3MXF 3P5O 3SVF 3SVG 3U5J 3U5K 3U5L 3UVW 3UVX 3UVY 3UW9 3ZYU 4A9L 4BJX 4BW1 4BW2 4BW3 4BW4 4C66 4C67 4CFK 4CFL 4CL9 4CLB 4DON 4E96 4F3I 4GPJ 4HBV 4HBW 4HBX 4HBY 4HXK 4HXL 4HXM 4HXN 4HXO 4HXP 4HXR 4HXS 4IOO 4IOQ 4IOR 4J0R 4J0S 4J3I 4KV1 4KV4 4LR6 4LRG 4LYI 4LYS 4LYW 4LZR 4LZS 4MEN 4MEO 4MEP 4MEQ 4MR3 4MR4 4NQM 4NR8 4NUC 4NUD 4NUE 4O70 4O71 4O72 4O74 4O75 4O76 4O77 4O78 4O7A 4O7B 4O7C 4O7E 4O7F 4OGI 4OGJ 4PCE 4PCI 4PS5 4QB3 4QR3 4QR4 4QR5 4QZS 4UIX 4UIY 4UIZ 4UYD 4WHW 4WIV 4X2I 4XY9 4XYA 4YH3 4YH4 4Z1Q 4Z1S 4Z93 4ZC9 4ZW1 5A5S 5A85 5ACY 5AD2 5AD3 5BT4 5CFW 5COI 5CP5 5CPE 5CQT 5CRM 5CRZ 5CS8 5CTL 5CY9 5D0C 5D24 5D25 5D26 5D3H 5D3J 5D3L 5D3N 5D3P 5D3R 5D3S 5D3T 5DLX 5DLZ 5DW2 5DX4 5E0R 5EGU 5EI4 5EIS 5F5Z 5F60 5F61 5F62 5F63 5FBX 5H21 5HCL 5HLS 5HM0 5HQ5 5HQ6 5HQ7 5I80 5I88 5IGK 5JWM 5KDH 5KHM 5KJ0 5KU3 5LJ1 5LJ2 5LRQ 5LUU 5M39 5M3A 5MKZ 5MLI 5N2M 5NNC 5NND 5NNE 5NNF 5NNG 5O97 5OVB 5OWM 5OWW 5S9P 5S9Q 5S9R 5T35 5TI2 5TI3 5TI4 5TI5 5TI6 5TI7 5U28 5U2C 5U2E 5U2F 5UEO 5UEP 5UEQ 5UER 5UES 5UET 5UEU 5UEV 5UEX 5UEY 5UEZ 5UF0 5ULA 5UOO 5UVS 5UVT 5UVU 5UVV 5UVW 5UVX 5UVY 5UVZ 5V67 5VBO 5VBP 5VOM 5VZS 5W55 5WA5 5WMA 5WMD 5WMG 5WUU 5XHY 5XI2 5XI3 5XI4 5Y1Y 5Y8C 5Y8W 5Y8Y 5Y8Z 5Y93 5Y94 5YOU 5YOV 5YQX 5Z1R 5Z1S 5Z1T 5Z5T 5Z5U 5Z5V 5Z8G 5Z8R 5Z8Z 5Z90 5Z9C 5Z9K 6AFR 6AJV 6AJW 6AJX 6AJY 6AJZ 6BN7 6BN8 6BN9 6BNB 6BNH 6BOY 6C7Q 6C7R 6CD4 6CD5 6CIS 6CIY 6CJ1 6CJ2 6CKR 6CKS 6CZU 6CZV 6DJC 6DL2 6DMJ 6DML 6DNE 6DUV 6E4A 6FFD 6FNX 6FO5 6FSY 6FT3 6FT4 6G0D 6G0E 6G0F 6G0G 6G0H 6G0O 6G0P 6G0Q 6G0R 6G0S 6HDQ 6HOV 6I7X 6I7Y 6IN1 6JI3 6JI4 6JI5 6JJ3 6JJ5 6JJ6 6JJB 6KEC 6KED 6KEE 6KEF 6KEG 6KEH 6KEI 6KEJ 6KEK 6KO2 6LG4 6LG5 6LG6 6LG7 6LG8 6LG9 6LIH 6LIM 6MAU 6MH1 6MH7 6MNL 6P05 6PRT 6PS9 6PSB 6Q3Y 6Q3Z 6RWJ 6S25 6S4B 6S6K 6SA2 6SA3 6SAH 6SAJ 6SB8 6SE4 6SIS 6SWN 6SWQ 6TPX 6TPY 6TPZ 6U0D 6U6K 6U6L 6U72 6U74 6U8G 6U8I 6U8M 6ULS 6ULV 6UVJ 6UVM 6UWU 6UWX 6V0U 6V1K 6V1L 6V1U 6VIW 6VIX 6VIZ 6VUB 6VUC 6VUF 6VUJ 6WGX 6WVX 6WW8 6X7B 6X7C 6X7D 6XUZ 6XV3 6XV7 6XVC 6YIN 6YQN 6YQO 6YQP 6YQZ 6Z7G 6Z7L 6Z7M 6ZB3 6ZCI 6ZED 6ZEL 6ZF9 7A9U 7AJN 7AQT 7AXR 7B1T 7C2Z 7C6P 7DHS 7EHW 7EHY 7EIG 7EIK 7EIL 7FH2 7JKW 7JKX 7JKY 7JKZ 7K6G 7K6H 7KHH 7KHL 7KO0 7L9M 7LA9 7LH8 7M16 7MCE 7MCF 7MLQ 7MLR 7MLS 7MR5 7MR6 7MR7 7MR8 7MR9 7MRA 7MRB 7O18 7OEO 7P6V 7P6W 7P6Y 7Q3F 7QDL 7R5B 7R9C 7REK 7REL 7REM 7RJO 7RJP 7RJQ 7RJR 7RMD 7RN2 7RUH 7RUI 7RXR 7RXS 7RXT 7T3F 7TUQ 7TV0 7UGF 7USJ 7USK 7UTY 7UZN 7V1U 7V2J 7W3D 7WJS 7WKY 7WL4 7WWZ 7X6T 7YL2 7YMG 7YQ9 7Z9W 7Z9Y 7ZA6 7ZA7 7ZA8 7ZA9 7ZAA 7ZAD 7ZAE 7ZAJ 7ZAQ 7ZAR 7ZAT 7ZE6 7ZE7 7ZEF 7ZEN 7ZFN 7ZFO 7ZFS 7ZFT 7ZFU 7ZFV 7ZFY 7ZFZ 7ZG1 7ZG2 7ZNT 8B5B 8B5C 8B96 8B98 8BDS 8BDT 8BDX 8BEB 8C11 8CKF 8CV4 8CV6 8DYR 8E17 8E3W 8EAD 8EWV 8FVK 8G46 8GPZ 8GQ0 8IBQ 8IDH 8K14 8OV6 8P9F 8P9G 8P9H 8P9I 8P9J 8P9K 8P9L 8PIQ 8PXA 8PXM 8PXN 8Q34 8QAL 8QAN 8QAP 8QAR 8R5H 8RQ9 8RWZ 8RX0 8V9F 8WIU 8WQO 8WXY 8WY3 8WY7 8WYP 8YMB 8YME 8YMF 8YMG 8YMH 8YMI 8ZM8 8ZMB 8ZMQ 9F1J 9F1K 9F1L 9F1M 9F1N 9FBY 9FWX 9FXP
Enriched GO Terms of Interacting Partners?		Chromatin Organization Chromatin Remodeling Nucleoplasm Nucleus Histone Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Histone Acetyltransferase Activity Negative Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Chromatin Binding Protein-lysine-acetyltransferase Activity Chromosome Regulation Of Gene Expression Epigenetic Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Chromatin Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Transcription By RNA Polymerase II Transcription Coactivator Activity DNA Metabolic Process Transcription Coregulator Activity Protein Acetylation DNA-binding Transcription Factor Binding Nuclear Origin Of Replication Recognition Complex Acetyltransferase Activity Nucleosome Assembly Histone Acetyltransferase Complex Histone Reader Activity Negative Regulation Of Gene Expression, Epigenetic Nucleosome Organization Peptidyl-lysine Acetylation Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of Developmental Process Regulation Of Cellular Response To Stress Transcription Corepressor Activity	Elg1 RFC-like Complex Target-directed MiRNA Degradation Elongin Complex PR-DUB Complex DNA Replication Factor C Complex Post-translational Protein Modification Cyclin/CDK Positive Transcription Elongation Factor Complex 7SK SnRNA Binding DNA Clamp Loader Activity Protein Modification By Small Protein Conjugation Peroxisome Proliferator Activated Receptor Binding Positive Regulation Of Biosynthetic Process Nucleoplasm Cyclin-dependent Protein Serine/threonine Kinase Activator Activity MiRNA Catabolic Process Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA Negative Regulation Of MiRNA-mediated Gene Silencing Cul5-RING Ubiquitin Ligase Complex Host-mediated Activation Of Viral Transcription Cul2-RING Ubiquitin Ligase Complex Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway RNA Polymerase Binding Nucleus Positive Regulation Of Macromolecule Biosynthetic Process Protein Ubiquitination Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Elongation MiRNA Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of MiRNA-mediated Gene Silencing Regulation Of Post-transcriptional Gene Silencing Host-mediated Perturbation Of Viral Transcription Chromatin Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Transcription By RNA Polymerase II Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Interleukin-12 Receptor Activity Xenobiotic Transport Across Blood-nerve Barrier Host-mediated Activation Of Viral Process Regulation Of Macromolecule Biosynthetic Process Macromolecule Metabolic Process Macromolecule Biosynthetic Process Regulation Of Defense Response To Virus By Host Nucleobase-containing Compound Biosynthetic Process P-TEFb Complex
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?