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H4C16 and SETDB1
Number of citations of the paper that reports this interaction (PubMedID
11959841
)
41
Data Source:
BioGRID
(pull down)
H4C16
SETDB1
Description
H4 histone 16
SET domain bifurcated histone lysine methyltransferase 1
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Nucleosome
Extracellular Region
Nucleus
Nucleoplasm
Chromosome
Membrane
Protein-containing Complex
CENP-A Containing Nucleosome
Extracellular Exosome
Nucleus
Nucleoplasm
Chromosome
Cytoplasm
Molecular Function
DNA Binding
RNA Binding
Protein Binding
Structural Constituent Of Chromatin
Protein Heterodimerization Activity
DNA Binding
Chromatin Binding
Protein Binding
Methyltransferase Activity
Zinc Ion Binding
Transferase Activity
Histone Methyltransferase Activity
Metal Ion Binding
Histone H3K9 Methyltransferase Activity
Histone H3 Methyltransferase Activity
Histone H3K9me2 Methyltransferase Activity
Histone H3K9 Monomethyltransferase Activity
Histone H3K9 Trimethyltransferase Activity
Promoter-specific Chromatin Binding
Biological Process
Chromatin Organization
Nucleosome Assembly
Telomere Organization
Negative Regulation Of Megakaryocyte Differentiation
Protein Localization To CENP-A Containing Chromatin
Chromatin Organization
DNA Methylation-dependent Constitutive Heterochromatin Formation
Negative Regulation Of Gene Expression
Methylation
Heterochromatin Organization
Transposable Element Silencing By Heterochromatin Formation
Pathways
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Pre-NOTCH Transcription and Translation
Formation of the beta-catenin:TCF transactivating complex
Formation of the beta-catenin:TCF transactivating complex
PRC2 methylates histones and DNA
Condensation of Prophase Chromosomes
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
HDACs deacetylate histones
PKMTs methylate histone lysines
HDMs demethylate histones
HATs acetylate histones
HATs acetylate histones
RMTs methylate histone arginines
SIRT1 negatively regulates rRNA expression
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
NoRC negatively regulates rRNA expression
NoRC negatively regulates rRNA expression
SUMOylation of chromatin organization proteins
B-WICH complex positively regulates rRNA expression
DNA methylation
Transcriptional regulation by small RNAs
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
Deposition of new CENPA-containing nucleosomes at the centromere
Assembly of the ORC complex at the origin of replication
G2/M DNA damage checkpoint
RNA Polymerase I Promoter Opening
RNA Polymerase I Promoter Escape
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Estrogen-dependent gene expression
Meiotic recombination
HCMV Early Events
HCMV Late Events
Transcriptional regulation of granulopoiesis
Inhibition of DNA recombination at telomere
Defective pyroptosis
Negative Regulation of CDH1 Gene Transcription
Amyloid fiber formation
Chromatin modifications during the maternal to zygotic transition (MZT)
Replacement of protamines by nucleosomes in the male pronucleus
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Regulation of endogenous retroelements by KRAB-ZFP proteins
Regulation of endogenous retroelements by KRAB-ZFP proteins
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)
Regulation of PD-L1(CD274) transcription
PKMTs methylate histone lysines
Regulation of endogenous retroelements by KRAB-ZFP proteins
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex
Drugs
Diseases
GWAS
Body mass index (
26426971
)
Caffeine consumption from coffee or tea (
33287642
)
Caffeine consumption from tea (
33287642
)
Chronic kidney disease (
20383146
)
Coffee consumption (
31046077
)
Cutaneous squamous cell carcinoma (
32041948
)
Hip circumference adjusted for BMI (
34021172
)
Melanoma (
21983785
)
Neurological blood protein biomarker levels (
31320639
)
Nevus count or cutaneous melanoma (
30429480
)
Interacting Genes
56 interacting genes:
ANP32A
ARID4A
ASF1A
ASF1B
BRD2
BRD4
BRD7
CBX5
CDY1
COPRS
CREBBP
DAXX
DNTTIP2
EP300
GADD45A
HAT1
HDAC6
HDAC8
HDAC9
ING2
KAT14
KAT2A
KAT2B
KAT5
KAT6A
KMT5A
L3MBTL1
LRWD1
MSL3
NCOA2
NCOA3
NOC2L
NSD1
ORC2
ORC3
ORC4
ORC5
PRMT1
PRMT5
PRMT6
RAG1
RBBP4
RPS6KA5
SAP30
SET
SETDB1
SIAH1
SMARCA5
TAF1A
TCF19
TP53BP1
UBE2I
UCHL5
USP16
VHL
WDR5
110 interacting genes:
AIFM1
AKT1
ANXA7
APC
APLP1
ASAH1
ATF7IP
ATF7IP2
BAG6
BARD1
BHLHE40
BID
BRIX1
BTBD2
BTG3
CBX8
CCDC106
CDK4
CDKN1A
CFAP68
CLSTN1
CREBBP
CRELD1
DAP
DLEU1
DNMT3A
ECSIT
ERG
ERH
FAM118B
FLYWCH1
GIPC2
GPS2
GRB7
GSTO1
H3-4
H3C1
H3C15
H4C16
HDAC1
HDAC2
HMOX2
HSPB3
JARID2
KDM1A
LRIF1
LUC7L2
MAD2L1BP
MAP4K5
MBD1
MDM2
MOB4
MRPL44
MZT2B
NIPSNAP3A
OLFML3
ORAI2
PABPC4
PAFAH1B3
PCDHA4
PCYT2
PGAM5
PHF10
PIAS4
PLEKHA4
POLA2
PPA1
PPP1R8
PRKRA
PSMD11
PSME1
PTPRS
QTRT1
RIF1
RNF10
S100A10
SAT1
SERPINB9
SIN3A
SIN3B
SKIL
SLC38A3
SMN1
SNIP1
SUFU
SULT1E1
SUMO2
TARDBP
TCERG1
THAP8
TK1
TOB1
TOLLIP
TPI1
TRBV2
TRDMT1
TRIB3
TRIM16
TRIM28
TRIP6
TSC22D1
TTR
TXNDC9
UBE2I
ULK2
USP11
VHL
VIM
ZFP64
ZNF24
Entrez ID
121504
9869
HPRD ID
13662
06828
Ensembl ID
ENSG00000197837
ENSG00000143379
Uniprot IDs
P62805
A0A8I5KT93
Q15047
X6R732
PDB IDs
1ZKK
2BQZ
2CV5
2IG0
2KWN
2KWO
2LVM
2QQS
2RJE
2RNY
2RS9
3A6N
3AFA
3AN2
3AV1
3AV2
3AYW
3AZE
3AZF
3AZG
3AZH
3AZI
3AZJ
3AZK
3AZL
3AZM
3AZN
3CFS
3CFV
3F9W
3F9X
3F9Y
3F9Z
3IJ1
3JPX
3NQJ
3NQU
3O36
3QBY
3QZS
3QZT
3QZV
3R45
3UVW
3UVX
3UVY
3UW9
3W96
3W97
3W98
3W99
3WA9
3WAA
3WKJ
3WTP
3X1S
3X1T
3X1U
3X1V
4GQB
4H9N
4H9O
4H9P
4H9Q
4H9R
4H9S
4HGA
4M38
4N3W
4N4F
4QUT
4QUU
4QYD
4U9W
4YM5
4YM6
4YY6
4YYD
4YYG
4YYH
4YYI
4YYJ
4YYK
4YYM
4YYN
4Z2M
4Z5T
5AV5
5AV6
5AV8
5AV9
5AVB
5AVC
5AY8
5B0Y
5B0Z
5B24
5B2I
5B2J
5B31
5B32
5B33
5B40
5BNV
5BNX
5BO0
5C3I
5CPI
5CPJ
5CPK
5FA5
5FFW
5FWE
5GSE
5GSU
5GT0
5GT3
5GTC
5GXQ
5JA4
5JRG
5KDM
5TEG
5X7X
5XF3
5XF4
5XF5
5Y0C
5Y0D
5YE3
5YE4
5Z23
5Z30
5ZBX
5ZGC
6A5L
6A5O
6A5P
6A5R
6A5T
6A5U
6ACP
6BUZ
6C0W
6E0C
6E0P
6FML
6HKT
6HTS
6INQ
6IR9
6J4W
6J4X
6J4Y
6J4Z
6J50
6J51
6JOU
6JR0
6JR1
6K1I
6K1J
6K1K
6KE9
6KVD
6KXV
6L49
6L4A
6L9H
6L9Z
6LA2
6LA8
6LA9
6LAB
6LE9
6LER
6M3V
6M44
6M4D
6M4G
6M4H
6MLC
6MUO
6MUP
6O1D
6R0C
6R8Y
6R8Z
6R90
6R91
6R92
6R93
6R94
6RNY
6RXS
6SE0
6SE6
6SEE
6SEF
6SEG
6T79
6T7A
6T7B
6T7C
6T7D
6T90
6T93
6UPK
6UPL
6USJ
6V2K
6V92
6VO5
6X59
6X5A
6XJD
6Y5D
6YOV
7A08
7BWD
7BXT
7BY0
7C0M
7CCQ
7CCR
7CIZ
7CJ0
7COW
7D1Z
7D20
7DBP
7E8D
7EIC
7EID
7JO9
7JOA
7JZV
7K5X
7K5Y
7K60
7K61
7K63
7LMK
7LMM
7LYA
7LYB
7LYC
7M98
7NL0
7PET
7PEU
7PEV
7PEW
7PEX
7PEY
7PEZ
7PF0
7PF2
7PF3
7PF4
7PF5
7PF6
7PFA
7PFC
7PFD
7PFE
7PFF
7PFT
7PFU
7PFV
7PFW
7PFX
7PII
7R5R
7SCY
7SCZ
7TAN
7U0G
7U0I
7U0J
7U46
7U47
7U4D
7U50
7U51
7U52
7U53
7UV9
7V1M
7V6Q
7V90
7V96
7V9C
7V9J
7V9K
7V9S
7VA4
7VCQ
7VZ4
7W9V
7WBV
7WBW
7WBX
7X57
7X58
7XCR
7XCT
7XD0
7XD1
7XSE
7XSX
7XSZ
7XT7
7XTD
7XTI
7XVL
7XVM
7XX5
7XX6
7XZX
7XZY
7XZZ
7Y00
7Y5U
7Y5V
7Y5W
7Y60
7Y61
7Y7I
7Y8R
7YOZ
7YQK
7YRD
7YWX
7YYH
7ZI4
8AAG
8ATF
8AV6
8B5A
8B5B
8B5C
8DK5
8EVG
8EVH
8EVI
8EVJ
8GRM
8GRQ
8GUI
8GUJ
8GUK
8H0V
8H0W
8H1T
8HAG
8HAH
8HAI
8HAJ
8HAK
8HAL
8HAM
8HAN
8HE5
8HLW
8HR1
8IEG
8IEJ
8IHL
8IQF
8IQG
8J6S
8J6T
8JBX
8JCC
8JCD
8JH2
8JH3
8JH4
8JHF
8JHG
8JL9
8JLA
8JLB
8JLD
8JND
8JNE
8JNF
8KB5
8KCY
8KD1
8KE0
8OFF
8OL1
8OO7
8OOA
8OOP
8OOS
8OSJ
8OSK
8OSL
8OTS
8OTT
8OX0
8OX1
8PEF
8Q36
8Q3E
8Q3M
8Q3X
8QZM
8RBX
8RGM
8SB6
8SDO
8SDQ
8SDX
8SMW
8SMX
8SMY
8SMZ
8SN0
8SN1
8SN2
8SN3
8SN4
8SN5
8SN6
8SN7
8SN8
8SN9
8SNA
8SPS
8SPU
8SYP
8TGP
8TXV
8TXW
8TXX
8U13
8U14
8UHL
8UK5
8UPF
8VFX
8VFY
8VFZ
8VG0
8VG1
8VG2
8VLR
8VMJ
8VMN
8VOB
8VWS
8VWT
8VWU
8VWV
8W9D
8W9E
8W9F
8WG5
8X15
8X19
8X1C
8X7I
8X7J
8X7K
8XBT
8XBU
8XBW
8Y3C
8Y3D
8Y3E
8Y3F
8YBJ
8YBK
8YJF
8YJM
8YNY
8YTI
8YV8
8Z50
9DWF
9DWG
9DWH
9DWI
9DWJ
9DWK
9DWL
9DWM
9EOZ
9FGQ
9FH9
9GMK
9GMR
9GXA
9IPU
9J0N
9J0O
9J0P
9J8M
9J8N
9J8O
3DLM
4X3S
5KCH
5KCO
5KE2
5KE3
5KH6
5QT1
5QT2
6AU2
6AU3
6BHD
6BHE
6BHG
6BHH
6BHI
6BPI
7C9N
7CAJ
7CD9
7CJT
8G5E
8IYA
8UWP
9CUW
9CUX
Enriched GO Terms of Interacting Partners
?
Chromatin Organization
Chromatin Remodeling
Nucleoplasm
Nucleus
Histone Binding
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of RNA Metabolic Process
Regulation Of DNA-templated Transcription
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of RNA Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Histone Acetyltransferase Activity
Negative Regulation Of Metabolic Process
Regulation Of RNA Metabolic Process
Chromatin Binding
Protein-lysine-acetyltransferase Activity
Chromosome
Regulation Of Gene Expression
Epigenetic Regulation Of Gene Expression
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Macromolecule Metabolic Process
Chromatin
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Metabolic Process
Regulation Of Primary Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Transcription Coactivator Activity
DNA Metabolic Process
Transcription Coregulator Activity
Protein Acetylation
DNA-binding Transcription Factor Binding
Nuclear Origin Of Replication Recognition Complex
Acetyltransferase Activity
Nucleosome Assembly
Histone Acetyltransferase Complex
Histone Reader Activity
Negative Regulation Of Gene Expression, Epigenetic
Nucleosome Organization
Peptidyl-lysine Acetylation
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Biosynthetic Process
Regulation Of Developmental Process
Regulation Of Cellular Response To Stress
Transcription Corepressor Activity
Transcription Corepressor Activity
Nucleus
Nucleoplasm
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Heterochromatin Formation
Negative Regulation Of Gene Expression, Epigenetic
SUMO Transferase Activity
Regulation Of RNA Metabolic Process
Chromatin Remodeling
Epigenetic Regulation Of Gene Expression
Regulation Of Primary Metabolic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Regulation Of Cellular Response To Stress
Chromatin Organization
Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Metabolic Process
Transcription Coregulator Activity
Constitutive Heterochromatin Formation
Cytoplasm
MRF Binding
Chromatin Binding
Transcription Regulator Complex
DNA Methylation-dependent Constitutive Heterochromatin Formation
Ubiquitin Protein Ligase Binding
Sin3-type Complex
Regulation Of Mitotic Cell Cycle Phase Transition
Heterochromatin
Protein Sumoylation
Nuclear Matrix
Nuclear Body
RNA Binding
Regulation Of Intrinsic Apoptotic Signaling Pathway
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Regulation Of Proteolysis
Krueppel-associated Box Domain Binding
Enzyme Binding
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Tagcloud (Intersection)
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