HIST4H4 and COPRS

Number of citations of the paper that reports this interaction (PMID 18404153)
25

Data Source:
BioGRID (pull down)

		HIST4H4	COPRS
Gene Name		histone cluster 4, H4	coordinator of PRMT5, differentiation stimulator
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromosome Nucleosome Extracellular Region Nucleus Nucleoplasm Membrane Protein Complex Extracellular Vesicular Exosome	Nucleus Nucleoplasm Cytoplasm Plasma Membrane
	Molecular Function	DNA Binding Protein Binding Histone Demethylase Activity (H4-K20 Specific) Poly(A) RNA Binding Protein Heterodimerization Activity	Protein Binding Histone Binding
	Biological Process	Chromatin Silencing At RDNA Mitotic Cell Cycle Telomere Maintenance Chromatin Organization Nucleosome Assembly DNA Replication-dependent Nucleosome Assembly DNA Replication-independent Nucleosome Assembly Gene Expression DNA Methylation On Cytosine CENP-A Containing Nucleosome Assembly Histone H4-K20 Demethylation Regulation Of Gene Expression, Epigenetic Negative Regulation Of Megakaryocyte Differentiation Negative Regulation Of Gene Expression, Epigenetic	Chromatin Organization Transcription, DNA-templated Regulation Of Transcription, DNA-templated Muscle Organ Development Histone H4-R3 Methylation
Pathways		RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase PKMTs methylate histone lysines Regulatory RNA pathways RNA Polymerase I Promoter Clearance Deposition of new CENPA-containing nucleosomes at the centromere HDMs demethylate histones Cellular Senescence Signaling by Wnt HATs acetylate histones M Phase Amyloids NoRC negatively regulates rRNA expression Packaging Of Telomere Ends Telomere Maintenance Nucleosome assembly RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance HDACs deacetylate histones Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Meiotic synapsis Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression PRC2 methylates histones and DNA Cell Cycle, Mitotic RMTs methylate histone arginines Chromatin modifying enzymes Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes	Chromatin modifying enzymes Chromatin organization RMTs methylate histone arginines
Drugs
Diseases
GWAS		Pubertal anthropometrics ( 23449627)
Protein-Protein Interactions		52 interactors: ANP32A ARID4A ASF1A ASF1B BRD2 BRD4 BRD7 CBX5 CDY1 COPRS CREBBP DAXX DNTTIP2 EP300 GADD45A HAT1 HDAC6 HDAC8 HDAC9 ING1 ING2 KAT2A KAT2B KAT6A L3MBTL1 LRWD1 MSL3 NCOA2 NCOA3 NOC2L NSD1 ORC2 ORC3 ORC4 ORC5 PRMT1 PRMT6 RAG1 RPS6KA5 SAP30 SET SETD8 SETDB1 SIAH1 SMARCA5 TAF1A TP53BP1 UBE2I UCHL5 USP16 VHL WDR5	8 interactors: CBFB HIST1H2BC HIST2H2AC HIST2H3C HIST4H4 PRMT5 RUNX1 WDR77
Entrez ID		121504	55352
HPRD ID		13662	13675
Ensembl ID		ENSG00000197837	ENSG00000172301
Uniprot IDs		B2R4R0 P62805	H9KV77 Q9NQ92
PDB IDs		2BQZ 2CV5 2KWN 2KWO 2LVM 2QQS 2RNY 2RS9 3A6N 3AFA 3AN2 3AV1 3AV2 3AYW 3AZE 3AZF 3AZG 3AZH 3AZI 3AZJ 3AZK 3AZL 3AZM 3AZN 3CFS 3CFV 3F9W 3F9X 3F9Y 3F9Z 3NQJ 3NQU 3O36 3QZS 3QZT 3QZV 3R45 3UVW 3UVX 3UVY 3UW9 3W96 3W97 3W98 3W99 4GQB 4H9N 4H9O 4H9P 4H9Q 4H9R 4H9S 4HGA
Enriched GO Terms of Interacting Partners?		Chromatin Organization Chromatin Modification Chromosome Organization Histone Modification Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Peptidyl-lysine Modification Regulation Of RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Organelle Organization Macromolecule Biosynthetic Process Transcription, DNA-templated RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Nitrogen Compound Metabolic Process Biosynthetic Process Negative Regulation Of Biosynthetic Process Peptidyl-amino Acid Modification Gene Expression RNA Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Histone Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Protein Acetylation Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Protein Modification Process Chromatin Assembly Or Disassembly Positive Regulation Of Macromolecule Biosynthetic Process Chromatin Assembly Positive Regulation Of Transcription, DNA-templated Histone H3-K9 Modification Histone Methylation Positive Regulation Of Gene Expression Cell Cycle Nucleosome Assembly DNA Packaging	DNA Methylation On Cytosine Chromatin Silencing At RDNA Definitive Hemopoiesis Cellular Macromolecular Complex Assembly Chromatin Organization Chromatin Silencing Spliceosomal SnRNP Assembly DNA Methylation Chromosome Organization Gene Expression Methylation Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Myeloid Cell Differentiation DNA Modification Gene Silencing Positive Regulation Of Progesterone Secretion Peptidyl-arginine Methylation, To Symmetrical-dimethyl Arginine Regulation Of Transcription, DNA-templated Nucleosome Assembly Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Chromatin Assembly Histone H4-K20 Demethylation Regulation Of Progesterone Secretion Nucleosome Organization Nucleobase-containing Compound Metabolic Process Chromatin Assembly Or Disassembly Heterocycle Metabolic Process Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development Regulation Of Hair Follicle Cell Proliferation Cellular Aromatic Compound Metabolic Process Protein-DNA Complex Assembly Ribonucleoprotein Complex Assembly Regulation Of Gene Expression Regulation Of Myeloid Cell Differentiation Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Megakaryocyte Differentiation DNA Packaging Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression, Epigenetic Cellular Component Assembly Negative Regulation Of Granulocyte Differentiation MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Myeloid Progenitor Cell Differentiation Positive Regulation Of Granulocyte Differentiation Nitrogen Compound Metabolic Process Myeloid Cell Differentiation
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?