TOE1 and IK

Number of citations of the paper that reports this interaction (PubMedID 22365833)
0

Data Source:
BioGRID (two hybrid)

		TOE1	IK
Description		target of EGR1, exonuclease	IK cytokine
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cajal Body Nuclear Body Nuclear Speck	Nuclear Chromosome Spindle Pole Nucleus Nucleoplasm Spliceosomal Complex Chromosome Cytoplasm Cytoskeleton Nuclear Speck U2-type Precatalytic Spliceosome Mitotic Spindle Pole
	Molecular Function	3'-5'-RNA Exonuclease Activity Nucleic Acid Binding Poly(A)-specific Ribonuclease Activity Protein Binding Zinc Ion Binding SnRNA Binding Metal Ion Binding	Protein Binding Identical Protein Binding
	Biological Process	RNA Metabolic Process SnRNA 3'-end Processing	Mitotic Cell Cycle MRNA Splicing, Via Spliceosome MRNA Processing Mitotic Spindle Assembly Checkpoint Signaling RNA Splicing Protein Localization To Kinetochore
Pathways			mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS			Monocyte count ( 32888494) Schizophrenia ( 29483656) Serum immune biomarker levels ( 32066700)
Interacting Genes		27 interacting genes: ABCF3 AGGF1 ANXA1 AP2A1 APLP1 CA12 HNRNPF IK IL7R LSM4 OGT PPP1CA PRCC RAB40C RBM39 RBM8A RPS3A SF3B2 SF3B3 SH3GL3 SQSTM1 SRSF6 SUMO1 U2AF1 UNC13B WDR77 WDR83	28 interacting genes: APP CEBPA CEP70 CHD3 CTNNBL1 DDX6 EGLN3 FANCC FRA10AC1 FXR1 GRB2 KAT5 KDM1A MBD3 MFAP1 NUP62 OGT PFN2 QARS1 RACK1 RBM10 SUPT5H THOC1 TOE1 TRIM55 TRIM63 TTC14 ZCCHC10
Entrez ID		114034	3550
HPRD ID		18212	02771
Ensembl ID		ENSG00000132773	ENSG00000113141
Uniprot IDs		B4DP23 Q96GM8	Q13123 Q95HA6 Q9UK43
PDB IDs		2FC6	5O9Z 6Q8I 8QO9 8QZS
Enriched GO Terms of Interacting Partners?		MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Splicing Spliceosomal Complex MRNA Processing MRNA Metabolic Process Catalytic Step 2 Spliceosome RNA Metabolic Process Nucleoplasm Nuclear Speck Regulation Of RNA Splicing RNA Processing Nucleic Acid Metabolic Process Macromolecule Metabolic Process U2-type Precatalytic Spliceosome Nucleobase-containing Compound Metabolic Process Protein-RNA Complex Assembly Nucleic Acid Binding Regulation Of MRNA Splicing, Via Spliceosome RS Domain Binding Regulation Of MRNA Processing Glutamatergic Synapse Cadherin Binding Involved In Cell-cell Adhesion RNA Binding Transition Metal Ion Binding U2-type Prespliceosome Assembly U12-type Spliceosomal Complex U2 SnRNP Membraneless Organelle Assembly U2-type Spliceosomal Complex Regulation Of Programmed Cell Death Alpha-2B Adrenergic Receptor Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of Synaptic Vesicle Priming Oocyte Axis Specification	Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus PTB Domain Binding Negative Regulation Of RNA Metabolic Process Chromatin Binding Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process Nucleoplasm Negative Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Apoptotic Process Regulation Of Glycolytic Process Programmed Cell Death Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Cell Death Regulation Of Programmed Cell Death RNA Binding Membraneless Organelle Assembly Cellular Response To Glucose Stimulus Regulation Of Carbohydrate Catabolic Process Negative Regulation Of Long-term Synaptic Potentiation Protein-containing Complex Nucleic Acid Metabolic Process Positive Regulation Of Proteolysis Regulation Of ATP Metabolic Process Positive Regulation Of Catabolic Process Negative Regulation Of Gene Expression Regulation Of Purine Nucleotide Metabolic Process Regulation Of Apoptotic Process Carbohydrate Homeostasis Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Glucose Homeostasis Regulation Of Stem Cell Differentiation NuRD Complex Negative Regulation Of Translation Nucleic Acid Binding MRNA Splicing, Via Spliceosome RNA Splicing Cellular Response To Carbohydrate Stimulus Positive Regulation Of RNA Metabolic Process Post-transcriptional Regulation Of Gene Expression RNA Splicing, Via Transesterification Reactions Positive Regulation Of Metabolic Process Translation Regulator Activity Intracellular Glucose Homeostasis
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