CCR5 and PTK2B

Number of citations of the paper that reports this interaction (PMID 9446638)
9

Data Source:
HPRD (in vivo)

		CCR5	PTK2B
Gene Name		chemokine (C-C motif) receptor 5 (gene/pseudogene)	protein tyrosine kinase 2 beta
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Endosome Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Focal Adhesion Cell Cortex Postsynaptic Density N-methyl-D-aspartate Selective Glutamate Receptor Complex Lamellipodium Axon Dendrite Growth Cone Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Neuronal Cell Body Cell Body Membrane Raft Perinuclear Region Of Cytoplasm Apical Dendrite
	Molecular Function	Actin Binding Phosphatidylinositol Phospholipase C Activity Chemokine Receptor Activity Protein Binding Coreceptor Activity C-C Chemokine Receptor Activity C-C Chemokine Binding Chemokine (C-C Motif) Ligand 5 Binding	Calmodulin-dependent Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signal Transducer Activity N-methyl-D-aspartate Selective Glutamate Receptor Activity Receptor Binding Protein Binding ATP Binding Protein Complex Binding 3-phosphoinositide-dependent Protein Kinase Binding
	Biological Process	MAPK Cascade Dendritic Cell Chemotaxis Calcium Ion Transport Chemotaxis Inflammatory Response Immune Response Cellular Defense Response Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Viral Process Calcium-mediated Signaling Signaling Entry Into Host Cell Chemokine-mediated Signaling Pathway Response To Cholesterol Cellular Response To Lipopolysaccharide	MAPK Cascade Angiogenesis Oocyte Maturation Response To Hypoxia Positive Regulation Of Cell-matrix Adhesion Sprouting Angiogenesis Marginal Zone B Cell Differentiation Protein Complex Assembly Protein Phosphorylation Apoptotic Process Response To Stress Cellular Defense Response Response To Osmotic Stress Signal Transduction Cell Surface Receptor Signaling Pathway Signal Complex Assembly Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Integrin-mediated Signaling Pathway Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Regulation Of Cell Shape Response To Mechanical Stimulus Response To Hormone Response To Glucose Response To Lithium Ion Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Muscle Cell Apoptotic Process Regulation Of CGMP-mediated Signaling Regulation Of Macrophage Chemotaxis Positive Regulation Of Neuron Projection Development Glial Cell Proliferation Peptidyl-tyrosine Phosphorylation Regulation Of Cell Adhesion Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Negative Regulation Of Bone Mineralization Regulation Of CGMP Biosynthetic Process Positive Regulation Of Actin Filament Polymerization Neuron Projection Development Activation Of Rac GTPase Activity Regulation Of Inositol Trisphosphate Biosynthetic Process Tumor Necrosis Factor-mediated Signaling Pathway Ionotropic Glutamate Receptor Signaling Pathway Response To Immobilization Stress Peptidyl-tyrosine Autophosphorylation Response To Cocaine Response To Drug Response To Hydrogen Peroxide Activation Of Janus Kinase Activity Negative Regulation Of Apoptotic Process Stress Fiber Assembly Negative Regulation Of Potassium Ion Transport Positive Regulation Of JUN Kinase Activity Negative Regulation Of Neuron Apoptotic Process Blood Vessel Endothelial Cell Migration Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Regulation Of Nitric Oxide Biosynthetic Process Bone Resorption Response To Ethanol Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Translation Positive Regulation Of Angiogenesis Positive Regulation Of Protein Kinase Activity Positive Regulation Of JNK Cascade Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Focal Adhesion Assembly Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Calcium-mediated Signaling Positive Regulation Of Nitric-oxide Synthase Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Response To CAMP Response To Calcium Ion Positive Regulation Of Synaptic Transmission, Glutamatergic Long-term Synaptic Potentiation Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Retinoic Acid Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Establishment Of Cell Polarity Regulation Of Actin Cytoskeleton Reorganization Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Excitatory Postsynaptic Membrane Potential Positive Regulation Of B Cell Chemotaxis
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR HIV Infection Class A/1 (Rhodopsin-like receptors) GPCR ligand binding Metabolic disorders of biological oxidation enzymes Early Phase of HIV Life Cycle GPCR downstream signaling HIV Life Cycle Peptide ligand-binding receptors Chemokine receptors bind chemokines G alpha (i) signalling events Binding and entry of HIV virion	Signaling by Interleukins Signaling by VEGF Cytokine Signaling in Immune system Interleukin-2 signaling Signal regulatory protein (SIRP) family interactions VEGFA-VEGFR2 Pathway
Drugs		Maraviroc	Leflunomide Genistein 4-{[4-{[(1R,2R)-2-(dimethylamino)cyclopentyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-N-methylbenzenesulfonamide
Diseases
GWAS		Celiac disease ( 20190752)	Dental caries ( 23259602)
Protein-Protein Interactions		41 interactors: ADRBK1 ADRBK2 AFP ARL6IP5 ARRB1 CCL11 CCL13 CCL14 CCL16 CCL2 CCL3 CCL3L1 CCL3L3 CCL4 CCL5 CCL7 CCL8 CD4 CST9L CTBP2 CXCR4 DNM2 ETV5 GNAI1 GNAI2 GNAI3 GNAO1 GNAQ IL24 JAK1 JAK2 LCK ORM1 PRAF2 PSMA5 PTK2 PTK2B STAT1 STAT3 STAT5A TXK	70 interactors: ARHGAP21 ARHGAP5 ASAP1 ASAP2 BCAR1 CBL CCR5 CRK DCC DLG3 DLG4 DLGAP3 EFS EGFR ERBB2 ERBB3 EWSR1 FGFR2 FGFR3 FLT1 FYN GNA13 GRB2 GRIN2A GSN IL7R ITGB2 ITGB3 JAK1 JAK2 JAK3 KCNA2 LCK LPXN LYN MAP3K4 MAPT MATK MCAM MYH2 NEDD9 NPHP1 PDCD6IP PDPK1 PIK3R1 PITPNM1 PITPNM2 PITPNM3 PRKCD PTK2 PTPN11 PTPN12 PTPN6 PXN RASA1 RB1CC1 SH2D3C SHC1 SKAP2 SLC2A1 SNCA SORBS2 SRC STAP1 STAT3 SYK TGFB1I1 TLN1 VAV1 ZAP70
Entrez ID		1234	2185
HPRD ID		03223	03131
Ensembl ID		ENSG00000160791	ENSG00000120899
Uniprot IDs		A0A502 P51681 Q38L21	Q14289
PDB IDs		1ND8 1NE0 1OPN 1OPT 1OPW 2L87 2RLL 2RRS 4MBS	2FO6 2LK4 3CC6 3ET7 3FZO 3FZP 3FZR 3FZS 3FZT 3GM1 3GM2 3GM3 3H3C 3U3C 3U3F 4EKU 4H1J 4H1M
Enriched GO Terms of Interacting Partners?		Response To Stress Cell Chemotaxis Defense Response Immune Response Immune System Process Cellular Response To Stimulus Inflammatory Response Cell Migration Cell Motility Response To Stimulus Response To External Stimulus Signaling Locomotion Cell Communication Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Positive Regulation Of Catalytic Activity Regulation Of Catalytic Activity Signal Transduction Regulation Of Cell Proliferation Chemotaxis Movement Of Cell Or Subcellular Component Positive Regulation Of Metabolic Process Eosinophil Chemotaxis Eosinophil Migration Cellular Metal Ion Homeostasis Cell Activation Cellular Cation Homeostasis Positive Regulation Of Signal Transduction Regulation Of Lymphocyte Migration Cellular Ion Homeostasis Metal Ion Homeostasis Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Natural Killer Cell Chemotaxis Cellular Chemical Homeostasis Regulation Of Signal Transduction Regulation Of Signaling Chemical Homeostasis Response To Cytokine Ion Homeostasis Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Migration Regulation Of Cell Motility Positive Regulation Of Intracellular Signal Transduction Growth Hormone Receptor Signaling Pathway Leukocyte Chemotaxis Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Granulocyte Chemotaxis Cellular Response To Growth Hormone Stimulus	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cell Communication Signaling Movement Of Cell Or Subcellular Component Epidermal Growth Factor Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation ERBB Signaling Pathway Response To Wounding Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Signaling Regulation Of Signal Transduction Locomotion Wound Healing Immune Response-regulating Signaling Pathway Innate Immune Response Fc Receptor Signaling Pathway Positive Regulation Of Signal Transduction Platelet Activation Regulation Of Immune Response Cell Migration Cellular Response To Stimulus Neurotrophin TRK Receptor Signaling Pathway Cell Activation Cellular Response To Fibroblast Growth Factor Stimulus Neurotrophin Signaling Pathway Response To Fibroblast Growth Factor Cell Motility Protein Autophosphorylation Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Blood Coagulation Cellular Response To Peptide Hormone Stimulus Hemostasis Cell Surface Receptor Signaling Pathway Response To Growth Factor Cellular Response To Peptide Immune Response Regulation Of Immune System Process Cellular Response To Organonitrogen Compound Defense Response Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Catalytic Activity Response To Stress Regulation Of Intracellular Signal Transduction Regulation Of Cell Adhesion Vascular Endothelial Growth Factor Receptor Signaling Pathway Leukocyte Migration Response To Organonitrogen Compound
Tagcloud ?		7b11 aminoxypentane augmented broadening ccr1 ccr2 ccr3 chemokine chemokines chemotactic cxc cxcr1 eotaxin hcc2 leukocytes mcp migrate migrated mip monocyte orienting pmn polymorphonuclear prototypic rantes reorients speculate th1 th2	advent broadly cass4 debilitating driving emphasized fact genotypic gwas inform interacting intriguingly limit load microtubule nedd9 occurrences oncogenesis options paralogous partners pathophysiology phenotypic reciprocally reflects scaffolding snps stabilization viable
Tagcloud (Difference) ?		7b11 aminoxypentane augmented broadening ccr1 ccr2 ccr3 chemokine chemokines chemotactic cxc cxcr1 eotaxin hcc2 leukocytes mcp migrate migrated mip monocyte orienting pmn polymorphonuclear prototypic rantes reorients speculate th1 th2	advent broadly cass4 debilitating driving emphasized fact genotypic gwas inform interacting intriguingly limit load microtubule nedd9 occurrences oncogenesis options paralogous partners pathophysiology phenotypic reciprocally reflects scaffolding snps stabilization viable
Tagcloud (Intersection) ?