CCR5 and PRAF2

Number of citations of the paper that reports this interaction (PubMedID 15757671)
0

Data Source:
HPRD (two hybrid, in vivo)

		CCR5	PRAF2
Description		C-C motif chemokine receptor 5	PRA1 domain family member 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane	Endosome Endosome Membrane Membrane Presynapse Postsynapse Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	Virus Receptor Activity Actin Binding Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding Coreceptor Activity C-C Chemokine Receptor Activity C-C Chemokine Binding Identical Protein Binding Chemokine (C-C Motif) Ligand 5 Binding	Protein Binding
	Biological Process	MAPK Cascade Dendritic Cell Chemotaxis Calcium Ion Transport Apoptotic Process Chemotaxis Defense Response Inflammatory Response Immune Response Cellular Defense Response Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Calcium-mediated Signaling Signaling Symbiont Entry Into Host Cell Cell Chemotaxis Chemokine-mediated Signaling Pathway Response To Cholesterol Cellular Response To Lipopolysaccharide Cellular Response To Cytokine Stimulus Negative Regulation Of Macrophage Apoptotic Process	Protein Transport L-glutamate Transmembrane Transport
Pathways		Binding and entry of HIV virion Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling
Drugs		Maraviroc AMD-070 CCR5 mAb Leronlimab Aplaviroc Vicriviroc Ibalizumab INCB-9471
Diseases
GWAS		Blood protein levels in cardiovascular risk ( 28369058) Celiac disease ( 20190752) Cerebrospinal fluid levels of Alzheimer's disease-related proteins ( 25340798) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 26192919) Type 1 diabetes ( 25751624) Ulcerative colitis ( 26192919 28067908)
Interacting Genes		43 interacting genes: AFP ARL6IP5 ARRB1 CCL11 CCL13 CCL14 CCL16 CCL2 CCL3 CCL3L1 CCL3L3 CCL4 CCL5 CCL7 CCL8 CD4 CST9L CTBP2 CXCR4 DNM2 EMP1 ETV5 GNAI1 GNAI2 GNAI3 GNAO1 GNAQ GRK2 GRK3 IL24 JAK1 JAK2 LCK ORM1 PRAF2 PSMA5 PTK2 PTK2B SLC20A2 STAT1 STAT3 STAT5A TXK	27 interacting genes: ABHD16A ADGRD1 AGR3 AQP6 ARL6IP5 CCR5 CD79A CFTR CIAO2A CLEC10A EBAG9 GJA5 GJA8 GPR152 HIBADH HSD17B11 MCEMP1 MIEF1 NDRG4 REEP4 RETREG3 RNF5 SLC10A6 TLCD4 TMEM14B TMX2 ZDHHC15
Entrez ID		1234	11230
HPRD ID		03223	06596
Ensembl ID		ENSG00000160791	ENSG00000243279
Uniprot IDs		P51681 Q38L21	O60831
PDB IDs		2L87 2MZX 2RLL 2RRS 4MBS 5UIW 5YD3 5YD4 5YD5 5YY4 6FGP 6MEO 6MET 7F1Q 7F1R 7F1S 7NJZ 7NW3 7O7F 8AS2 8AS3
Enriched GO Terms of Interacting Partners?		Chemokine-mediated Signaling Pathway CCR Chemokine Receptor Binding Cytokine-mediated Signaling Pathway Chemokine Activity G Protein-coupled Receptor Signaling Pathway Eosinophil Chemotaxis Eosinophil Migration Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Antimicrobial Humoral Response Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cell Chemotaxis Cytokine Activity CCR5 Chemokine Receptor Binding Immune System Process Immune Response Cell Surface Receptor Signaling Pathway Regulation Of Cell Migration Humoral Immune Response Regulation Of Cell Motility Signal Transduction Regulation Of Locomotion Granulocyte Chemotaxis Leukocyte Migration Chemotaxis Granulocyte Migration Defense Response Cell Migration Leukocyte Chemotaxis Inflammatory Response Locomotion Response To Other Organism Response To External Biotic Stimulus Cell Motility Regulation Of Lymphocyte Chemotaxis Myeloid Leukocyte Migration Defense Response To Symbiont Positive Regulation Of Natural Killer Cell Chemotaxis Defense Response To Other Organism Guanyl Nucleotide Binding CCR1 Chemokine Receptor Binding G Protein-coupled Receptor Binding Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Lymphocyte Chemotaxis Cell Surface Receptor Signaling Pathway Via STAT Non-membrane Spanning Protein Tyrosine Kinase Activity G-protein Beta/gamma-subunit Complex Binding Protein Kinase Activity Interleukin-9-mediated Signaling Pathway	Membrane Endoplasmic Reticulum Nitrate Transmembrane Transporter Activity Protein Binding Fluid Transport Transmembrane Transport Water Transport Endoplasmic Reticulum Membrane Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Gap Junction Channel Activity Involved In Purkinje Myocyte-ventricular Cardiac Muscle Cell Electrical Coupling Mitral Valve Development Septum Primum Development Gap Junction Channel Activity Involved In Atrial Cardiac Muscle Cell-AV Node Cell Electrical Coupling Gap Junction Atrial Ventricular Junction Remodeling Gap Junction Channel Activity Involved In Bundle Of His Cell-Purkinje Myocyte Electrical Coupling Embryonic Heart Tube Development Gap Junction Channel Activity Positive Regulation Of Cell Communication By Chemical Coupling Atrial Cardiac Muscle Cell To AV Node Cell Communication By Electrical Coupling Vasomotion Purkinje Myocyte To Ventricular Cardiac Muscle Cell Communication By Electrical Coupling Regulation Of Purkinje Myocyte Action Potential Connexin Complex 3-hydroxyisobutyrate Dehydrogenase Activity Endoplasmic Reticulum Tubular Network Endoplasmic Reticulum Tubular Network Organization Sodium-dependent Organic Anion Transmembrane Transporter Activity Sodium-dependent Organic Anion Transport Positive Regulation Of Neuron Projection Development
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