CCR5 and CST9L

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		CCR5	CST9L
Gene Name		chemokine (C-C motif) receptor 5 (gene/pseudogene)	cystatin 9-like
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Endosome Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface	Extracellular Region
	Molecular Function	Actin Binding Phosphatidylinositol Phospholipase C Activity Chemokine Receptor Activity Protein Binding Coreceptor Activity C-C Chemokine Receptor Activity C-C Chemokine Binding Chemokine (C-C Motif) Ligand 5 Binding	Cysteine-type Endopeptidase Inhibitor Activity
	Biological Process	MAPK Cascade Dendritic Cell Chemotaxis Calcium Ion Transport Chemotaxis Inflammatory Response Immune Response Cellular Defense Response Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Viral Process Calcium-mediated Signaling Signaling Entry Into Host Cell Chemokine-mediated Signaling Pathway Response To Cholesterol Cellular Response To Lipopolysaccharide	Negative Regulation Of Endopeptidase Activity
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR HIV Infection Class A/1 (Rhodopsin-like receptors) GPCR ligand binding Metabolic disorders of biological oxidation enzymes Early Phase of HIV Life Cycle GPCR downstream signaling HIV Life Cycle Peptide ligand-binding receptors Chemokine receptors bind chemokines G alpha (i) signalling events Binding and entry of HIV virion
Drugs		Maraviroc
Diseases
GWAS		Celiac disease ( 20190752)	Cystatin C ( 17903292)
Protein-Protein Interactions		41 interactors: ADRBK1 ADRBK2 AFP ARL6IP5 ARRB1 CCL11 CCL13 CCL14 CCL16 CCL2 CCL3 CCL3L1 CCL3L3 CCL4 CCL5 CCL7 CCL8 CD4 CST9L CTBP2 CXCR4 DNM2 ETV5 GNAI1 GNAI2 GNAI3 GNAO1 GNAQ IL24 JAK1 JAK2 LCK ORM1 PRAF2 PSMA5 PTK2 PTK2B STAT1 STAT3 STAT5A TXK	6 interactors: CCR5 KRTAP10-3 KRTAP10-9 NOTCH2NL SLC22A2 TAB2
Entrez ID		1234	128821
HPRD ID		03223	16769
Ensembl ID		ENSG00000160791	ENSG00000101435
Uniprot IDs		A0A502 P51681 Q38L21	Q9H4G1
PDB IDs		1ND8 1NE0 1OPN 1OPT 1OPW 2L87 2RLL 2RRS 4MBS
Enriched GO Terms of Interacting Partners?		Response To Stress Cell Chemotaxis Defense Response Immune Response Immune System Process Cellular Response To Stimulus Inflammatory Response Cell Migration Cell Motility Response To Stimulus Response To External Stimulus Signaling Locomotion Cell Communication Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Positive Regulation Of Catalytic Activity Regulation Of Catalytic Activity Signal Transduction Regulation Of Cell Proliferation Chemotaxis Movement Of Cell Or Subcellular Component Positive Regulation Of Metabolic Process Eosinophil Chemotaxis Eosinophil Migration Cellular Metal Ion Homeostasis Cell Activation Cellular Cation Homeostasis Positive Regulation Of Signal Transduction Regulation Of Lymphocyte Migration Cellular Ion Homeostasis Metal Ion Homeostasis Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Natural Killer Cell Chemotaxis Cellular Chemical Homeostasis Regulation Of Signal Transduction Regulation Of Signaling Chemical Homeostasis Response To Cytokine Ion Homeostasis Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Migration Regulation Of Cell Motility Positive Regulation Of Intracellular Signal Transduction Growth Hormone Receptor Signaling Pathway Leukocyte Chemotaxis Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Granulocyte Chemotaxis Cellular Response To Growth Hormone Stimulus	MAPK Cascade Signal Transduction By Phosphorylation Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Choline Transport Sarcoplasmic Reticulum Calcium Ion Transport Dendritic Cell Chemotaxis Neurotransmitter Biosynthetic Process Histamine Transport Quaternary Ammonium Group Transport Signaling Cell Communication Response To Cholesterol Dendritic Cell Migration Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Neurotransmitter Metabolic Process Drug Transmembrane Transport Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Sequestering Of Calcium Ion Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Ammonium Transmembrane Transport Organic Cation Transport Drug Transport Entry Into Host Cell Calcium Ion Transport Into Cytosol Cytosolic Calcium Ion Transport Cell Surface Receptor Signaling Pathway Cell-cell Signaling Toll-like Receptor 5 Signaling Pathway Cellular Defense Response Toll-like Receptor 10 Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Chemokine-mediated Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway
Tagcloud ?		7b11 aminoxypentane augmented broadening ccr1 ccr2 ccr3 chemokine chemokines chemotactic cxc cxcr1 eotaxin hcc2 leukocytes mcp migrate migrated mip monocyte orienting pmn polymorphonuclear prototypic rantes reorients speculate th1 th2
Tagcloud (Difference) ?		7b11 aminoxypentane augmented broadening ccr1 ccr2 ccr3 chemokine chemokines chemotactic cxc cxcr1 eotaxin hcc2 leukocytes mcp migrate migrated mip monocyte orienting pmn polymorphonuclear prototypic rantes reorients speculate th1 th2
Tagcloud (Intersection) ?