CCR5 and CCL4

Number of citations of the paper that reports this interaction (PubMedID 12427015)
0

Data Source:
HPRD (in vitro, in vivo)

		CCR5	CCL4
Description		C-C motif chemokine receptor 5	C-C motif chemokine ligand 4
Image
GO Annotations	Cellular Component	Cytoplasm Endosome Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane	Extracellular Region Extracellular Space
	Molecular Function	Virus Receptor Activity Actin Binding Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding Coreceptor Activity C-C Chemokine Receptor Activity C-C Chemokine Binding Identical Protein Binding Chemokine (C-C Motif) Ligand 5 Binding	Cytokine Activity Protein Binding Chemokine Activity CCR1 Chemokine Receptor Binding CCR5 Chemokine Receptor Binding Identical Protein Binding CCR Chemokine Receptor Binding
	Biological Process	MAPK Cascade Dendritic Cell Chemotaxis Calcium Ion Transport Apoptotic Process Chemotaxis Defense Response Inflammatory Response Immune Response Cellular Defense Response Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Calcium-mediated Signaling Signaling Symbiont Entry Into Host Cell Cell Chemotaxis Chemokine-mediated Signaling Pathway Response To Cholesterol Cellular Response To Lipopolysaccharide Cellular Response To Cytokine Stimulus Negative Regulation Of Macrophage Apoptotic Process	Chemotaxis Inflammatory Response Immune Response Cell Adhesion Establishment Or Maintenance Of Cell Polarity Signal Transduction Cell-cell Signaling Response To Virus Response To Toxic Substance Positive Regulation Of Cell Migration Host-mediated Suppression Of Viral Transcription Eosinophil Chemotaxis Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of Calcium Ion Transport Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Positive Regulation Of Natural Killer Cell Chemotaxis
Pathways		Binding and entry of HIV virion Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling	Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling
Drugs		Maraviroc AMD-070 CCR5 mAb Leronlimab Aplaviroc Vicriviroc Ibalizumab INCB-9471
Diseases
GWAS		Blood protein levels in cardiovascular risk ( 28369058) Celiac disease ( 20190752) Cerebrospinal fluid levels of Alzheimer's disease-related proteins ( 25340798) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 26192919) Type 1 diabetes ( 25751624) Ulcerative colitis ( 26192919 28067908)	Blood protein levels in cardiovascular risk ( 28369058) Body mass index ( 26426971) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		43 interacting genes: AFP ARL6IP5 ARRB1 CCL11 CCL13 CCL14 CCL16 CCL2 CCL3 CCL3L1 CCL3L3 CCL4 CCL5 CCL7 CCL8 CD4 CST9L CTBP2 CXCR4 DNM2 EMP1 ETV5 GNAI1 GNAI2 GNAI3 GNAO1 GNAQ GRK2 GRK3 IL24 JAK1 JAK2 LCK ORM1 PRAF2 PSMA5 PTK2 PTK2B SLC20A2 STAT1 STAT3 STAT5A TXK	26 interacting genes: ACKR2 ARL13B CCL3 CCR1 CCR3 CCR5 CCR8 CNR2 CXCL8 GJA8 GPR152 GPRC5D MARCHF2 MRM1 SLC10A6 SLC18A1 SLC30A2 SLC30A8 SLC7A1 TAS2R5 TIMMDC1 TMEM14B TMEM179B TMEM31 TMEM86B UNC93A
Entrez ID		1234	6351
HPRD ID		03223	01657
Ensembl ID		ENSG00000160791	ENSG00000275302
Uniprot IDs		P51681 Q38L21	P13236
PDB IDs		2L87 2MZX 2RLL 2RRS 4MBS 5UIW 5YD3 5YD4 5YD5 5YY4 6FGP 6MEO 6MET 7F1Q 7F1R 7F1S 7NJZ 7NW3 7O7F 8AS2 8AS3	1HUM 1HUN 1JE4 2FFK 2FIN 2X6L 3TN2 4RAL
Enriched GO Terms of Interacting Partners?		Chemokine-mediated Signaling Pathway CCR Chemokine Receptor Binding Cytokine-mediated Signaling Pathway Chemokine Activity G Protein-coupled Receptor Signaling Pathway Eosinophil Chemotaxis Eosinophil Migration Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Antimicrobial Humoral Response Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cell Chemotaxis Cytokine Activity CCR5 Chemokine Receptor Binding Immune System Process Immune Response Cell Surface Receptor Signaling Pathway Regulation Of Cell Migration Humoral Immune Response Regulation Of Cell Motility Signal Transduction Regulation Of Locomotion Granulocyte Chemotaxis Leukocyte Migration Chemotaxis Granulocyte Migration Defense Response Cell Migration Leukocyte Chemotaxis Inflammatory Response Locomotion Response To Other Organism Response To External Biotic Stimulus Cell Motility Regulation Of Lymphocyte Chemotaxis Myeloid Leukocyte Migration Defense Response To Symbiont Positive Regulation Of Natural Killer Cell Chemotaxis Defense Response To Other Organism Guanyl Nucleotide Binding CCR1 Chemokine Receptor Binding G Protein-coupled Receptor Binding Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Lymphocyte Chemotaxis Cell Surface Receptor Signaling Pathway Via STAT Non-membrane Spanning Protein Tyrosine Kinase Activity G-protein Beta/gamma-subunit Complex Binding Protein Kinase Activity Interleukin-9-mediated Signaling Pathway	Chemokine Receptor Activity C-C Chemokine Binding C-C Chemokine Receptor Activity Cell Chemotaxis Chemotaxis Chemokine-mediated Signaling Pathway Locomotion G Protein-coupled Receptor Activity Calcium-mediated Signaling G Protein-coupled Receptor Signaling Pathway Membrane Plasma Membrane Chemokine (C-C Motif) Ligand 5 Binding Leukocyte Chemotaxis Positive Regulation Of Cytosolic Calcium Ion Concentration Cell Migration Immune Response Inflammatory Response Response To Cytokine Response To Peptide Zinc:proton Antiporter Activity Cell Motility Leukocyte Migration Cytokine-mediated Signaling Pathway Intracellular Signaling Cassette Cellular Response To Cytokine Stimulus Transport Vesicle Membrane Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Zinc Ion Import Into Organelle Release Of Sequestered Calcium Ion Into Cytosol By Endoplasmic Reticulum Monoatomic Cation Transport Defense Response External Side Of Plasma Membrane Sarcoplasmic Reticulum Calcium Ion Transport Dendritic Cell Chemotaxis Metal Ion Transport Transmembrane Transport Response To Interleukin-1 Monoatomic Cation Transmembrane Transporter Activity Import Into Cell Negative Regulation Of Bone Mineralization Positive Regulation Of Leukocyte Chemotaxis Immune System Process Monoatomic Ion Transport Positive Regulation Of Neuroinflammatory Response Secretory Granule Membrane Monocyte Chemotaxis Zinc Ion Transmembrane Transporter Activity Dendritic Cell Migration Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity
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