CCR5 and CCL4

Number of citations of the paper that reports this interaction (PMID 8663314)
91

Data Source:
HPRD (in vivo, in vitro)

		CCR5	CCL4
Gene Name		chemokine (C-C motif) receptor 5 (gene/pseudogene)	chemokine (C-C motif) ligand 4
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Endosome Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface	Extracellular Region Extracellular Space
	Molecular Function	Actin Binding Phosphatidylinositol Phospholipase C Activity Chemokine Receptor Activity Protein Binding Coreceptor Activity C-C Chemokine Receptor Activity C-C Chemokine Binding Chemokine (C-C Motif) Ligand 5 Binding	Cytokine Activity Protein Binding Chemokine Activity CCR1 Chemokine Receptor Binding CCR5 Chemokine Receptor Binding Identical Protein Binding
	Biological Process	MAPK Cascade Dendritic Cell Chemotaxis Calcium Ion Transport Chemotaxis Inflammatory Response Immune Response Cellular Defense Response Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Viral Process Calcium-mediated Signaling Signaling Entry Into Host Cell Chemokine-mediated Signaling Pathway Response To Cholesterol Cellular Response To Lipopolysaccharide	Movement Of Cell Or Subcellular Component Inflammatory Response Immune Response Cell Adhesion Establishment Or Maintenance Of Cell Polarity Signal Transduction Cell-cell Signaling Response To Virus Response To Toxic Substance Negative Regulation By Host Of Viral Transcription Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of Calcium Ion Transport Cell Chemotaxis Positive Regulation Of Natural Killer Cell Chemotaxis
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR HIV Infection Class A/1 (Rhodopsin-like receptors) GPCR ligand binding Metabolic disorders of biological oxidation enzymes Early Phase of HIV Life Cycle GPCR downstream signaling HIV Life Cycle Peptide ligand-binding receptors Chemokine receptors bind chemokines G alpha (i) signalling events Binding and entry of HIV virion	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs		Maraviroc
Diseases
GWAS		Celiac disease ( 20190752)
Protein-Protein Interactions		41 interactors: ADRBK1 ADRBK2 AFP ARL6IP5 ARRB1 CCL11 CCL13 CCL14 CCL16 CCL2 CCL3 CCL3L1 CCL3L3 CCL4 CCL5 CCL7 CCL8 CD4 CST9L CTBP2 CXCR4 DNM2 ETV5 GNAI1 GNAI2 GNAI3 GNAO1 GNAQ IL24 JAK1 JAK2 LCK ORM1 PRAF2 PSMA5 PTK2 PTK2B STAT1 STAT3 STAT5A TXK	8 interactors: ACKR2 CCL3 CCR1 CCR3 CCR5 CCR8 CXCL8 SLC30A2
Entrez ID		1234	6351
HPRD ID		03223	01657
Ensembl ID		ENSG00000160791
Uniprot IDs		A0A502 P51681 Q38L21	P13236
PDB IDs		1ND8 1NE0 1OPN 1OPT 1OPW 2L87 2RLL 2RRS 4MBS	1HUM 1HUN 1JE4 2FFK 2FIN 2X6L 3TN2
Enriched GO Terms of Interacting Partners?		Response To Stress Cell Chemotaxis Defense Response Immune Response Immune System Process Cellular Response To Stimulus Inflammatory Response Cell Migration Cell Motility Response To Stimulus Response To External Stimulus Signaling Locomotion Cell Communication Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Positive Regulation Of Catalytic Activity Regulation Of Catalytic Activity Signal Transduction Regulation Of Cell Proliferation Chemotaxis Movement Of Cell Or Subcellular Component Positive Regulation Of Metabolic Process Eosinophil Chemotaxis Eosinophil Migration Cellular Metal Ion Homeostasis Cell Activation Cellular Cation Homeostasis Positive Regulation Of Signal Transduction Regulation Of Lymphocyte Migration Cellular Ion Homeostasis Metal Ion Homeostasis Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Natural Killer Cell Chemotaxis Cellular Chemical Homeostasis Regulation Of Signal Transduction Regulation Of Signaling Chemical Homeostasis Response To Cytokine Ion Homeostasis Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Migration Regulation Of Cell Motility Positive Regulation Of Intracellular Signal Transduction Growth Hormone Receptor Signaling Pathway Leukocyte Chemotaxis Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Granulocyte Chemotaxis Cellular Response To Growth Hormone Stimulus	Chemokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Chemotaxis Response To Cytokine Positive Regulation Of Cytosolic Calcium Ion Concentration Inflammatory Response Cytokine-mediated Signaling Pathway Cytosolic Calcium Ion Homeostasis Locomotion Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Leukocyte Chemotaxis Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Response To External Stimulus Cellular Ion Homeostasis Cellular Response To Organic Substance Cell Chemotaxis Metal Ion Homeostasis Cellular Chemical Homeostasis G-protein Coupled Receptor Signaling Pathway Ion Homeostasis Leukocyte Migration Immune Response Defense Response Cellular Homeostasis Response To Organic Substance Positive Regulation Of Leukocyte Chemotaxis Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Positive Regulation Of Leukocyte Migration Chemical Homeostasis Calcium-mediated Signaling Cell Surface Receptor Signaling Pathway Sarcoplasmic Reticulum Calcium Ion Transport Positive Regulation Of Chemotaxis Regulation Of Leukocyte Migration Positive Regulation Of Behavior Dendritic Cell Chemotaxis Regulation Of Chemotaxis Second-messenger-mediated Signaling Immune System Process Cellular Response To Lipopolysaccharide Cellular Response To Molecule Of Bacterial Origin Neutrophil Activation Regulation Of Ion Homeostasis Negative Regulation Of Bone Mineralization Negative Regulation Of Biomineral Tissue Development Response To Cholesterol Regulation Of Behavior Dendritic Cell Migration
Tagcloud ?		7b11 aminoxypentane augmented broadening ccr1 ccr2 ccr3 chemokine chemokines chemotactic cxc cxcr1 eotaxin hcc2 leukocytes mcp migrate migrated mip monocyte orienting pmn polymorphonuclear prototypic rantes reorients speculate th1 th2	acetyltransferase boxes cat chloramphenicol coinciding construct constructs fibrogenesis fibrogenic fibrotic hepatic igfiir inducer latent livers m6p mannose mutagenized p75 participating participation quiescent reporter repressor residing stellate stimulant tetrachloride transcript
Tagcloud (Difference) ?		7b11 aminoxypentane augmented broadening ccr1 ccr2 ccr3 chemokine chemokines chemotactic cxc cxcr1 eotaxin hcc2 leukocytes mcp migrate migrated mip monocyte orienting pmn polymorphonuclear prototypic rantes reorients speculate th1 th2	acetyltransferase boxes cat chloramphenicol coinciding construct constructs fibrogenesis fibrogenic fibrotic hepatic igfiir inducer latent livers m6p mannose mutagenized p75 participating participation quiescent reporter repressor residing stellate stimulant tetrachloride transcript
Tagcloud (Intersection) ?