CCR5 and AFP

Number of citations of the paper that reports this interaction (PubMedID 12176010)
0

Data Source:
HPRD (in vivo, in vitro)

		CCR5	AFP
Description		C-C motif chemokine receptor 5	alpha fetoprotein
Image
GO Annotations	Cellular Component	Cytoplasm Endosome Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen
	Molecular Function	Virus Receptor Activity Actin Binding Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding Coreceptor Activity C-C Chemokine Receptor Activity C-C Chemokine Binding Identical Protein Binding Chemokine (C-C Motif) Ligand 5 Binding	Protein Binding Small Molecule Binding Metal Ion Binding
	Biological Process	MAPK Cascade Dendritic Cell Chemotaxis Calcium Ion Transport Apoptotic Process Chemotaxis Defense Response Inflammatory Response Immune Response Cellular Defense Response Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Calcium-mediated Signaling Signaling Symbiont Entry Into Host Cell Cell Chemotaxis Chemokine-mediated Signaling Pathway Response To Cholesterol Cellular Response To Lipopolysaccharide Cellular Response To Cytokine Stimulus Negative Regulation Of Macrophage Apoptotic Process	Ovulation From Ovarian Follicle Apoptotic Process Immune Response Sexual Reproduction Response To Nutrient Levels Progesterone Metabolic Process Homeostasis Of Number Of Cells
Pathways		Binding and entry of HIV virion Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs		Maraviroc AMD-070 CCR5 mAb Leronlimab Aplaviroc Vicriviroc Ibalizumab INCB-9471
Diseases
GWAS		Blood protein levels in cardiovascular risk ( 28369058) Celiac disease ( 20190752) Cerebrospinal fluid levels of Alzheimer's disease-related proteins ( 25340798) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 26192919) Type 1 diabetes ( 25751624) Ulcerative colitis ( 26192919 28067908)	Blood protein levels ( 30072576) Prostate cancer ( 23535732) Tumor biomarkers ( 23300138)
Interacting Genes		43 interacting genes: AFP ARL6IP5 ARRB1 CCL11 CCL13 CCL14 CCL16 CCL2 CCL3 CCL3L1 CCL3L3 CCL4 CCL5 CCL7 CCL8 CD4 CST9L CTBP2 CXCR4 DNM2 EMP1 ETV5 GNAI1 GNAI2 GNAI3 GNAO1 GNAQ GRK2 GRK3 IL24 JAK1 JAK2 LCK ORM1 PRAF2 PSMA5 PTK2 PTK2B SLC20A2 STAT1 STAT3 STAT5A TXK	14 interacting genes: AP4S1 CASP3 CCR5 CREBBP EHD4 GNB1 MED27 PHB2 PIDD1 PSMB7 PTEN SGSM2 SIRT1 XIAP
Entrez ID		1234	174
HPRD ID		03223	00074
Ensembl ID		ENSG00000160791	ENSG00000081051
Uniprot IDs		P51681 Q38L21	P02771
PDB IDs		2L87 2MZX 2RLL 2RRS 4MBS 5UIW 5YD3 5YD4 5YD5 5YY4 6FGP 6MEO 6MET 7F1Q 7F1R 7F1S 7NJZ 7NW3 7O7F 8AS2 8AS3	3MRK 7RE7 7RE8 7YIM 8X1N
Enriched GO Terms of Interacting Partners?		Chemokine-mediated Signaling Pathway CCR Chemokine Receptor Binding Cytokine-mediated Signaling Pathway Chemokine Activity G Protein-coupled Receptor Signaling Pathway Eosinophil Chemotaxis Eosinophil Migration Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Antimicrobial Humoral Response Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cell Chemotaxis Cytokine Activity CCR5 Chemokine Receptor Binding Immune System Process Immune Response Cell Surface Receptor Signaling Pathway Regulation Of Cell Migration Humoral Immune Response Regulation Of Cell Motility Signal Transduction Regulation Of Locomotion Granulocyte Chemotaxis Leukocyte Migration Chemotaxis Granulocyte Migration Defense Response Cell Migration Leukocyte Chemotaxis Inflammatory Response Locomotion Response To Other Organism Response To External Biotic Stimulus Cell Motility Regulation Of Lymphocyte Chemotaxis Myeloid Leukocyte Migration Defense Response To Symbiont Positive Regulation Of Natural Killer Cell Chemotaxis Defense Response To Other Organism Guanyl Nucleotide Binding CCR1 Chemokine Receptor Binding G Protein-coupled Receptor Binding Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Lymphocyte Chemotaxis Cell Surface Receptor Signaling Pathway Via STAT Non-membrane Spanning Protein Tyrosine Kinase Activity G-protein Beta/gamma-subunit Complex Binding Protein Kinase Activity Interleukin-9-mediated Signaling Pathway	Intracellular Signal Transduction Regulation Of Protein Stability Cell Death Apoptotic Process Programmed Cell Death Endopeptidase Activity Rhythmic Process Peptidyl-lysine Acetylation Regulation Of Cellular Response To Heat Cytoplasm Death Receptor Binding Negative Regulation Of Cellular Senescence Execution Phase Of Apoptosis Response To UV DNA Damage Response Regulation Of Myeloid Cell Apoptotic Process Protein Acetylation Innate Immune Response-activating Signaling Pathway Post-translational Protein Modification Intracellular Signaling Cassette Negative Regulation Of Apoptotic Process Positive Regulation Of Defense Response Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Ovulation Cycle Process Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Activation Of Innate Immune Response Regulation Of Programmed Cell Death Protein Metabolic Process Regulation Of Cellular Senescence Negative Regulation Of Synaptic Vesicle Clustering NAD-dependent Protein Decrotonylase Activity Histone H4K12 Deacetylase Activity, Hydrolytic Mechanism Negative Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Maintenance Of Nucleus Location Histone Decrotonylase Activity, NAD-dependent Histone H3K14 Deacetylase Activity, NAD-dependent Negative Regulation Of Cellular Response To Testosterone Stimulus Histone H3K Deacetylase Activity Protein Stabilization Protein Modification Process Positive Regulation Of Protein Linear Polyubiquitination Response To Stress Regulation Of Apoptosis Involved In Tissue Homeostasis Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Canonical NF-kappaB Signal Transduction Response To Hypoxia Phospholipase A2 Activator Activity Chemokine (C-C Motif) Ligand 5 Binding P53 Binding
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