CYLC2 and MLH3

Number of citations of the paper that reports this interaction (PubMedID 24412244)
0

Data Source:
BioGRID (two hybrid)

		CYLC2	MLH3
Description		cylicin 2	mutL homolog 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytoskeleton Perinuclear Theca Cytoskeletal Calyx	Condensed Chromosome Condensed Nuclear Chromosome Synaptonemal Complex Male Germ Cell Nucleus Nucleus Nucleoplasm Chiasma Mismatch Repair Complex
	Molecular Function	Structural Constituent Of Cytoskeleton	Chromatin Binding Satellite DNA Binding Protein Binding ATP Binding ATP Hydrolysis Activity Centromeric DNA Binding Mismatched DNA Binding ATP-dependent DNA Damage Sensor Activity
	Biological Process	Cytoskeleton Organization Spermatogenesis Cell Differentiation	DNA Repair Mismatch Repair DNA Damage Response Synaptonemal Complex Assembly Reciprocal Meiotic Recombination Male Meiotic Nuclear Division Female Meiosis I Intracellular Protein Localization
Pathways			Meiotic recombination
Drugs
Diseases			Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome
GWAS		Chronic rhinosinusitis ( 33393196) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Tourette's syndrome or obsessive-compulsive disorder ( 25158072)	Inflammatory bowel disease ( 23128233) Mood instability ( 29187730) Refractive error ( 32231278)
Interacting Genes		13 interacting genes: AURKA BUB1 CDKN2A EGFR ERBB2 MAP2K4 MCC MLH1 MLH3 MUTYH NRAS SMAD2 STK11	48 interacting genes: AKT1 ALDOB ANP32B AOPEP AR BAAT CCDC180 CDC14B CDK8 CTSV CYLC2 DVL1 EXO1 FANCC FBP1 FBP2 FRAT2 GALNT12 HEMGN HRAS HSD17B3 IGFBP3 LEF1 MAP2K1 MLH1 MSANTD3 MSH4 MSH5 NANS PCNA PPP2CB PPP3R2 RASA1 SEC61B SFRP2 SMAD1 STX17 TBC1D2 TDRD7 TGFB1 TMEFF1 TMOD1 TRIM55 TRIM63 TSTD2 XPA ZDHHC17 ZNF510
Entrez ID		1539	27030
HPRD ID		04945	05094
Ensembl ID		ENSG00000155833	ENSG00000119684
Uniprot IDs		Q14093 Q6PEJ5	Q2M1Z1 Q9UHC1
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Epithelial Cell Proliferation Chiasma Protein Kinase Activity Intracellular Signal Transduction Mismatch Repair ATP Binding Kinase Activity Negative Regulation Of Immature T Cell Proliferation In Thymus Mismatch Repair Complex Negative Regulation Of Immature T Cell Proliferation MutSalpha Complex Binding Nucleotide Binding ERBB2-EGFR Signaling Pathway Negative Regulation Of T Cell Differentiation In Thymus Intracellular Signaling Cassette Mismatched DNA Binding Regulation Of Immature T Cell Proliferation In Thymus ATP-dependent DNA Damage Sensor Activity Cellular Response To Stress Apoptotic Signaling Pathway Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Mitotic Cell Cycle Phase Transition Protein Serine Kinase Activity Nucleoplasm Disordered Domain Specific Binding Response To Stress Negative Regulation Of Multicellular Organismal Process Regulation Of T Cell Differentiation In Thymus Cell Population Proliferation Positive Regulation Of Protein Modification Process ERBB2 Signaling Pathway Protein Tyrosine Kinase Activity Synaptonemal Complex Negative Regulation Of Epithelial Cell Proliferation Regulation Of Protein Phosphorylation Reciprocal Meiotic Recombination Protein Serine/threonine Kinase Activity Regulation Of Cell Growth Nucleus Regulation Of Phosphorylation Signal Transduction Positive Regulation Of Protein Metabolic Process Intrinsic Apoptotic Signaling Pathway Regulation Of Cell Cycle Phase Transition Condensed Chromosome Epithelial Cell Proliferation Homologous Recombination Chromatin Binding Apoptotic Process Positive Regulation Of Epithelial Cell Proliferation	Mismatch Repair Fructose 1,6-bisphosphate Metabolic Process Mismatched DNA Binding Fructose Metabolic Process Canonical Wnt Signaling Pathway Phosphoric Ester Hydrolase Activity Fructose 1,6-bisphosphate 1-phosphatase Activity Reproductive Process Gluconeogenesis Carbohydrate Biosynthetic Process ATP-dependent DNA Damage Sensor Activity Hexose Biosynthetic Process Positive Regulation Of MiRNA Metabolic Process Positive Regulation Of Deoxyribonuclease Activity Regulation Of Protein Localization To Synapse Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Protein Localization To Cell Periphery Insulin-like Growth Factor Receptor Signaling Pathway Enzyme Binding Regulation Of Protein Localization To Membrane Negative Regulation Of Phosphate Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Regulation Of MiRNA Metabolic Process DNA Repair Cellular Response To Radiation Positive Regulation Of Isotype Switching To IgA Isotypes Cell Population Proliferation DNA Metabolic Process Small Molecule Biosynthetic Process Neural Tube Development Cellular Response To Stress Somatic Cell DNA Recombination Negative Regulation Of Small Molecule Metabolic Process Regulation Of Small Molecule Metabolic Process Regulation Of Ras Protein Signal Transduction Response To Steroid Hormone Response To Ketone Meiotic Cell Cycle Tube Development Male Germ Cell Nucleus Negative Regulation Of Striated Muscle Tissue Development Glucose Metabolic Process Osteoblast Differentiation Response To Stress Regulation Of Generation Of Precursor Metabolites And Energy Response To Oxidative Stress Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of MiRNA Transcription MAPK Cascade Animal Organ Regeneration
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