CYLC2 and MUTYH

Number of citations: 0 (PubMedID 24412244)
Data Source: BioGRID (two hybrid)

		CYLC2	MUTYH
Name		cylicin 2	mutY DNA glycosylase
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytoskeleton Perinuclear Theca Cytoskeletal Calyx	Nucleus Nucleoplasm Mitochondrion
	Molecular Function	Structural Constituent Of Cytoskeleton	Purine-specific Mismatch Base Pair DNA N-glycosylase Activity DNA Binding Catalytic Activity Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds DNA N-glycosylase Activity Oxidized Purine DNA Binding MutLalpha Complex Binding MutLbeta Complex Binding MutSalpha Complex Binding MutSbeta Complex Binding 8-oxo-7,8-dihydroguanine DNA N-glycosylase Activity Adenine/guanine Mispair Binding Metal Ion Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Cytoskeleton Organization Spermatogenesis Cell Differentiation	DNA Repair Base-excision Repair Mismatch Repair Response To Stress DNA Damage Response Depurination Negative Regulation Of Necroptotic Process
Diseases		None	Familial adenomatous polyposis
GWAS		Chronic rhinosinusitis ( 33393196 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Metabolite levels ( 23823483 ) Obesity-related traits ( 23251661 ) Tourette's syndrome or obsessive-compulsive disorder ( 25158072 )	Composite immunoglobulin trait (IgA/IgM) ( 28628107 ) Periventricular white matter hyperintensities ( 32517579 )
Novel Interactors		1 novel interactors: ERP44	1 novel interactors: TNFRSF9
Interacting Genes		13 interacting genes: AURKA BUB1 CDKN2A EGFR ERBB2 MAP2K4 MCC MLH1 MLH3 MUTYH NRAS SMAD2 STK11	19 interacting genes: AGTRAP APEX1 BAAT CYLC2 FANCC HRAS LMNA LRSAM1 MSANTD3 MSH6 PCNA RPA1 RPA4 SEC61B SIRT6 SMAD1 TDRD7 TSTD2 XPA
Entrez ID		1539	4595
HPRD ID		04945	05380
Ensembl ID		ENSG00000155833	ENSG00000132781
Uniprot IDs		Q14093 Q6PEJ5	A0AAQ5BGW7 E5KP25 E5KP26 E5KP27 E5KP28 E9PM53 E9PP34 Q9UIF7
PDB IDs		Not available	1X51 3N5N 8FAY
GO Terms Enriched among Interactors		Regulation Of Epithelial Cell Proliferation Chiasma Protein Kinase Activity Intracellular Signal Transduction Mismatch Repair ATP Binding Kinase Activity Negative Regulation Of Immature T Cell Proliferation In Thymus Mismatch Repair Complex Negative Regulation Of Immature T Cell Proliferation MutSalpha Complex Binding Nucleotide Binding ERBB2-EGFR Signaling Pathway Negative Regulation Of T Cell Differentiation In Thymus Intracellular Signaling Cassette Mismatched DNA Binding Regulation Of Immature T Cell Proliferation In Thymus ATP-dependent DNA Damage Sensor Activity Cellular Response To Stress Apoptotic Signaling Pathway Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Mitotic Cell Cycle Phase Transition Protein Serine Kinase Activity Nucleoplasm Disordered Domain Specific Binding Response To Stress Negative Regulation Of Multicellular Organismal Process Regulation Of T Cell Differentiation In Thymus Cell Population Proliferation Positive Regulation Of Protein Modification Process ERBB2 Signaling Pathway Protein Tyrosine Kinase Activity Synaptonemal Complex Negative Regulation Of Epithelial Cell Proliferation Regulation Of Protein Phosphorylation Reciprocal Meiotic Recombination Protein Serine/threonine Kinase Activity Regulation Of Cell Growth Nucleus Regulation Of Phosphorylation Signal Transduction Positive Regulation Of Protein Metabolic Process Intrinsic Apoptotic Signaling Pathway Regulation Of Cell Cycle Phase Transition Condensed Chromosome Epithelial Cell Proliferation Homologous Recombination Chromatin Binding Apoptotic Process Positive Regulation Of Epithelial Cell Proliferation	Damaged DNA Binding Base-excision Repair DNA Repair Nucleotide-excision Repair DNA Replication Factor A Complex DNA Metabolic Process DNA Damage Response Chromosome, Telomeric Region Cellular Response To Stress Mismatch Repair Site Of Double-strand Break Response To Stress Response To UV MutLalpha Complex Binding Male Germ Cell Nucleus Chromosome Organization Nuclear Lamina Base-excision Repair, Gap-filling Response To Radiation DNA Recombination Telomere Maintenance Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Chromatin Organization Telomere Organization Protein Localization To Site Of Double-strand Break Response To Light Stimulus DNA Replication Protein Localization To Organelle Determination Of Adult Lifespan Phosphodiesterase Activity, Acting On 3'-phosphoglycolate-terminated DNA Strands Class II DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Telomere Maintenance Via Base-excision Repair Glycine N-choloyltransferase Activity Bile Acid Conjugation Meiotic Mismatch Repair Intrinsic Apoptotic Signaling Pathway Cellular Response To Radiation Protein Localization To Nucleus PCNA Complex Replisome Site Of DNA Damage Nucleotide-excision Repair, DNA Damage Recognition Endoplasmic Reticulum Sec Complex Histone H3K56 Deacetylase Activity, NAD-dependent Negative Regulation Of Cell Population Proliferation DNA-(abasic Site) Binding Nucleoplasm Double-stranded DNA Exodeoxyribonuclease Activity Deoxyribonuclease (pyrimidine Dimer) Activity