CYLC2 and BUB1

Number of citations: 0 (PubMedID 24412244)
Data Source: BioGRID (two hybrid)

		CYLC2	BUB1
Name		cylicin 2	BUB1 mitotic checkpoint serine/threonine kinase
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytoskeleton Perinuclear Theca Cytoskeletal Calyx	Chromosome, Centromeric Region Kinetochore Outer Kinetochore Nucleus Nucleoplasm Chromosome Cytosol Membrane
	Molecular Function	Structural Constituent Of Cytoskeleton	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity Histone H2A Kinase Activity
	Biological Process	Cytoskeleton Organization Spermatogenesis Cell Differentiation	Chromatin Remodeling Apoptotic Process Chromosome Segregation Regulation Of Sister Chromatid Cohesion Mitotic Spindle Assembly Checkpoint Signaling Intracellular Signal Transduction Cell Division Meiotic Sister Chromatid Cohesion, Centromeric Regulation Of Chromosome Segregation Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric
Pathways		None	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
GWAS		Chronic rhinosinusitis ( 33393196 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Metabolite levels ( 23823483 ) Obesity-related traits ( 23251661 ) Tourette's syndrome or obsessive-compulsive disorder ( 25158072 )	No GWAS studies recorded
Novel Interactors		1 novel interactors: ERP44	None recorded
Interacting Genes		13 interacting genes: AURKA BUB1 CDKN2A EGFR ERBB2 MAP2K4 MCC MLH1 MLH3 MUTYH NRAS SMAD2 STK11	64 interacting genes: AKT1 ALDOB ANP32B AOPEP AP1B1 AP2B1 AP3B1 AP4B1 APC ARIH2 BAAT BUB3 CCDC180 CDC14B CDC20 CDK1 CDK8 CORO2A CRK CTSV CYLC2 DVL1 EIF4EBP1 FANCC FBP1 FBP2 FBXO7 FRAT2 GALNT12 HDAC1 HEMGN HRAS HSD17B3 IGFBP3 KNL1 LEF1 MAP2K1 MAPK3 MSANTD3 NANS PLK1 PPP2CB PPP3R2 RAE1 RASA1 RDH12 SEC61B SFRP2 SFRP4 SHC1 SMAD1 STX17 SVIL TBC1D2 TDRD7 TGFB1 TMEFF1 TMOD1 TRMO TSTD2 UBC XPA ZNF189 ZNF510
Entrez ID		1539	699
HPRD ID		04945	03907
Ensembl ID		ENSG00000155833	ENSG00000169679
Uniprot IDs		Q14093 Q6PEJ5	B4DYG2 O43683
PDB IDs		Not available	2LAH 4A1G 4QPM 4R8Q 5DMZ 6F7B 7B1F 7B1H 7B1J
GO Terms Enriched among Interactors		Regulation Of Epithelial Cell Proliferation Chiasma Protein Kinase Activity Intracellular Signal Transduction Mismatch Repair ATP Binding Kinase Activity Negative Regulation Of Immature T Cell Proliferation In Thymus Mismatch Repair Complex Negative Regulation Of Immature T Cell Proliferation MutSalpha Complex Binding Nucleotide Binding ERBB2-EGFR Signaling Pathway Negative Regulation Of T Cell Differentiation In Thymus Intracellular Signaling Cassette Mismatched DNA Binding Regulation Of Immature T Cell Proliferation In Thymus ATP-dependent DNA Damage Sensor Activity Cellular Response To Stress Apoptotic Signaling Pathway Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Mitotic Cell Cycle Phase Transition Protein Serine Kinase Activity Nucleoplasm Disordered Domain Specific Binding Response To Stress Negative Regulation Of Multicellular Organismal Process Regulation Of T Cell Differentiation In Thymus Cell Population Proliferation Positive Regulation Of Protein Modification Process ERBB2 Signaling Pathway Protein Tyrosine Kinase Activity Synaptonemal Complex Negative Regulation Of Epithelial Cell Proliferation Regulation Of Protein Phosphorylation Reciprocal Meiotic Recombination Protein Serine/threonine Kinase Activity Regulation Of Cell Growth Nucleus Regulation Of Phosphorylation Signal Transduction Positive Regulation Of Protein Metabolic Process Intrinsic Apoptotic Signaling Pathway Regulation Of Cell Cycle Phase Transition Condensed Chromosome Epithelial Cell Proliferation Homologous Recombination Chromatin Binding Apoptotic Process Positive Regulation Of Epithelial Cell Proliferation	Clathrin Adaptor Complex Regulation Of Organelle Organization Regulation Of Cellular Component Organization Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Ubiquitin Protein Ligase Activity Regulation Of Cell Cycle Membrane Coat Cytosol Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Fructose 1,6-bisphosphate Metabolic Process Regulation Of Sister Chromatid Segregation Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Cytoskeleton Organization Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Sister Chromatid Separation Canonical Wnt Signaling Pathway Regulation Of Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Chromosome Separation Regulation Of Chromosome Segregation Insulin Receptor Signaling Pathway Negative Regulation Of Mitotic Cell Cycle Protein Localization To Kinetochore Positive Regulation Of Ubiquitin-protein Transferase Activity Phosphoric Ester Hydrolase Activity Fructose 1,6-bisphosphate 1-phosphatase Activity Golgi Inheritance Negative Regulation Of Mitotic Nuclear Division Intracellular Signal Transduction Fructose Metabolic Process Negative Regulation Of Cell Cycle Phase Transition Regulation Of Cellular Localization Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Protein Localization Regulation Of Plasma Membrane Bounded Cell Projection Organization Phosphotyrosine Residue Binding Regulation Of Cell Projection Organization Regulation Of Chromosome Organization Positive Regulation Of Protein Localization Protein Kinase Binding Regulation Of Protein Localization To Membrane Gluconeogenesis Schwann Cell Development Negative Regulation Of Cell Cycle