ADRA2A and SNTA1

Number of citations of the paper that reports this interaction (PubMedID 15123239)
0

Data Source:
BioGRID (unspecified method)

		ADRA2A	SNTA1
Description		adrenoceptor alpha 2A	syntrophin alpha 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane Basolateral Plasma Membrane Neuronal Cell Body Receptor Complex Axon Terminus Postsynaptic Membrane Presynaptic Active Zone Membrane Dopaminergic Synapse Postsynaptic Density Membrane Glutamatergic Synapse GABA-ergic Synapse	Cytoplasm Cytoskeleton Plasma Membrane Dystrophin-associated Glycoprotein Complex Syntrophin Complex Membrane Lateral Plasma Membrane Neuromuscular Junction Protein-containing Complex Sarcolemma Anchoring Junction
	Molecular Function	G Protein-coupled Receptor Activity Adrenergic Receptor Activity Alpha2-adrenergic Receptor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Protein Kinase Binding Alpha-1B Adrenergic Receptor Binding Alpha-2C Adrenergic Receptor Binding Thioesterase Binding Heterotrimeric G-protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Epinephrine Binding Norepinephrine Binding	Actin Binding Structural Molecule Activity Protein Binding Calmodulin Binding Sodium Channel Regulator Activity PDZ Domain Binding Transmembrane Transporter Binding Nitric-oxide Synthase Binding ATPase Binding
	Biological Process	Positive Regulation Of Cytokine Production DNA Replication Regulation Of Smooth Muscle Contraction Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Ras Protein Signal Transduction Rho Protein Signal Transduction Female Pregnancy Positive Regulation Of Cell Population Proliferation Negative Regulation Of Norepinephrine Secretion Regulation Of Vasoconstriction Actin Cytoskeleton Organization Platelet Activation Positive Regulation Of Cell Migration Negative Regulation Of Epinephrine Secretion Cellular Response To Hormone Stimulus Vasodilation Glucose Homeostasis Fear Response Positive Regulation Of Potassium Ion Transport Response To Morphine Positive Regulation Of MAPK Cascade Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Calcium Ion-dependent Exocytosis Negative Regulation Of Insulin Secretion Intestinal Absorption Thermoception Negative Regulation Of Lipid Catabolic Process Positive Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Calcium Ion Transport Negative Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Negative Regulation Of Uterine Smooth Muscle Contraction Adrenergic Receptor Signaling Pathway Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway Phospholipase C-activating Adrenergic Receptor Signaling Pathway Positive Regulation Of Wound Healing Response To Alcohol Presynaptic Modulation Of Chemical Synaptic Transmission	Regulation Of Heart Rate Muscle Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Ventricular Cardiac Muscle Cell Action Potential Regulation Of Sodium Ion Transmembrane Transport
Pathways		Adrenoceptors Adrenaline signalling through Alpha-2 adrenergic receptor Adrenaline,noradrenaline inhibits insulin secretion G alpha (i) signalling events G alpha (z) signalling events Surfactant metabolism	Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)
Drugs		Amphetamine Tramadol Bethanidine Ziprasidone Cabergoline Ropinirole Dihydroergotamine Dihydroergotamine Amitriptyline Clozapine Norepinephrine Mirtazapine Phenylpropanolamine Loxapine Pramipexole Prochlorperazine Dipivefrin Prazosin Chlorpromazine Brimonidine Haloperidol Nortriptyline Amoxapine Amoxapine Lamotrigine Clonidine Lisuride Guanabenz Dexmedetomidine Trazodone Epinephrine Phentolamine Ergotamine Tizanidine Apomorphine Paroxetine Trimipramine Epinastine Tolazoline Fenoldopam Pseudoephedrine Benzphetamine Phenoxybenzamine Maprotiline Oxymetazoline Apraclonidine Methyldopa Guanfacine Ergoloid mesylate Promethazine Carvedilol Nefazodone Desipramine Escitalopram Pergolide Bromocriptine Quetiapine Aripiprazole Paliperidone Ephedra sinica root Mephentermine Yohimbine Methotrimeprazine 4-Methoxyamphetamine Dextroamphetamine Metamfetamine Periciazine Zuclopenthixol Celiprolol Dronedarone Lofexidine Epicept NP-1 Mianserin Pizotifen Asenapine Ocaperidone Droxidopa Flupirtine Esmirtazapine Xylometazoline Levonordefrin Naphazoline Tetryzoline Lurasidone Dosulepin Etoperidone Lorpiprazole Cirazoline Moxisylyte Aranidipine Moxonidine Pirlindole Pipamperone Setiptiline Racepinephrine Dihydroergocornine DL-Methylephedrine DL-Methylephedrine Xylazine Indigotindisulfonic acid Rilmenidine Tiapride Dihydroergocristine Aripiprazole lauroxil
Diseases			Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)
GWAS		Fasting blood glucose ( 20081858 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting glucose ( 34059833) Fish- and plant-related diet ( 32066663) Homeostasis model assessment of beta-cell function ( 20081858) Longitudinal alcohol consumption ( 26081443) Platelet aggregation ( 20526338 29185836)	HDL cholesterol x physical activity interaction (1df test) ( 30670697) HDL cholesterol x physical activity interaction (2df test) ( 30670697)
Interacting Genes		14 interacting genes: ADRB1 EIF2B1 GGA3 GNAI1 GNAI2 GNAO1 GNB1 GNG2 GRK2 PPP1R9B PRKCD SNTA1 UCHL1 YWHAZ	76 interacting genes: ABCA1 ABCC4 ACTA2 ADAMTS6 ADGRB1 ADGRB2 ADGRB3 ADH5 ADRA1D ADRA2A ADRB1 AGTR2 ATP2B2 ATP6V0B C3AR1 CALM1 CD3E CNKSR2 COPB1 DGKZ DMD DTNA DTNB ENTREP3 F8A1 FABP1 GDA GLS GLS2 GOLGA2 GRB2 GUCY1A2 HTR2B HTR2C IL2RA IL9 ITGB5 KCNA4 KCNA5 KCNJ10 KCNJ12 KCNJ15 KCNJ4 KIF1B LMO1 MAP4 MAPK12 MAS1 MAST1 MCM7 MED8 MTMR2 NAT1 NMU NOS1 PFN2 PRLHR PSKH1 RPS6KA1 SCN1A SCN4A SCN5A SCTR SLC16A7 SLC1A7 SLC2A3 SLC6A3 SSTR1 TGFA TIAM1 TLX3 TRA TRBV12-3 UTRN VANGL2 XRCC6
Entrez ID		150	6640
HPRD ID		00078	03009
Ensembl ID		ENSG00000150594	ENSG00000101400
Uniprot IDs		P08913	B3KTR0 Q13424
PDB IDs		1HLL 1HO9 1HOD 1HOF 6K42 6KUX 6KUY 7EJ0 7EJ8 7EJA 7EJK 7W6P 7W7E 9CBL 9CBM
Enriched GO Terms of Interacting Partners?		Heterotrimeric G-protein Complex Alpha-2A Adrenergic Receptor Binding Response To Prostaglandin E Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Guanyl Nucleotide Binding System Process G Protein-coupled Acetylcholine Receptor Signaling Pathway G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Dopamine Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Plasma Membrane D2 Dopamine Receptor Binding G Protein-coupled Serotonin Receptor Binding Adenylate Cyclase Regulator Activity Acetylcholine Receptor Signaling Pathway Response To Hormone Regulation Of The Force Of Heart Contraction By Chemical Signal Postsynaptic Signal Transduction Positive Regulation Of Protein Localization To Cell Cortex Regulation Of Heart Contraction Membrane Regulation Of Protein Localization To Cell Cortex G Protein-coupled Receptor Binding Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Response To Ketone Cellular Response To Lipid Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Blood Circulation Response To Alcohol Regulation Of System Process Regulation Of Biological Quality Regulation Of Relaxation Of Muscle Signal Transduction Cellular Response To Catecholamine Stimulus Negative Regulation Of Cell Communication Negative Regulation Of Signaling GTPase Activity Positive Regulation Of Superoxide Anion Generation Cellular Response To Prostaglandin E Stimulus Response To Catecholamine G Protein-coupled Serotonin Receptor Signaling Pathway Regulation Of Superoxide Anion Generation Neuronal Dense Core Vesicle Regulation Of MAPK Cascade Cellular Response To Prostaglandin Stimulus Transmembrane Transporter Binding Regulation Of The Force Of Heart Contraction Negative Regulation Of Secretion By Cell	Plasma Membrane System Process Regulation Of System Process Membrane G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Regulation Of Blood Circulation Circulatory System Process Vascular Process In Circulatory System Monoatomic Ion Channel Complex Regulation Of Multicellular Organismal Process Regulation Of Heart Contraction Blood Vessel Diameter Maintenance Regulation Of Tube Size Basolateral Plasma Membrane Monoatomic Ion Transmembrane Transport Regulation Of Biological Quality Transmembrane Transport Muscle Contraction Inorganic Ion Transmembrane Transport Metal Ion Transport Monoatomic Ion Transport Regulation Of Heart Rate Inorganic Cation Transmembrane Transport Regulation Of Membrane Potential Monoatomic Cation Transmembrane Transport Monoatomic Cation Transport Cardiac Muscle Cell Action Potential Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Muscle System Process Synapse Inward Rectifier Potassium Channel Activity Synaptic Signaling Vasodilation Intracellular Signaling Cassette Regulation Of Monoatomic Ion Transmembrane Transport Adrenergic Receptor Activity CGMP-mediated Signaling Calcium-mediated Signaling Action Potential Potassium Ion Transport Regulation Of Blood Pressure Regulation Of Muscle Contraction Regulation Of Monoatomic Ion Transport Voltage-gated Sodium Channel Complex Signal Transduction Angiotensin-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Multicellular Organismal Process
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