ADRA2A and ADRB1

Number of citations of the paper that reports this interaction (PMID 12529373)
22

Data Source:
HPRD (in vivo)

		ADRA2A	ADRB1
Gene Name		adrenoceptor alpha 2A	adrenoceptor beta 1
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Basolateral Plasma Membrane Receptor Complex Synapse	Nucleus Early Endosome Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Alpha2-adrenergic Receptor Activity Protein Binding Protein Kinase Binding Alpha-1B Adrenergic Receptor Binding Alpha-2C Adrenergic Receptor Binding Thioesterase Binding Heterotrimeric G-protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Epinephrine Binding Norepinephrine Binding	Beta-adrenergic Receptor Activity Beta1-adrenergic Receptor Activity Receptor Signaling Protein Activity Ras Guanyl-nucleotide Exchange Factor Activity Protein Binding Drug Binding PDZ Domain Binding Alpha-2A Adrenergic Receptor Binding Dopamine Binding Protein Heterodimerization Activity Epinephrine Binding Norepinephrine Binding
	Biological Process	Positive Regulation Of Cytokine Production Acute Inflammatory Response Energy Reserve Metabolic Process DNA Replication Movement Of Cell Or Subcellular Component Signal Transduction G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Ras Protein Signal Transduction Rho Protein Signal Transduction Female Pregnancy Blood Coagulation Positive Regulation Of Cell Proliferation Negative Regulation Of Norepinephrine Secretion Regulation Of Vasoconstriction Actin Cytoskeleton Organization Platelet Activation Positive Regulation Of Cell Migration Negative Regulation Of CAMP Biosynthetic Process Activation Of Protein Kinase Activity Activation Of Protein Kinase B Activity Negative Regulation Of Epinephrine Secretion Cellular Response To Hormone Stimulus Epidermal Growth Factor-activated Receptor Transactivation By G-protein Coupled Receptor Signaling Pathway Glucose Homeostasis Fear Response Positive Regulation Of Potassium Ion Transport Positive Regulation Of MAP Kinase Activity Small Molecule Metabolic Process Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Positive Regulation Of Vasodilation Negative Regulation Of Calcium Ion-dependent Exocytosis Negative Regulation Of Insulin Secretion Regulation Of Insulin Secretion Intestinal Absorption Thermoception Negative Regulation Of Lipid Catabolic Process Positive Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Calcium Ion Transport Negative Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Negative Regulation Of Uterine Smooth Muscle Contraction Negative Regulation Of Adrenergic Receptor Signaling Pathway Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway Phospholipase C-activating Adrenergic Receptor Signaling Pathway Activation Of MAPK Activity By Adrenergic Receptor Signaling Pathway Positive Regulation Of Wound Healing Negative Regulation Of Calcium Ion Transmembrane Transporter Activity	Positive Regulation Of Heart Rate By Epinephrine-norepinephrine Diet Induced Thermogenesis Vasodilation By Norepinephrine-epinephrine Involved In Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of The Force Of Heart Contraction By Norepinephrine Positive Regulation Of Systemic Arterial Blood Pressure Glycogen Catabolic Process Apoptotic Process Activation Of Adenylate Cyclase Activity Rho Protein Signal Transduction Aging Memory Response To Cold Sensory Perception Of Pain Positive Regulation Of CAMP Biosynthetic Process Heat Generation Positive Regulation Of Ras GTPase Activity Protein Localization To Organelle Negative Regulation Of Urine Volume Negative Regulation Of Multicellular Organism Growth Wound Healing Fear Response Positive Regulation Of Apoptotic Process Positive Regulation Of CAMP-mediated Signaling Negative Regulation Of Smooth Muscle Contraction Positive Regulation Of Saliva Secretion Brown Fat Cell Differentiation Regulation Of Calcium Ion Transport Lipid Homeostasis Regulation Of Inhibitory Postsynaptic Membrane Potential Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Regulation Of Cardiac Muscle Cell Contraction Positive Regulation Of Renin Secretion Into Blood Stream Positive Regulation Of Cation Channel Activity
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Integration of energy metabolism Adrenaline signalling through Alpha-2 adrenergic receptor Class A/1 (Rhodopsin-like receptors) Regulation of insulin secretion Amine ligand-binding receptors Platelet Aggregation (Plug Formation) Metabolic disorders of biological oxidation enzymes GPCR ligand binding Adrenaline,noradrenaline inhibits insulin secretion GPCR downstream signaling Adrenoceptors G alpha (z) signalling events G alpha (i) signalling events Platelet activation, signaling and aggregation	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Adrenoceptors Class A/1 (Rhodopsin-like receptors) Amine ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs		Bethanidine Ziprasidone Cabergoline Ropinirole Dihydroergotamine Amitriptyline Olanzapine Clozapine Norepinephrine Mirtazapine Phenylpropanolamine Pramipexole Dipivefrin Brimonidine Amoxapine Clonidine Lisuride Guanabenz Dexmedetomidine Trazodone Epinephrine Phentolamine Ergotamine Tizanidine Apomorphine Risperidone Epinastine Tolazoline Fenoldopam Pseudoephedrine Benzphetamine Phenoxybenzamine Oxymetazoline Apraclonidine Methyldopa Guanfacine Ergoloid mesylate Doxepin Nefazodone Pergolide Bromocriptine Quetiapine Aripiprazole Paliperidone Dihydroergotoxine Ephedra Yohimbine Methotrimeprazine 4-Methoxyamphetamine Methamphetamine Propericiazine Zuclopenthixol Dronedarone Lofexidine Mianserin Asenapine Droxidopa Xylometazoline Naphazoline Lurasidone	Esmolol Betaxolol Isoetharine Metoprolol Atenolol Norepinephrine Timolol Phenylpropanolamine Sotalol Carteolol Propranolol Labetalol Bisoprolol Epinephrine Dobutamine Pseudoephedrine Alprenolol Pindolol Salbutamol Isoproterenol Arbutamine Amiodarone Carvedilol Desipramine Acebutolol Nadolol Levobunolol Metipranolol Fenoterol Pirbuterol Bevantolol Practolol Penbutolol Ephedra Clenbuterol Oxprenolol Dronedarone Nebivolol Asenapine Droxidopa 4-{[(2S)-3-(tert-butylamino)-2-hydroxypropyl]oxy}-3H-indole-2-carbonitrile 2-HYDROXYMETHYL-6-OCTYLSULFANYL-TETRAHYDRO-PYRAN-3,4,5-TRIOL Bopindolol Bupranolol
Diseases
GWAS		Fasting glucose-related traits ( 20081858) Fasting glucose-related traits (interaction with BMI) ( 22581228) Platelet aggregation ( 20526338)	Birth weight ( 23202124) Blood pressure ( 21909110) Gaucher disease severity ( 22388998)
Protein-Protein Interactions		13 interactors: ADRB1 ADRBK1 EIF2B1 GNAI1 GNAI2 GNAO1 GNB1 GNG2 PPP1R9B PRKCD SNTA1 UCHL1 YWHAZ	16 interactors: ADRA2A ARRB1 DLG1 DLG4 DLGAP2 GIPC1 GOPC GPRASP1 GPRASP2 GRB2 MAGI2 MAGI3 NOS1 SH3GL2 SH3GL3 SNTA1
Entrez ID		150	153
HPRD ID		00078	00181
Ensembl ID		ENSG00000150594	ENSG00000043591
Uniprot IDs		P08913	P08588
PDB IDs		1HLL 1HO9 1HOD 1HOF	2LSQ
Enriched GO Terms of Interacting Partners?		Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Platelet Activation Regulation Of Body Fluid Levels Wound Healing Response To Wounding Response To Stress Blood Coagulation G-protein Coupled Acetylcholine Receptor Signaling Pathway Hemostasis Cell Activation Dopamine Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Regulation Of Heart Contraction Response To Organonitrogen Compound Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling Cell Communication Regulation Of Catalytic Activity Regulation Of The Force Of Heart Contraction By Chemical Signal Synaptic Transmission Response To Organic Substance Regulation Of Ion Transport Regulation Of Striated Muscle Contraction Cellular Response To Prostaglandin E Stimulus Response To Stimulus Regulation Of Signal Transduction Cell Proliferation Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Cellular Response To Stimulus Signal Transduction Cellular Response To Prostaglandin Stimulus Response To Prostaglandin E Energy Reserve Metabolic Process Regulation Of Signaling Cell Surface Receptor Signaling Pathway Negative Regulation Of Muscle Contraction Signaling Regulation Of Muscle Contraction Positive Regulation Of Catalytic Activity Response To Peptide Hormone Cellular Response To Catecholamine Stimulus Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Response To Peptide Regulation Of The Force Of Heart Contraction Regulation Of Cellular Process Regulation Of Calcium Ion Transport Positive Regulation Of Hydrolase Activity Response To Morphine Cellular Response To Glucagon Stimulus	Regulation Of Receptor Internalization Regulation Of Signal Transduction Regulation Of Vesicle-mediated Transport Negative Regulation Of Signal Transduction Regulation Of Signaling Negative Regulation Of Signaling Post-Golgi Vesicle-mediated Transport Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of Adrenergic Receptor Signaling Pathway Regulation Of Sodium Ion Transmembrane Transport Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Receptor Clustering Regulation Of Ion Transmembrane Transport Regulation Of Endocytosis Regulation Of Adrenergic Receptor Signaling Pathway Nucleotide Phosphorylation Signaling Regulation Of Cellular Component Organization Regulation Of Potassium Ion Transport Cell Communication Receptor Localization To Synapse Regulation Of Sodium Ion Transport Cell-cell Signaling Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Intracellular Transport Regulation Of ERBB Signaling Pathway Positive Regulation Of Catalytic Activity Receptor Metabolic Process Golgi Vesicle Transport Synaptic Transmission Regulation Of Ion Transport Regulation Of Catalytic Activity Cellular Localization Endocytosis Regulation Of Intracellular Signal Transduction Protein Localization To Synapse Positive Regulation Of Transport Positive Regulation Of Receptor Internalization Locomotion Positive Regulation Of Signal Transduction Axon Guidance Positive Regulation Of Histone Acetylation Negative Regulation Of Transport Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Ion Transmembrane Transporter Activity Positive Regulation Of Organelle Organization Regulation Of Transmembrane Transporter Activity
Tagcloud ?		adrenergic arg347cys bk2r check chronotropic dbp enos exercise glu298asp melting neurohumoral nitric overt paulo polymorphisms programme reserve rs1048101 rs1799983 rs2070744 rs28365031 rs553668 rs5810761 sao sbp synthase treadmill	alpha5 appl1 assembles cargoes deafness dimerizing drd2 factorbeta gh1 gh2 gipc gipc1 gipc2 gipc3 gipcs gpcrs hbc lrp1 myo6 nonsyndromic nrp1 ntrk1 pdz rgs19 rtks sdc4 sema4c tgfbetar3 vangl2
Tagcloud (Difference) ?		adrenergic arg347cys bk2r check chronotropic dbp enos exercise glu298asp melting neurohumoral nitric overt paulo polymorphisms programme reserve rs1048101 rs1799983 rs2070744 rs28365031 rs553668 rs5810761 sao sbp synthase treadmill	alpha5 appl1 assembles cargoes deafness dimerizing drd2 factorbeta gh1 gh2 gipc gipc1 gipc2 gipc3 gipcs gpcrs hbc lrp1 myo6 nonsyndromic nrp1 ntrk1 pdz rgs19 rtks sdc4 sema4c tgfbetar3 vangl2
Tagcloud (Intersection) ?