ADRA2A and PRKCD

Number of citations of the paper that reports this interaction (PMID 11732925)
1

Data Source:
HPRD (in vitro)

		ADRA2A	PRKCD
Gene Name		adrenoceptor alpha 2A	protein kinase C, delta
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Basolateral Plasma Membrane Receptor Complex Synapse	Nucleus Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Plasma Membrane Cell-cell Junction Nuclear Matrix Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Alpha2-adrenergic Receptor Activity Protein Binding Protein Kinase Binding Alpha-1B Adrenergic Receptor Binding Alpha-2C Adrenergic Receptor Binding Thioesterase Binding Heterotrimeric G-protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Epinephrine Binding Norepinephrine Binding	Protein Serine/threonine Kinase Activity Protein Kinase C Activity Calcium-independent Protein Kinase C Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Enzyme Activator Activity Enzyme Binding Insulin Receptor Substrate Binding Metal Ion Binding
	Biological Process	Positive Regulation Of Cytokine Production Acute Inflammatory Response Energy Reserve Metabolic Process DNA Replication Movement Of Cell Or Subcellular Component Signal Transduction G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Ras Protein Signal Transduction Rho Protein Signal Transduction Female Pregnancy Blood Coagulation Positive Regulation Of Cell Proliferation Negative Regulation Of Norepinephrine Secretion Regulation Of Vasoconstriction Actin Cytoskeleton Organization Platelet Activation Positive Regulation Of Cell Migration Negative Regulation Of CAMP Biosynthetic Process Activation Of Protein Kinase Activity Activation Of Protein Kinase B Activity Negative Regulation Of Epinephrine Secretion Cellular Response To Hormone Stimulus Epidermal Growth Factor-activated Receptor Transactivation By G-protein Coupled Receptor Signaling Pathway Glucose Homeostasis Fear Response Positive Regulation Of Potassium Ion Transport Positive Regulation Of MAP Kinase Activity Small Molecule Metabolic Process Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Positive Regulation Of Vasodilation Negative Regulation Of Calcium Ion-dependent Exocytosis Negative Regulation Of Insulin Secretion Regulation Of Insulin Secretion Intestinal Absorption Thermoception Negative Regulation Of Lipid Catabolic Process Positive Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Calcium Ion Transport Negative Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Negative Regulation Of Uterine Smooth Muscle Contraction Negative Regulation Of Adrenergic Receptor Signaling Pathway Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway Phospholipase C-activating Adrenergic Receptor Signaling Pathway Activation Of MAPK Activity By Adrenergic Receptor Signaling Pathway Positive Regulation Of Wound Healing Negative Regulation Of Calcium Ion Transmembrane Transporter Activity	Protein Phosphorylation Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cell Cycle Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Activation Of Phospholipase C Activity Blood Coagulation Fibroblast Growth Factor Receptor Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Gene Expression Regulation Of Receptor Activity Immunoglobulin Mediated Immune Response Peptidyl-threonine Phosphorylation Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Termination Of Signal Transduction Platelet Activation Negative Regulation Of Actin Filament Polymerization Negative Regulation Of Protein Binding Interleukin-10 Production Interleukin-12 Production Positive Regulation Of Superoxide Anion Generation Negative Regulation Of Glial Cell Apoptotic Process Positive Regulation Of Protein Dephosphorylation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis B Cell Proliferation Neutrophil Activation Defense Response To Bacterium Negative Regulation Of MAP Kinase Activity Innate Immune Response Negative Regulation Of Insulin Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Inflammatory Response Negative Regulation Of Peptidyl-tyrosine Phosphorylation Protein Stabilization Negative Regulation Of Filopodium Assembly Interferon-gamma-mediated Signaling Pathway Negative Regulation Of Platelet Aggregation Cellular Senescence Positive Regulation Of Phospholipid Scramblase Activity Positive Regulation Of Ceramide Biosynthetic Process Positive Regulation Of Glucosylceramide Catabolic Process Positive Regulation Of Sphingomyelin Catabolic Process Positive Regulation Of Response To DNA Damage Stimulus Positive Regulation Of Apoptotic Signaling Pathway
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Integration of energy metabolism Adrenaline signalling through Alpha-2 adrenergic receptor Class A/1 (Rhodopsin-like receptors) Regulation of insulin secretion Amine ligand-binding receptors Platelet Aggregation (Plug Formation) Metabolic disorders of biological oxidation enzymes GPCR ligand binding Adrenaline,noradrenaline inhibits insulin secretion GPCR downstream signaling Adrenoceptors G alpha (z) signalling events G alpha (i) signalling events Platelet activation, signaling and aggregation	Ca-dependent events Signaling by GPCR CaM pathway Phospholipase C-mediated cascade Signaling by FGFR in disease Signaling by EGFRvIII in Cancer PLCG1 events in ERBB2 signaling Effects of PIP2 hydrolysis Interferon gamma signaling DAP12 signaling Gastrin-CREB signalling pathway via PKC and MAPK G alpha (z) signalling events Role of phospholipids in phagocytosis Fcgamma receptor (FCGR) dependent phagocytosis Signaling by PDGF Calmodulin induced events Regulation of mRNA stability by proteins that bind AU-rich elements Apoptotic cleavage of cellular proteins DAP12 interactions Opioid Signalling EGFR interacts with phospholipase C-gamma Signaling by ERBB2 G alpha (q) signalling events Signaling by EGFR GPCR downstream signaling Signaling by VEGF Calmodulin induced events Downstream signal transduction Signaling by EGFR in Cancer Platelet activation, signaling and aggregation G alpha (q) signalling events HuR stabilizes mRNA DAG and IP3 signaling VEGFA-VEGFR2 Pathway CaM pathway VEGFR2 mediated cell proliferation Downstream signaling of activated FGFR Programmed Cell Death Innate Immune System Signalling by NGF PLC beta mediated events Interferon Signaling Apoptotic execution phase Cytokine Signaling in Immune system Signaling by Ligand-Responsive EGFR Variants in Cancer G-protein mediated events NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR PLC-gamma1 signalling
Drugs		Bethanidine Ziprasidone Cabergoline Ropinirole Dihydroergotamine Amitriptyline Olanzapine Clozapine Norepinephrine Mirtazapine Phenylpropanolamine Pramipexole Dipivefrin Brimonidine Amoxapine Clonidine Lisuride Guanabenz Dexmedetomidine Trazodone Epinephrine Phentolamine Ergotamine Tizanidine Apomorphine Risperidone Epinastine Tolazoline Fenoldopam Pseudoephedrine Benzphetamine Phenoxybenzamine Oxymetazoline Apraclonidine Methyldopa Guanfacine Ergoloid mesylate Doxepin Nefazodone Pergolide Bromocriptine Quetiapine Aripiprazole Paliperidone Dihydroergotoxine Ephedra Yohimbine Methotrimeprazine 4-Methoxyamphetamine Methamphetamine Propericiazine Zuclopenthixol Dronedarone Lofexidine Mianserin Asenapine Droxidopa Xylometazoline Naphazoline Lurasidone
Diseases
GWAS		Fasting glucose-related traits ( 20081858) Fasting glucose-related traits (interaction with BMI) ( 22581228) Platelet aggregation ( 20526338)	Bipolar disorder ( 21926972) Ulcerative colitis ( 23128233) Ventricular conduction ( 21076409)
Protein-Protein Interactions		13 interactors: ADRB1 ADRBK1 EIF2B1 GNAI1 GNAI2 GNAO1 GNB1 GNG2 PPP1R9B PRKCD SNTA1 UCHL1 YWHAZ	118 interactors: ACTA1 ACTA2 ACTB ADAM9 ADCY7 ADD1 ADD2 ADRA2A ADRB2 ADRBK1 AFAP1 AKT3 APP ART3 BDKRB2 C1QBP CD34 CDCP1 CHAT CNP CREBBP CYTH1 DAB2 DYNC1H1 EEF1A1 EGFR EIF2S1 ELAVL1 EP300 ESRRA FLI1 FSCN1 FYN GABRA1 GAP43 GNA12 GNA13 GNAZ GNB2L1 GRM5 GSK3A HABP4 HDAC5 HIST1H1A HIST1H1B HNRNPK HSP90AA1 HSPA4 IGF1R IKBKB IL6ST INSR IRS1 ITGA6 ITGB2 ITGB4 ITGB7 ITPR1 KCNJ1 KCNJ4 KLF5 LCK LMNB1 LMNB2 LYN MACF1 MAPK1 MAPK3 MAPT MBP MEP1B MS4A2 MUC1 NCF1 NCF4 NFE2L2 NUMB OPRD1 PAK1 PDP1 PDP2 PDPK1 PEBP1 PIK3CA PIK3CB PLCB1 PLD2 PLSCR1 PLSCR3 PPARA PPM1A PPP1CA PPP2CA PPP2R5C PRKCZ PRKDC PTK2B PTPN22 PTPN6 PTPRA RAC1 RAF1 RASGRP3 RIPK4 RUNX2 SDC4 SHC1 SRC STAT1 STAT3 TAGLN TIAM1 TNFRSF1A VCP VHL YWHAB YWHAG YWHAZ
Entrez ID		150	5580
HPRD ID		00078	01501
Ensembl ID		ENSG00000150594	ENSG00000163932
Uniprot IDs		P08913	Q05655
PDB IDs		1HLL 1HO9 1HOD 1HOF	1YRK 2YUU
Enriched GO Terms of Interacting Partners?		Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Platelet Activation Regulation Of Body Fluid Levels Wound Healing Response To Wounding Response To Stress Blood Coagulation G-protein Coupled Acetylcholine Receptor Signaling Pathway Hemostasis Cell Activation Dopamine Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Regulation Of Heart Contraction Response To Organonitrogen Compound Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling Cell Communication Regulation Of Catalytic Activity Regulation Of The Force Of Heart Contraction By Chemical Signal Synaptic Transmission Response To Organic Substance Regulation Of Ion Transport Regulation Of Striated Muscle Contraction Cellular Response To Prostaglandin E Stimulus Response To Stimulus Regulation Of Signal Transduction Cell Proliferation Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Cellular Response To Stimulus Signal Transduction Cellular Response To Prostaglandin Stimulus Response To Prostaglandin E Energy Reserve Metabolic Process Regulation Of Signaling Cell Surface Receptor Signaling Pathway Negative Regulation Of Muscle Contraction Signaling Regulation Of Muscle Contraction Positive Regulation Of Catalytic Activity Response To Peptide Hormone Cellular Response To Catecholamine Stimulus Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Response To Peptide Regulation Of The Force Of Heart Contraction Regulation Of Cellular Process Regulation Of Calcium Ion Transport Positive Regulation Of Hydrolase Activity Response To Morphine Cellular Response To Glucagon Stimulus	Signaling Cell Communication Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Organic Substance Response To Organic Substance Positive Regulation Of Metabolic Process Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Cellular Response To Peptide Cellular Response To Stimulus Cellular Response To Peptide Hormone Stimulus Defense Response Response To Stress Cellular Response To Organonitrogen Compound Response To Stimulus Platelet Activation Cellular Response To Hormone Stimulus Regulation Of Signal Transduction Immune System Process Positive Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Response To Peptide Response To Hormone Regulation Of Phosphorylation Cellular Response To Growth Factor Stimulus Regulation Of Phosphorus Metabolic Process Innate Immune Response Regulation Of Signaling Response To Peptide Hormone Response To Wounding Vascular Endothelial Growth Factor Receptor Signaling Pathway Response To Growth Factor Wound Healing Cell Activation Positive Regulation Of Protein Metabolic Process Positive Regulation Of Kinase Activity Hemostasis Positive Regulation Of Cellular Protein Metabolic Process Multicellular Organismal Development Positive Regulation Of Protein Modification Process Anatomical Structure Development Positive Regulation Of Protein Phosphorylation Cellular Response To Insulin Stimulus Regulation Of Protein Metabolic Process Regulation Of Kinase Activity Fc Receptor Signaling Pathway Immune Response Response To Insulin
Tagcloud ?		adrenergic arg347cys bk2r check chronotropic dbp enos exercise glu298asp melting neurohumoral nitric overt paulo polymorphisms programme reserve rs1048101 rs1799983 rs2070744 rs28365031 rs553668 rs5810761 sao sbp synthase treadmill	alkenes azotic constructions gnai1 gnao1 heterocycle hm hms htr1b htr2a htr2b htr4 htr6 htr7 kpnb1 pharmacopeia prkaca prkca prkcb prkce prkcg prkd1 propertied pubchem rock2 rps6ka1 rps6ka3 tlr8 tradition
Tagcloud (Difference) ?		adrenergic arg347cys bk2r check chronotropic dbp enos exercise glu298asp melting neurohumoral nitric overt paulo polymorphisms programme reserve rs1048101 rs1799983 rs2070744 rs28365031 rs553668 rs5810761 sao sbp synthase treadmill	alkenes azotic constructions gnai1 gnao1 heterocycle hm hms htr1b htr2a htr2b htr4 htr6 htr7 kpnb1 pharmacopeia prkaca prkca prkcb prkce prkcg prkd1 propertied pubchem rock2 rps6ka1 rps6ka3 tlr8 tradition
Tagcloud (Intersection) ?