ADRA2A and PPP1R9B

Number of citations of the paper that reports this interaction (PMID 11154706)
28

Data Source:
BioGRID (pull down)

		ADRA2A	PPP1R9B
Gene Name		adrenoceptor alpha 2A	protein phosphatase 1, regulatory subunit 9B
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Basolateral Plasma Membrane Receptor Complex Synapse	Protein Phosphatase Type 1 Complex Nucleoplasm Cytoplasm Plasma Membrane Adherens Junction Lamellipodium Filopodium Cortical Actin Cytoskeleton Ruffle Membrane Dendritic Spine Synapse
	Molecular Function	Alpha2-adrenergic Receptor Activity Protein Binding Protein Kinase Binding Alpha-1B Adrenergic Receptor Binding Alpha-2C Adrenergic Receptor Binding Thioesterase Binding Heterotrimeric G-protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Epinephrine Binding Norepinephrine Binding	Actin Binding Protein Phosphatase Inhibitor Activity Protein Binding Protein Phosphatase 1 Binding
	Biological Process	Positive Regulation Of Cytokine Production Acute Inflammatory Response Energy Reserve Metabolic Process DNA Replication Movement Of Cell Or Subcellular Component Signal Transduction G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Ras Protein Signal Transduction Rho Protein Signal Transduction Female Pregnancy Blood Coagulation Positive Regulation Of Cell Proliferation Negative Regulation Of Norepinephrine Secretion Regulation Of Vasoconstriction Actin Cytoskeleton Organization Platelet Activation Positive Regulation Of Cell Migration Negative Regulation Of CAMP Biosynthetic Process Activation Of Protein Kinase Activity Activation Of Protein Kinase B Activity Negative Regulation Of Epinephrine Secretion Cellular Response To Hormone Stimulus Epidermal Growth Factor-activated Receptor Transactivation By G-protein Coupled Receptor Signaling Pathway Glucose Homeostasis Fear Response Positive Regulation Of Potassium Ion Transport Positive Regulation Of MAP Kinase Activity Small Molecule Metabolic Process Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Positive Regulation Of Vasodilation Negative Regulation Of Calcium Ion-dependent Exocytosis Negative Regulation Of Insulin Secretion Regulation Of Insulin Secretion Intestinal Absorption Thermoception Negative Regulation Of Lipid Catabolic Process Positive Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Calcium Ion Transport Negative Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Negative Regulation Of Uterine Smooth Muscle Contraction Negative Regulation Of Adrenergic Receptor Signaling Pathway Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway Phospholipase C-activating Adrenergic Receptor Signaling Pathway Activation Of MAPK Activity By Adrenergic Receptor Signaling Pathway Positive Regulation Of Wound Healing Negative Regulation Of Calcium Ion Transmembrane Transporter Activity	Regulation Of Cell Growth By Extracellular Stimulus Regulation Of Protein Phosphorylation Actin Filament Organization Cell Cycle Arrest Regulation Of Exit From Mitosis RNA Splicing Dendrite Development Cell Migration Calcium-mediated Signaling Negative Regulation Of Cell Growth Regulation Of Cell Proliferation Negative Regulation Of Catalytic Activity Filopodium Assembly Regulation Of Synaptic Transmission Cellular Response To Morphine Regulation Of Opioid Receptor Signaling Pathway
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Integration of energy metabolism Adrenaline signalling through Alpha-2 adrenergic receptor Class A/1 (Rhodopsin-like receptors) Regulation of insulin secretion Amine ligand-binding receptors Platelet Aggregation (Plug Formation) Metabolic disorders of biological oxidation enzymes GPCR ligand binding Adrenaline,noradrenaline inhibits insulin secretion GPCR downstream signaling Adrenoceptors G alpha (z) signalling events G alpha (i) signalling events Platelet activation, signaling and aggregation
Drugs		Bethanidine Ziprasidone Cabergoline Ropinirole Dihydroergotamine Amitriptyline Olanzapine Clozapine Norepinephrine Mirtazapine Phenylpropanolamine Pramipexole Dipivefrin Brimonidine Amoxapine Clonidine Lisuride Guanabenz Dexmedetomidine Trazodone Epinephrine Phentolamine Ergotamine Tizanidine Apomorphine Risperidone Epinastine Tolazoline Fenoldopam Pseudoephedrine Benzphetamine Phenoxybenzamine Oxymetazoline Apraclonidine Methyldopa Guanfacine Ergoloid mesylate Doxepin Nefazodone Pergolide Bromocriptine Quetiapine Aripiprazole Paliperidone Dihydroergotoxine Ephedra Yohimbine Methotrimeprazine 4-Methoxyamphetamine Methamphetamine Propericiazine Zuclopenthixol Dronedarone Lofexidine Mianserin Asenapine Droxidopa Xylometazoline Naphazoline Lurasidone
Diseases
GWAS		Fasting glucose-related traits ( 20081858) Fasting glucose-related traits (interaction with BMI) ( 22581228) Platelet aggregation ( 20526338)
Protein-Protein Interactions		13 interactors: ADRB1 ADRBK1 EIF2B1 GNAI1 GNAI2 GNAO1 GNB1 GNG2 PPP1R9B PRKCD SNTA1 UCHL1 YWHAZ	23 interactors: ACTA1 ADRA1A ADRA1B ADRA2A ADRA2B ADRA2C CCKAR CCKBR CDKN2A CHRM3 DCX DRD2 MAPK1 PPP1CA PPP1CB PPP1CC PPP1R2 PPP1R9A PRKACA RGS2 RPS6KB1 TGOLN2 TIAM1
Entrez ID		150	84687
HPRD ID		00078	04506
Ensembl ID		ENSG00000150594	ENSG00000108819
Uniprot IDs		P08913	D3DTX6 Q96SB3
PDB IDs		1HLL 1HO9 1HOD 1HOF
Enriched GO Terms of Interacting Partners?		Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Platelet Activation Regulation Of Body Fluid Levels Wound Healing Response To Wounding Response To Stress Blood Coagulation G-protein Coupled Acetylcholine Receptor Signaling Pathway Hemostasis Cell Activation Dopamine Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Regulation Of Heart Contraction Response To Organonitrogen Compound Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling Cell Communication Regulation Of Catalytic Activity Regulation Of The Force Of Heart Contraction By Chemical Signal Synaptic Transmission Response To Organic Substance Regulation Of Ion Transport Regulation Of Striated Muscle Contraction Cellular Response To Prostaglandin E Stimulus Response To Stimulus Regulation Of Signal Transduction Cell Proliferation Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Cellular Response To Stimulus Signal Transduction Cellular Response To Prostaglandin Stimulus Response To Prostaglandin E Energy Reserve Metabolic Process Regulation Of Signaling Cell Surface Receptor Signaling Pathway Negative Regulation Of Muscle Contraction Signaling Regulation Of Muscle Contraction Positive Regulation Of Catalytic Activity Response To Peptide Hormone Cellular Response To Catecholamine Stimulus Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Response To Peptide Regulation Of The Force Of Heart Contraction Regulation Of Cellular Process Regulation Of Calcium Ion Transport Positive Regulation Of Hydrolase Activity Response To Morphine Cellular Response To Glucagon Stimulus	Energy Reserve Metabolic Process Adrenergic Receptor Signaling Pathway Regulation Of Signaling Regulation Of Muscle Contraction Regulation Of Smooth Muscle Contraction Regulation Of Vasoconstriction Regulation Of Signal Transduction Energy Derivation By Oxidation Of Organic Compounds Signal Transduction Cell Surface Receptor Signaling Pathway Activation Of MAPK Activity By Adrenergic Receptor Signaling Pathway Signaling Cellular Response To Stimulus Regulation Of Phosphorus Metabolic Process Cell Communication Negative Regulation Of Signaling Regulation Of MAPK Cascade Generation Of Precursor Metabolites And Energy Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Epidermal Growth Factor-activated Receptor Transactivation By G-protein Coupled Receptor Signaling Pathway Regulation Of Hormone Secretion Triglyceride Catabolic Process Positive Regulation Of MAPK Cascade Regulation Of Phosphorylation Receptor Transactivation Acylglycerol Catabolic Process Developmental Process Negative Regulation Of Epinephrine Secretion Response To External Stimulus Regulation Of Kinase Activity Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Glycogen Catabolic Process G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Norepinephrine Secretion Response To Organic Substance Response To Stimulus Positive Regulation Of Signal Transduction Muscle System Process Regulation Of Intracellular Signal Transduction Activation Of Protein Kinase Activity Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Regulation Of Cellular Localization Regulation Of Protein Kinase Activity Regulation Of MAP Kinase Activity System Development Anatomical Structure Development Regulation Of Norepinephrine Secretion Negative Regulation Of Signal Transduction Response To Abiotic Stimulus
Tagcloud ?		adrenergic arg347cys bk2r check chronotropic dbp enos exercise glu298asp melting neurohumoral nitric overt paulo polymorphisms programme reserve rs1048101 rs1799983 rs2070744 rs28365031 rs553668 rs5810761 sao sbp synthase treadmill	accn1 ago arises cgg description disturbed eef1a2 fmr1 fmrp fragile gabrd hes1 inherited intelligence interactive lending lymphoblastoid lymphoblasts males microarrays morphogenesis neurodevelopment overrepresentation retardation syndrome transcriptome trinucleotide unc13b untranslated
Tagcloud (Difference) ?		adrenergic arg347cys bk2r check chronotropic dbp enos exercise glu298asp melting neurohumoral nitric overt paulo polymorphisms programme reserve rs1048101 rs1799983 rs2070744 rs28365031 rs553668 rs5810761 sao sbp synthase treadmill	accn1 ago arises cgg description disturbed eef1a2 fmr1 fmrp fragile gabrd hes1 inherited intelligence interactive lending lymphoblastoid lymphoblasts males microarrays morphogenesis neurodevelopment overrepresentation retardation syndrome transcriptome trinucleotide unc13b untranslated
Tagcloud (Intersection) ?