TICAM1 and TRAF4

Number of citations of the paper that reports this interaction (PubMedID 16052631)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		TICAM1	TRAF4
Description		TIR domain containing adaptor molecule 1	TNF receptor associated factor 4
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Endosome Early Endosome Autophagosome Cytosol Endosome Membrane Cytoplasmic Vesicle Ripoptosome	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Bicellular Tight Junction Membrane Perinuclear Region Of Cytoplasm Anchoring Junction
	Molecular Function	Protein Binding Protein Kinase Binding Signaling Adaptor Activity Molecular Adaptor Activity	Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Transferase Activity Enzyme Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Thioesterase Binding Signaling Adaptor Activity Identical Protein Binding Metal Ion Binding WW Domain Binding
	Biological Process	Toll-like Receptor Signaling Pathway Macrophage Activation Involved In Immune Response Immune System Process Positive Regulation Of Myeloid Dendritic Cell Cytokine Production MyD88-independent Toll-like Receptor Signaling Pathway Nitric Oxide Biosynthetic Process Apoptotic Process Inflammatory Response Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Autophagy Positive Regulation Of Gene Expression Positive Regulation Of B Cell Proliferation Positive Regulation Of Protein Ubiquitination Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Type I Interferon Production Response To Lipopolysaccharide Positive Regulation Of Chemokine Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Natural Killer Cell Activation Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway B Cell Proliferation B Cell Activation Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Protein-containing Complex Assembly Response To Exogenous DsRNA Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of B Cell Activation Defense Response To Virus Positive Regulation Of Macrophage Cytokine Production Cellular Response To Lipopolysaccharide Apoptotic Signaling Pathway Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus Positive Regulation Of Cytokine Production Involved In Inflammatory Response	Immune System Process Apoptotic Process Signal Transduction Cell Surface Receptor Signaling Pathway Respiratory Gaseous Exchange By Respiratory System Respiratory Tube Development Regulation Of Apoptotic Process Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Positive Regulation Of Protein Kinase Activity Positive Regulation Of JNK Cascade
Pathways		Caspase activation via Death Receptors in the presence of ligand MyD88-independent TLR4 cascade Toll Like Receptor 3 (TLR3) Cascade TICAM1, RIP1-mediated IKK complex recruitment RIP-mediated NFkB activation via ZBP1 TRIF-mediated programmed cell death TICAM1 deficiency - HSE TRAF3 deficiency - HSE TLR3-mediated TICAM1-dependent programmed cell death TICAM1-dependent activation of IRF3/IRF7 TICAM1,TRAF6-dependent induction of TAK1 complex Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) IKK complex recruitment mediated by RIP1 TRAF6-mediated induction of TAK1 complex within TLR4 complex IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation
Drugs
Diseases
GWAS		Basal cell carcinoma ( 33549134) Medication use (thyroid preparations) ( 31015401) Vitiligo ( 22561518 27723757)
Interacting Genes		25 interacting genes: AZI2 IKBKE IRF3 IRF7 MAVS PIAS4 PIK3CA RIPK1 RIPK3 SRSF4 TBK1 TICAM2 TIRAP TLR2 TLR3 TNFAIP3 TRAF1 TRAF2 TRAF3 TRAF4 TRAF6 TRAM1 TRIM8 UBQLN1 WWP2	137 interacting genes: ABI3 ACTMAP ALKBH4 ANXA1 AR ATOSB ATOX1 BACH2 BAHD1 BANP BCKDK BCL6B BEGAIN BEX3 BYSL CALCOCO2 CAV1 CBL CBLC CCHCR1 CENPE CEP85 CHEK1 CHUK DISC1 DNM2 DPEP2NB DTX3 EXOC7 EYA2 EZHIP FAM90A1 FAT1 FBXL18 FRS3 FTH1 GOLGA2 GOLGA6A GOLGA6L9 GORASP1 GORASP2 GPRASP1 HEY2 HGS HMG20A HOMEZ HOXA1 HOXB5 IRAK1 IRS1 ISYNA1 KANK2 KANSL1 KDM1A KRT31 KRT36 LENG8 LNX1 LTBR MAGEC2 MAGED1 MAP3K4 MRPL28 NCF1 NGFR NHERF2 NOS1AP NPAS2 NTRK1 NUDT16L1 OGT PCSK5 PDE4DIP PHLDA1 PICK1 PKD1P1 PLAGL2 PLEKHA7 PLSCR1 POLR2J POLR2J3 PSMC3 QARS1 RAD54L2 RBPMS REXO1L6P RNF114 RNF144B RNF4 RPS6KB1 SF3B4 SIGLEC7 SMURF1 SMURF2 SNRPB SORBS2 SPDL1 SUMO1 TARBP2 TAX1BP1 TBC1D7 TBC1D8 TFAP4 TGFB1I1 TICAM1 TNFRSF4 TP53BP2 TRAF6 TRIM27 TRIM37 TSGA10IP TYK2 UBC UBE2D1 UBE2I UBL4A UBL4B USP7 VPS52 WBP11 WWP1 WWP2 ZBTB16 ZBTB26 ZC3H12C ZMYM5 ZNF177 ZNF275 ZNF3 ZNF512B ZNF559-ZNF177 ZNF581 ZNF620 ZNF688 ZNF784 ZNF835 ZRANB1
Entrez ID		148022	9618
HPRD ID		06350	03915
Ensembl ID		ENSG00000127666	ENSG00000076604
Uniprot IDs		Q8IUC6	Q9BUZ4
PDB IDs		2M1X 2M63 3RC4 4BSX 4C0M 5JEL 9DK8	2EOD 2YUC 3ZJB 4K8U 4M4E 5YC1
Enriched GO Terms of Interacting Partners?		Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Activation Of Innate Immune Response Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Intracellular Signal Transduction Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Innate Immune Response-activating Signaling Pathway Regulation Of Signal Transduction Signaling Adaptor Activity Defense Response To Virus Defense Response Positive Regulation Of Innate Immune Response Activation Of Immune Response Regulation Of Innate Immune Response Regulation Of Immune Response Positive Regulation Of Defense Response Regulation Of Interferon-beta Production Regulation Of Cell Communication Regulation Of Signaling Immune Response-activating Signaling Pathway Positive Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Cytokine Production Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Immune Response Positive Regulation Of Cytokine Production Response To External Biotic Stimulus Positive Regulation Of Signal Transduction Response To Virus Response To Stress Response To Other Organism Immune Response-regulating Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Cell Surface Toll-like Receptor Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Toll-like Receptor Signaling Pathway Positive Regulation Of Immune System Process Type I Interferon-mediated Signaling Pathway Innate Immune Response Regulation Of Defense Response Cell Surface Pattern Recognition Receptor Signaling Pathway Immune System Process Regulation Of Immune System Process Cell Surface Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Defense Response To Symbiont Interferon-mediated Signaling Pathway Identical Protein Binding	Protein Binding Nucleus Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Protein Modification Process Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Cytosol Protein Modification By Small Protein Conjugation Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein Ubiquitination Regulation Of Transcription By RNA Polymerase II Ubiquitin-protein Transferase Activity Regulation Of Gene Expression Ubiquitin Protein Ligase Activity Post-translational Protein Modification Negative Regulation Of RNA Metabolic Process Modification-dependent Protein Catabolic Process Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cell Surface Toll-like Receptor Signaling Pathway Identical Protein Binding Ubiquitin-dependent Protein Catabolic Process Protein Metabolic Process Cell Surface Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Proteolysis Involved In Protein Catabolic Process Cytoplasm Positive Regulation Of Metabolic Process Regulation Of Protein Modification Process Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Ubiquitination Regulation Of Post-translational Protein Modification Regulation Of Protein Ubiquitination PML Body Regulation Of Programmed Cell Death Negative Regulation Of Macromolecule Biosynthetic Process Signaling Adaptor Activity Zinc Ion Binding Proteolysis Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Macromolecule Catabolic Process Positive Regulation Of Protein Metabolic Process
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