TICAM1 and SRSF4

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		TICAM1	SRSF4
Gene Name		toll-like receptor adaptor molecule 1	serine/arginine-rich splicing factor 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Endosome Membrane Ripoptosome	Nucleus Nucleoplasm Nuclear Speck
	Molecular Function	Signal Transducer Activity Protein Binding Protein Kinase Binding	Nucleotide Binding Poly(A) RNA Binding
	Biological Process	Toll-like Receptor Signaling Pathway Macrophage Activation Involved In Immune Response MyD88-independent Toll-like Receptor Signaling Pathway Inflammatory Response I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of B Cell Proliferation Positive Regulation Of Protein Ubiquitination Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Protein Binding Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Natural Killer Cell Activation Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Exogenous DsRNA Regulation Of Protein Homodimerization Activity Positive Regulation Of Chemokine Biosynthetic Process Innate Immune Response Positive Regulation Of Interferon-beta Biosynthetic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Apoptotic Signaling Pathway	RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome Hematopoietic Progenitor Cell Differentiation Transcription From RNA Polymerase II Promoter Termination Of RNA Polymerase II Transcription MRNA Processing MRNA Export From Nucleus RNA Splicing Gene Expression MRNA 3'-end Processing Negative Regulation Of MRNA Splicing, Via Spliceosome
Pathways		TRAF6 mediated induction of TAK1 complex TRIF-mediated TLR3/TLR4 signaling IKK complex recruitment mediated by RIP1 Cytosolic sensors of pathogen-associated DNA MyD88-independent cascade RIP-mediated NFkB activation via ZBP1 Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon Activated TLR4 signalling Toll-Like Receptors Cascades ZBP1(DAI) mediated induction of type I IFNs Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade TRIF-mediated programmed cell death Innate Immune System	mRNA Splicing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway Transport of Mature Transcript to Cytoplasm Cleavage of Growing Transcript in the Termination Region RNA Polymerase II Transcription Termination mRNA 3'-end processing
Drugs
Diseases
GWAS		Vitiligo ( 22561518)
Protein-Protein Interactions		23 interactors: AZI2 IKBKE IRF3 IRF7 MAVS PIAS4 PIK3CA RIPK1 RIPK3 SRSF4 TBK1 TICAM2 TIRAP TLR2 TLR3 TNFAIP3 TRAF1 TRAF2 TRAF3 TRAF4 TRAF6 TRAM1 UBQLN1	23 interactors: DYRK1A FUS GEMIN2 HAP1 HTATSF1 PNN PPARGC1A PRPF38A RNPS1 SART1 SCAF11 SMURF1 SMURF2 SREK1 SRPK1 SRRM2 SRSF1 SRSF10 SRSF2 SRSF6 TICAM1 TRA2B ZDHHC17
Entrez ID		148022	6429
HPRD ID		06350	09052
Ensembl ID		ENSG00000127666	ENSG00000116350
Uniprot IDs		Q8IUC6	Q08170
PDB IDs		3RC4
Enriched GO Terms of Interacting Partners?		Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway Regulation Of Innate Immune Response Regulation Of Type I Interferon Production TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Immune Response-regulating Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Immune Response Regulation Of Cytokine Production Innate Immune Response Regulation Of Immune Response Regulation Of Interferon-beta Production Positive Regulation Of Immune System Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cytokine Production Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Immune System Process Immune Response Positive Regulation Of Intracellular Signal Transduction Defense Response Positive Regulation Of Type I Interferon Production Immune System Process Intracellular Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Interferon-beta Production Regulation Of Signaling Regulation Of Intracellular Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity NIK/NF-kappaB Signaling Regulation Of Toll-like Receptor Signaling Pathway Negative Regulation Of Type I Interferon Production Signal Transduction Regulation Of Protein Metabolic Process Positive Regulation Of Interferon-alpha Production Negative Regulation Of Cytokine Production Cellular Response To Stimulus Positive Regulation Of Protein Metabolic Process Signaling Cell Communication Apoptotic Process Programmed Cell Death	RNA Splicing MRNA Processing MRNA Metabolic Process RNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Gene Expression Regulation Of MRNA Processing Regulation Of RNA Splicing Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nuclear Export Nitrogen Compound Metabolic Process Spliceosomal Complex Assembly MRNA Export From Nucleus RNA Export From Nucleus Regulation Of Alternative MRNA Splicing, Via Spliceosome Ribonucleoprotein Complex Assembly Termination Of RNA Polymerase II Transcription MRNA Transport Cellular Metabolic Process Nucleocytoplasmic Transport Nuclear Transport RNA Transport RNA Localization Ribonucleoprotein Complex Biogenesis Negative Regulation Of MRNA Splicing, Via Spliceosome DNA-templated Transcription, Termination Negative Regulation Of RNA Splicing MRNA 3'-end Processing Regulation Of RNA Metabolic Process RNA 3'-end Processing Regulation Of Nitrogen Compound Metabolic Process Spliceosomal SnRNP Assembly MRNA Splice Site Selection Ubiquitin-dependent SMAD Protein Catabolic Process Cellular Macromolecular Complex Assembly Regulation Of Gene Expression Cytoplasmic Transport Metabolic Process MRNA Cis Splicing, Via Spliceosome Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Intracellular Transport Regulation Of Metabolic Process
Tagcloud ?		alters annotation ca3 candidate cdh23 dataset disequilibrium ear fdr filtering gwas harbored hist3h3 hypotheses hypothetical icsnpathway il27ra innate modulates morphogenesis pneumoconiosis ptprz1 rs11592462 rs2230656 rs2292151 rs8120 snps stereocilia strongest	abundant altering changed clk decay deep detained detention dis dramatic evolutionarily half hour intron introns lives mdm4 nmd nonsense polyadenylated pools shift splicing subject thousands transcript triggered undergoes widespread
Tagcloud (Difference) ?		alters annotation ca3 candidate cdh23 dataset disequilibrium ear fdr filtering gwas harbored hist3h3 hypotheses hypothetical icsnpathway il27ra innate modulates morphogenesis pneumoconiosis ptprz1 rs11592462 rs2230656 rs2292151 rs8120 snps stereocilia strongest	abundant altering changed clk decay deep detained detention dis dramatic evolutionarily half hour intron introns lives mdm4 nmd nonsense polyadenylated pools shift splicing subject thousands transcript triggered undergoes widespread
Tagcloud (Intersection) ?