TICAM1 and TRAM1

Number of citations of the paper that reports this interaction (PubMedID 12721283)
0

Data Source:
HPRD (in vivo)

		TICAM1	TRAM1
Description		TIR domain containing adaptor molecule 1	translocation associated membrane protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Endosome Early Endosome Autophagosome Cytosol Endosome Membrane Cytoplasmic Vesicle Ripoptosome	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Protein Binding Protein Kinase Binding Signaling Adaptor Activity Molecular Adaptor Activity	Protein Binding Signaling Receptor Activity
	Biological Process	Toll-like Receptor Signaling Pathway Macrophage Activation Involved In Immune Response Immune System Process Positive Regulation Of Myeloid Dendritic Cell Cytokine Production MyD88-independent Toll-like Receptor Signaling Pathway Nitric Oxide Biosynthetic Process Apoptotic Process Inflammatory Response Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Autophagy Positive Regulation Of Gene Expression Positive Regulation Of B Cell Proliferation Positive Regulation Of Protein Ubiquitination Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Type I Interferon Production Response To Lipopolysaccharide Positive Regulation Of Chemokine Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Natural Killer Cell Activation Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway B Cell Proliferation B Cell Activation Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Protein-containing Complex Assembly Response To Exogenous DsRNA Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of B Cell Activation Defense Response To Virus Positive Regulation Of Macrophage Cytokine Production Cellular Response To Lipopolysaccharide Apoptotic Signaling Pathway Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus Positive Regulation Of Cytokine Production Involved In Inflammatory Response	Cotranslational Protein Targeting To Membrane SRP-dependent Cotranslational Protein Targeting To Membrane, Translocation Response To Unfolded Protein Protein Transport Protein Insertion Into ER Membrane
Pathways		Caspase activation via Death Receptors in the presence of ligand MyD88-independent TLR4 cascade Toll Like Receptor 3 (TLR3) Cascade TICAM1, RIP1-mediated IKK complex recruitment RIP-mediated NFkB activation via ZBP1 TRIF-mediated programmed cell death TICAM1 deficiency - HSE TRAF3 deficiency - HSE TLR3-mediated TICAM1-dependent programmed cell death TICAM1-dependent activation of IRF3/IRF7 TICAM1,TRAF6-dependent induction of TAK1 complex Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) IKK complex recruitment mediated by RIP1 TRAF6-mediated induction of TAK1 complex within TLR4 complex IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	SRP-dependent cotranslational protein targeting to membrane
Drugs
Diseases
GWAS		Basal cell carcinoma ( 33549134) Medication use (thyroid preparations) ( 31015401) Vitiligo ( 22561518 27723757)	Cardiac Troponin-T levels ( 23247143) Erythrocyte cadmium concentration in never smokers ( 27005419) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		25 interacting genes: AZI2 IKBKE IRF3 IRF7 MAVS PIAS4 PIK3CA RIPK1 RIPK3 SRSF4 TBK1 TICAM2 TIRAP TLR2 TLR3 TNFAIP3 TRAF1 TRAF2 TRAF3 TRAF4 TRAF6 TRAM1 TRIM8 UBQLN1 WWP2	12 interacting genes: APP CREB3 DRD2 ESR1 ESR2 GUCA2A SEC61B TICAM1 TIRAP TRAF6 UBC VKORC1
Entrez ID		148022	23471
HPRD ID		06350	05545
Ensembl ID		ENSG00000127666	ENSG00000067167
Uniprot IDs		Q8IUC6	G3XAN4 Q15629 Q6FHL3
PDB IDs		2M1X 2M63 3RC4 4BSX 4C0M 5JEL 9DK8
Enriched GO Terms of Interacting Partners?		Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Activation Of Innate Immune Response Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Intracellular Signal Transduction Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Innate Immune Response-activating Signaling Pathway Regulation Of Signal Transduction Signaling Adaptor Activity Defense Response To Virus Defense Response Positive Regulation Of Innate Immune Response Activation Of Immune Response Regulation Of Innate Immune Response Regulation Of Immune Response Positive Regulation Of Defense Response Regulation Of Interferon-beta Production Regulation Of Cell Communication Regulation Of Signaling Immune Response-activating Signaling Pathway Positive Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Cytokine Production Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Immune Response Positive Regulation Of Cytokine Production Response To External Biotic Stimulus Positive Regulation Of Signal Transduction Response To Virus Response To Stress Response To Other Organism Immune Response-regulating Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Cell Surface Toll-like Receptor Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Toll-like Receptor Signaling Pathway Positive Regulation Of Immune System Process Type I Interferon-mediated Signaling Pathway Innate Immune Response Regulation Of Defense Response Cell Surface Pattern Recognition Receptor Signaling Pathway Immune System Process Regulation Of Immune System Process Cell Surface Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Defense Response To Symbiont Interferon-mediated Signaling Pathway Identical Protein Binding	Positive Regulation Of Interleukin-6 Production Regulation Of Innate Immune Response Cellular Response To Oxygen-containing Compound Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Interleukin-6 Production Positive Regulation Of Nitric Oxide Metabolic Process Nuclear Estrogen Receptor Activity Toll-like Receptor 4 Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway Toll-like Receptor Signaling Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Lipid Response To Lipid Regulation Of Defense Response Positive Regulation Of Chemokine Production Positive Regulation Of Biosynthetic Process Intracellular Receptor Signaling Pathway Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cytokine Production Signaling Adaptor Activity Estrogen Response Element Binding TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Immune Response Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Positive Regulation Of Leukocyte Chemotaxis MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Chemokine Production Positive Regulation Of JNK Cascade Regulation Of Immune System Process MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cell Population Proliferation Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Response To Estradiol Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Neurotransmitter Uptake Myeloid Leukocyte Activation Regulation Of Type I Interferon Production Nuclear Steroid Receptor Activity Intracellular Signal Transduction Positive Regulation Of Long-term Synaptic Potentiation
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