TICAM1 and UBQLN1

Number of citations of the paper that reports this interaction (PMID 21695056)
6

Data Source:
BioGRID (affinity chromatography technology, pull down)

		TICAM1	UBQLN1
Gene Name		toll-like receptor adaptor molecule 1	ubiquilin 1
Image
Gene Ontology Annotations	Cellular Component	Cytosol Endosome Membrane Ripoptosome	Proteasome Complex Nucleoplasm Cytoplasm Endoplasmic Reticulum Protein Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Signal Transducer Activity Protein Binding Protein Kinase Binding	Protein Binding Kinase Binding Protein Domain Specific Binding
	Biological Process	Toll-like Receptor Signaling Pathway Macrophage Activation Involved In Immune Response MyD88-independent Toll-like Receptor Signaling Pathway Inflammatory Response I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of B Cell Proliferation Positive Regulation Of Protein Ubiquitination Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Protein Binding Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Natural Killer Cell Activation Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Exogenous DsRNA Regulation Of Protein Homodimerization Activity Positive Regulation Of Chemokine Biosynthetic Process Innate Immune Response Positive Regulation Of Interferon-beta Biosynthetic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Apoptotic Signaling Pathway	Regulation Of Protein Ubiquitination Response To Endoplasmic Reticulum Stress Cellular Response To Hypoxia Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Pathways		TRAF6 mediated induction of TAK1 complex TRIF-mediated TLR3/TLR4 signaling IKK complex recruitment mediated by RIP1 Cytosolic sensors of pathogen-associated DNA MyD88-independent cascade RIP-mediated NFkB activation via ZBP1 Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon Activated TLR4 signalling Toll-Like Receptors Cascades ZBP1(DAI) mediated induction of type I IFNs Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade TRIF-mediated programmed cell death Innate Immune System
Drugs
Diseases
GWAS		Vitiligo ( 22561518)
Protein-Protein Interactions		23 interactors: AZI2 IKBKE IRF3 IRF7 MAVS PIAS4 PIK3CA RIPK1 RIPK3 SRSF4 TBK1 TICAM2 TIRAP TLR2 TLR3 TNFAIP3 TRAF1 TRAF2 TRAF3 TRAF4 TRAF6 TRAM1 UBQLN1	151 interactors: ABCC2 ACOT7 ADRM1 AGPAT5 AGR2 AGR3 APP ASCL1 ATXN3 BPIFA1 C1QA C1QTNF2 CALU CARKD CCL7 CCNB1 CD47 CD99 CD99L2 CHGB CHRNA3 CHRNA4 CHRNB4 COL10A1 COL1A2 COLGALT2 COMTD1 CSTF2 CSTF2T CTAG1B CTAG2 CYB5R1 DEFA6 DNAJB2 EFEMP2 EP300 EPS15 ERP27 ETNK1 F8 FAM127A FAM127B FAM127C FAM189A2 FAM86B3P FAS FBXO25 FCGR2A FGF7 FKBP2 FN1 FZD7 GABRA1 GABRA2 GABRA3 GABRA6 GABRB1 GABRB2 GABRB3 GABRD GHRL GIT2 GKAP1 GPX3 GRM2 GYPB HERC3 HES1 HGS HK2 HSD17B12 HSPA13 IGL IGLC1 IGLV2-14 IL6ST IST1 ITPRIPL1 KLHL42 LITAF MANBAL MCM7 MIEF1 MIEF2 MLLT6 MTOR NBL1 NDE1 NGLY1 NME3 NPPA NPY NUPL1 P4HB PBXIP1 PIK3IP1 PLA2G16 PNMA1 PPIB PPIC PRAP1 PRB1 PRPF40A PSEN1 PSEN2 PSMD4 PSMD6 PTN RARA RASSF5 RIC8A RNF208 RPN1 RSRC2 SCG5 SCMH1 SERPINE1 SERPINI2 SIL1 SLC29A2 SMAD9 SMIM2 SMR3B SPARC SRGN STMN3 TARDBP TFF1 TICAM1 TMCO6 TMEM31 TMEM37 TMUB2 TNFRSF1A TNFRSF1B TREX1 TRIM32 TXNDC12 UBB UBC UBE2V1 UBQLN4 UBXN1 UBXN4 VCP XPO4 ZFAND2B ZG16 ZG16B ZMYM4 ZNF343
Entrez ID		148022	29979
HPRD ID		06350	05440
Ensembl ID		ENSG00000127666	ENSG00000135018
Uniprot IDs		Q8IUC6	Q9UMX0
PDB IDs		3RC4	2JY5 2JY6 2KLC
Enriched GO Terms of Interacting Partners?		Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway Regulation Of Innate Immune Response Regulation Of Type I Interferon Production TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Immune Response-regulating Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Immune Response Regulation Of Cytokine Production Innate Immune Response Regulation Of Immune Response Regulation Of Interferon-beta Production Positive Regulation Of Immune System Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cytokine Production Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Immune System Process Immune Response Positive Regulation Of Intracellular Signal Transduction Defense Response Positive Regulation Of Type I Interferon Production Immune System Process Intracellular Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Interferon-beta Production Regulation Of Signaling Regulation Of Intracellular Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity NIK/NF-kappaB Signaling Regulation Of Toll-like Receptor Signaling Pathway Negative Regulation Of Type I Interferon Production Signal Transduction Regulation Of Protein Metabolic Process Positive Regulation Of Interferon-alpha Production Negative Regulation Of Cytokine Production Cellular Response To Stimulus Positive Regulation Of Protein Metabolic Process Signaling Cell Communication Apoptotic Process Programmed Cell Death	Response To Stress Response To Organic Substance Positive Regulation Of Proteolysis Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Proteolysis Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Extracellular Matrix Organization Extracellular Structure Organization Response To Stimulus Regulation Of Protein Metabolic Process Cellular Response To Histamine Cellular Response To Organic Substance Cell-cell Signaling Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Synaptic Transmission Platelet Degranulation Signal Transduction Regulation Of Protein Ubiquitination Regulation Of Protein Catabolic Process Regulation Of ERBB Signaling Pathway Response To Histamine Chloride Transmembrane Transport Response To Organic Cyclic Compound Positive Regulation Of Protein Catabolic Process Signaling Cell Surface Receptor Signaling Pathway Response To Abiotic Stimulus Gamma-aminobutyric Acid Signaling Pathway Response To Hypoxia Cell Communication Chloride Transport Notch Signaling Pathway Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Immune System Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Modification Process Positive Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Cellular Response To Oxygen Levels Regulation Of Cellular Process Defense Response Positive Regulation Of Cell Cycle Cellular Response To Ammonium Ion Notch Receptor Processing Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Tagcloud ?		alters annotation ca3 candidate cdh23 dataset disequilibrium ear fdr filtering gwas harbored hist3h3 hypotheses hypothetical icsnpathway il27ra innate modulates morphogenesis pneumoconiosis ptprz1 rs11592462 rs2230656 rs2292151 rs8120 snps stereocilia strongest	affecting aid biomarkers biosynthesis contamination differentially elucidated evaluating exert exposed hepatic hepatotoxicity hnrnpc huwe1 itraq labeling ontology paf1 perfluorinated perfluorooctane pfos proteomic splicing sulfonate technology toxic transduction trigger whose
Tagcloud (Difference) ?		alters annotation ca3 candidate cdh23 dataset disequilibrium ear fdr filtering gwas harbored hist3h3 hypotheses hypothetical icsnpathway il27ra innate modulates morphogenesis pneumoconiosis ptprz1 rs11592462 rs2230656 rs2292151 rs8120 snps stereocilia strongest	affecting aid biomarkers biosynthesis contamination differentially elucidated evaluating exert exposed hepatic hepatotoxicity hnrnpc huwe1 itraq labeling ontology paf1 perfluorinated perfluorooctane pfos proteomic splicing sulfonate technology toxic transduction trigger whose
Tagcloud (Intersection) ?