TICAM1 and IRF3

Number of citations of the paper that reports this interaction (PubMedID 14739303)
0

Data Source:
HPRD (two hybrid, in vivo)

		TICAM1	IRF3
Description		TIR domain containing adaptor molecule 1	interferon regulatory factor 3
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Endosome Early Endosome Autophagosome Cytosol Endosome Membrane Cytoplasmic Vesicle Ripoptosome	Chromatin Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol
	Molecular Function	Protein Binding Protein Kinase Binding Signaling Adaptor Activity Molecular Adaptor Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding Identical Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding
	Biological Process	Toll-like Receptor Signaling Pathway Macrophage Activation Involved In Immune Response Immune System Process Positive Regulation Of Myeloid Dendritic Cell Cytokine Production MyD88-independent Toll-like Receptor Signaling Pathway Nitric Oxide Biosynthetic Process Apoptotic Process Inflammatory Response Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Autophagy Positive Regulation Of Gene Expression Positive Regulation Of B Cell Proliferation Positive Regulation Of Protein Ubiquitination Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Type I Interferon Production Response To Lipopolysaccharide Positive Regulation Of Chemokine Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Natural Killer Cell Activation Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway B Cell Proliferation B Cell Activation Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Protein-containing Complex Assembly Response To Exogenous DsRNA Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of B Cell Activation Defense Response To Virus Positive Regulation Of Macrophage Cytokine Production Cellular Response To Lipopolysaccharide Apoptotic Signaling Pathway Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus Positive Regulation Of Cytokine Production Involved In Inflammatory Response	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cytokine Production Immune System Process Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Apoptotic Process DNA Damage Response Cell Surface Receptor Signaling Pathway MRNA Transcription Response To Bacterium Regulation Of Gene Expression Programmed Cell Death Signal Transduction Involved In Regulation Of Gene Expression Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Type I Interferon Production Response To Lipopolysaccharide Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MDA-5 Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Response To Exogenous DsRNA Innate Immune Response Positive Regulation Of Innate Immune Response Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Inflammatory Response Defense Response To Virus Type I Interferon-mediated Signaling Pathway Positive Regulation Of Type I Interferon-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Exogenous DsRNA Macrophage Apoptotic Process Programmed Necrotic Cell Death Cellular Response To Virus Antiviral Innate Immune Response CGAS/STING Signaling Pathway Positive Regulation Of Cytokine Production Involved In Inflammatory Response
Pathways		Caspase activation via Death Receptors in the presence of ligand MyD88-independent TLR4 cascade Toll Like Receptor 3 (TLR3) Cascade TICAM1, RIP1-mediated IKK complex recruitment RIP-mediated NFkB activation via ZBP1 TRIF-mediated programmed cell death TICAM1 deficiency - HSE TRAF3 deficiency - HSE TLR3-mediated TICAM1-dependent programmed cell death TICAM1-dependent activation of IRF3/IRF7 TICAM1,TRAF6-dependent induction of TAK1 complex Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) IKK complex recruitment mediated by RIP1 TRAF6-mediated induction of TAK1 complex within TLR4 complex IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	ISG15 antiviral mechanism IRF3 mediated activation of type 1 IFN IRF3 mediated activation of type 1 IFN DDX58/IFIH1-mediated induction of interferon-alpha/beta LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production Regulation of innate immune responses to cytosolic DNA IRF3-mediated induction of type I IFN Interferon gamma signaling TICAM1-dependent activation of IRF3/IRF7 Interferon alpha/beta signaling TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation Negative regulators of DDX58/IFIH1 signaling Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses Evasion by RSV of host interferon responses
Drugs
Diseases
GWAS		Basal cell carcinoma ( 33549134) Medication use (thyroid preparations) ( 31015401) Vitiligo ( 22561518 27723757)	Autoimmune thyroid disease ( 32581359) Schizophrenia ( 29483656) Vitiligo ( 27723757)
Interacting Genes		25 interacting genes: AZI2 IKBKE IRF3 IRF7 MAVS PIAS4 PIK3CA RIPK1 RIPK3 SRSF4 TBK1 TICAM2 TIRAP TLR2 TLR3 TNFAIP3 TRAF1 TRAF2 TRAF3 TRAF4 TRAF6 TRAM1 TRIM8 UBQLN1 WWP2	35 interacting genes: CREBBP EP300 EWSR1 FBXO7 GRIP1 HERC5 HSP90AA1 IKBKE ILF3 IRF5 IRF7 JMJD6 MAPK8 MAVS OGT PEX19 PIAS4 PPIB PRDX1 PSMD14 RB1 RBL1 RELA SERPINB2 SGTA SMURF2 SYT1 TBK1 TICAM1 TICAM2 TOMM70 TRIM26 TRIM55 TRIM63 UFL1
Entrez ID		148022	3661
HPRD ID		06350	04769
Ensembl ID		ENSG00000127666	ENSG00000126456
Uniprot IDs		Q8IUC6	E2GIM5 E2GIM6 E2GIM7 E2GIM8 E2GIM9 M0QYT9 Q14653 Q96GL3
PDB IDs		2M1X 2M63 3RC4 4BSX 4C0M 5JEL 9DK8	1J2F 1QWT 1T2K 1ZOQ 2O61 2O6G 2PI0 3A77 3QU6 5JEJ 5JEK 5JEL 5JEM 5JEO 5JER 6SIV 6SJA 7JFL
Enriched GO Terms of Interacting Partners?		Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Activation Of Innate Immune Response Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Intracellular Signal Transduction Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Innate Immune Response-activating Signaling Pathway Regulation Of Signal Transduction Signaling Adaptor Activity Defense Response To Virus Defense Response Positive Regulation Of Innate Immune Response Activation Of Immune Response Regulation Of Innate Immune Response Regulation Of Immune Response Positive Regulation Of Defense Response Regulation Of Interferon-beta Production Regulation Of Cell Communication Regulation Of Signaling Immune Response-activating Signaling Pathway Positive Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Cytokine Production Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Immune Response Positive Regulation Of Cytokine Production Response To External Biotic Stimulus Positive Regulation Of Signal Transduction Response To Virus Response To Stress Response To Other Organism Immune Response-regulating Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Cell Surface Toll-like Receptor Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Toll-like Receptor Signaling Pathway Positive Regulation Of Immune System Process Type I Interferon-mediated Signaling Pathway Innate Immune Response Regulation Of Defense Response Cell Surface Pattern Recognition Receptor Signaling Pathway Immune System Process Regulation Of Immune System Process Cell Surface Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Defense Response To Symbiont Interferon-mediated Signaling Pathway Identical Protein Binding	Activation Of Innate Immune Response Positive Regulation Of Type I Interferon Production Defense Response To Virus Response To Virus Positive Regulation Of Innate Immune Response Positive Regulation Of Interferon-beta Production Immune System Process Regulation Of Type I Interferon Production Response To Other Organism Response To External Biotic Stimulus Innate Immune Response Defense Response Activation Of Immune Response Regulation Of Defense Response Canonical NF-kappaB Signal Transduction Regulation Of Interferon-beta Production Regulation Of Innate Immune Response Positive Regulation Of Defense Response Innate Immune Response-activating Signaling Pathway Defense Response To Symbiont Response To Stress Defense Response To Other Organism Positive Regulation Of Immune Response Intracellular Signal Transduction Regulation Of Immune Response Immune Response Positive Regulation Of Immune System Process Cytoplasm Immune Response-regulating Signaling Pathway Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Regulation Of Metabolic Process Regulation Of Immune System Process Protein Modification Process Regulation Of Primary Metabolic Process Immune Response-activating Signaling Pathway Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation Of Multicellular Organismal Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cytokine Production Positive Regulation Of Type I Interferon-mediated Signaling Pathway Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Protein-containing Complex Assembly Positive Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Interferon-alpha Production Positive Regulation Of Response To Cytokine Stimulus Positive Regulation Of Gene Expression
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