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TICAM1 and TNFAIP3
Number of citations of the paper that reports this interaction (PubMedID
15474016
)
0
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vivo)
TICAM1
TNFAIP3
Description
TIR domain containing adaptor molecule 1
TNF alpha induced protein 3
Image
GO Annotations
Cellular Component
Cytoplasm
Mitochondrion
Endosome
Early Endosome
Autophagosome
Cytosol
Endosome Membrane
Cytoplasmic Vesicle
Ripoptosome
Nucleus
Cytoplasm
Lysosome
Cytosol
Extracellular Exosome
Molecular Function
Protein Binding
Protein Kinase Binding
Signaling Adaptor Activity
Molecular Adaptor Activity
Protease Binding
DNA Binding
Catalytic Activity
Ubiquitin-protein Transferase Activity
Cysteine-type Deubiquitinase Activity
Protein Binding
Peptidase Activity
Cysteine-type Peptidase Activity
Zinc Ion Binding
Transferase Activity
Hydrolase Activity
Enzyme Binding
Kinase Binding
Identical Protein Binding
Ubiquitin Binding
Metal Ion Binding
K63-linked Deubiquitinase Activity
K63-linked Polyubiquitin Modification-dependent Protein Binding
Biological Process
Toll-like Receptor Signaling Pathway
Macrophage Activation Involved In Immune Response
Immune System Process
Positive Regulation Of Myeloid Dendritic Cell Cytokine Production
MyD88-independent Toll-like Receptor Signaling Pathway
Nitric Oxide Biosynthetic Process
Apoptotic Process
Inflammatory Response
Signal Transduction
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Autophagy
Positive Regulation Of Gene Expression
Positive Regulation Of B Cell Proliferation
Positive Regulation Of Protein Ubiquitination
Lipopolysaccharide-mediated Signaling Pathway
Positive Regulation Of Type I Interferon Production
Response To Lipopolysaccharide
Positive Regulation Of Chemokine Production
Positive Regulation Of Interferon-beta Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Natural Killer Cell Activation
Toll-like Receptor 3 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
B Cell Proliferation
B Cell Activation
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Protein-containing Complex Assembly
Response To Exogenous DsRNA
Innate Immune Response
Positive Regulation Of Nitric Oxide Biosynthetic Process
Positive Regulation Of B Cell Activation
Defense Response To Virus
Positive Regulation Of Macrophage Cytokine Production
Cellular Response To Lipopolysaccharide
Apoptotic Signaling Pathway
Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus
Positive Regulation Of Cytokine Production Involved In Inflammatory Response
B-1 B Cell Homeostasis
Response To Molecule Of Bacterial Origin
Immune System Process
Regulation Of Germinal Center Formation
Negative Regulation Of Chronic Inflammatory Response
Proteolysis
Apoptotic Process
Inflammatory Response
Cytoskeleton Organization
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Cell Migration
Protein Deubiquitination
Positive Regulation Of Wnt Signaling Pathway
Negative Regulation Of Protein Ubiquitination
Response To Muramyl Dipeptide
Negative Regulation Of Interleukin-1 Beta Production
Negative Regulation Of Interleukin-2 Production
Negative Regulation Of Interleukin-6 Production
Negative Regulation Of Tumor Necrosis Factor Production
Negative Regulation Of Toll-like Receptor 2 Signaling Pathway
Negative Regulation Of Toll-like Receptor 3 Signaling Pathway
Negative Regulation Of Toll-like Receptor 4 Signaling Pathway
Negative Regulation Of Toll-like Receptor 5 Signaling Pathway
Protein K11-linked Deubiquitination
Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway
Regulation Of Cell Population Proliferation
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of Bone Resorption
Negative Regulation Of Innate Immune Response
Negative Regulation Of Smooth Muscle Cell Proliferation
Regulation Of Defense Response To Virus By Host
Negative Regulation Of Inflammatory Response
Negative Regulation Of B Cell Activation
Regulation Of Vascular Wound Healing
Cellular Response To Hydrogen Peroxide
Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway
Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway
Protein K63-linked Deubiquitination
Protein K48-linked Ubiquitination
Protein K48-linked Deubiquitination
Cellular Response To Lipopolysaccharide
Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Tolerance Induction To Lipopolysaccharide
Establishment Of Protein Localization To Vacuole
Negative Regulation Of Osteoclast Proliferation
Cellular Response To Oxygen-containing Compound
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Positive Regulation Of Hepatocyte Proliferation
Negative Regulation Of CD40 Signaling Pathway
Negative Regulation Of Endothelial Cell Apoptotic Process
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
Caspase activation via Death Receptors in the presence of ligand
MyD88-independent TLR4 cascade
Toll Like Receptor 3 (TLR3) Cascade
TICAM1, RIP1-mediated IKK complex recruitment
RIP-mediated NFkB activation via ZBP1
TRIF-mediated programmed cell death
TICAM1 deficiency - HSE
TRAF3 deficiency - HSE
TLR3-mediated TICAM1-dependent programmed cell death
TICAM1-dependent activation of IRF3/IRF7
TICAM1,TRAF6-dependent induction of TAK1 complex
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)
IKK complex recruitment mediated by RIP1
TRAF6-mediated induction of TAK1 complex within TLR4 complex
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation
NOD1/2 Signaling Pathway
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
TNFR1-induced NF-kappa-B signaling pathway
Ovarian tumor domain proteases
Negative regulators of DDX58/IFIH1 signaling
Drugs
Diseases
GWAS
Basal cell carcinoma (
33549134
)
Medication use (thyroid preparations) (
31015401
)
Vitiligo (
22561518
27723757
)
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Asthma (
32296059
)
Autoimmune traits (pleiotropy) (
30572963
)
Cardiac Troponin-T levels (
23247143
)
Celiac disease (
20190752
22057235
)
Celiac disease and Rheumatoid arthritis (
26546613
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Cutaneous psoriasis (
26626624
)
Hodgkin's lymphoma (
30194254
)
Inflammatory bowel disease (
23128233
)
Inflammatory skin disease (
25574825
)
Malaria (
31844061
)
Multiple sclerosis (
24076602
)
Phosphatidylcholine-ether levels (
31551469
)
Primary biliary cholangitis (
26394269
)
Psoriasis (
25574825
19169254
25903422
20953190
23143594
)
Psoriasis vulgaris (
26626624
)
Rheumatoid arthritis (
24449572
24390342
23143596
20453841
32723749
30423114
17982456
)
Rheumatoid arthritis (ACPA-positive) (
24532676
23143596
)
Sjögren's syndrome (
24097066
24097067
)
Systemic lupus erythematosus (
19165918
28714469
27399966
26663301
26502338
23273568
19838195
19838193
)
Systemic lupus erythematosus and Systemic sclerosis (
23740937
)
Systemic lupus erythematosus or rheumatoid arthritis (
27193031
)
Systemic sclerosis (
28314753
)
Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) (
30573655
)
Tonsillectomy (
28928442
27182965
)
Type 1 diabetes (
34127860
)
Interacting Genes
25 interacting genes:
AZI2
IKBKE
IRF3
IRF7
MAVS
PIAS4
PIK3CA
RIPK1
RIPK3
SRSF4
TBK1
TICAM2
TIRAP
TLR2
TLR3
TNFAIP3
TRAF1
TRAF2
TRAF3
TRAF4
TRAF6
TRAM1
TRIM8
UBQLN1
WWP2
61 interacting genes:
ANKRD13D
ARRDC3
ATP2A2
CALCOCO2
CCDC50
CCDC90B
CHUK
CLEC4G
COL1A1
DRC4
FABP4
GIT2
GNAI2
IKBKB
IKBKG
LAPTM5
LNX1
MAP3K5
OCLN
PCBP1
PFKL
PIBF1
PSMA7
RAD23A
RBCK1
RIPK1
RLIM
RNF11
RNF14
RNF168
RNF216
RNF5
RPS15
RPS20
SNAI1
TAX1BP1
TICAM1
TIFA
TNIP1
TNIP2
TRAF1
TRAF2
TRAF6
TRIM2
TRIM23
TRIM3
TRIM5
TRIM8
UBC
UBE2D1
UBE2N
UBQLN1
UBXN6
YWHAB
YWHAE
YWHAG
YWHAH
YWHAQ
YWHAZ
ZFAND5
ZNF251
Entrez ID
148022
7128
HPRD ID
06350
01857
Ensembl ID
ENSG00000127666
ENSG00000118503
Uniprot IDs
Q8IUC6
P21580
PDB IDs
2M1X
2M63
3RC4
4BSX
4C0M
5JEL
9DK8
2EQE
2EQF
2EQG
2VFJ
3DKB
3OJ3
3OJ4
3VUW
3VUX
3VUY
3ZJD
3ZJE
3ZJF
3ZJG
5LRX
5V3B
5V3P
Enriched GO Terms of Interacting Partners
?
Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Type I Interferon Production
Positive Regulation Of Type I Interferon Production
Activation Of Innate Immune Response
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Intracellular Signal Transduction
Pattern Recognition Receptor Signaling Pathway
Positive Regulation Of Response To Cytokine Stimulus
Innate Immune Response-activating Signaling Pathway
Regulation Of Signal Transduction
Signaling Adaptor Activity
Defense Response To Virus
Defense Response
Positive Regulation Of Innate Immune Response
Activation Of Immune Response
Regulation Of Innate Immune Response
Regulation Of Immune Response
Positive Regulation Of Defense Response
Regulation Of Interferon-beta Production
Regulation Of Cell Communication
Regulation Of Signaling
Immune Response-activating Signaling Pathway
Positive Regulation Of Cytokine-mediated Signaling Pathway
Regulation Of Cytokine Production
Regulation Of Cytokine-mediated Signaling Pathway
Positive Regulation Of Immune Response
Positive Regulation Of Cytokine Production
Response To External Biotic Stimulus
Positive Regulation Of Signal Transduction
Response To Virus
Response To Stress
Response To Other Organism
Immune Response-regulating Signaling Pathway
Positive Regulation Of Intracellular Signal Transduction
Cell Surface Toll-like Receptor Signaling Pathway
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Toll-like Receptor Signaling Pathway
Positive Regulation Of Immune System Process
Type I Interferon-mediated Signaling Pathway
Innate Immune Response
Regulation Of Defense Response
Cell Surface Pattern Recognition Receptor Signaling Pathway
Immune System Process
Regulation Of Immune System Process
Cell Surface Receptor Signaling Pathway
Cytokine-mediated Signaling Pathway
Defense Response To Symbiont
Interferon-mediated Signaling Pathway
Identical Protein Binding
Protein Ubiquitination
Protein Polyubiquitination
Protein Modification By Small Protein Conjugation
Regulation Of Canonical NF-kappaB Signal Transduction
Post-translational Protein Modification
Ubiquitin Protein Ligase Activity
Regulation Of Intracellular Signal Transduction
Ubiquitin-protein Transferase Activity
Positive Regulation Of NF-kappaB Transcription Factor Activity
Modification-dependent Protein Catabolic Process
Regulation Of Cell Communication
Regulation Of Signaling
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Proteolysis Involved In Protein Catabolic Process
Regulation Of Signal Transduction
Positive Regulation Of DNA-binding Transcription Factor Activity
Ubiquitin-dependent Protein Catabolic Process
Cytoplasm
Positive Regulation Of Intracellular Signal Transduction
Macromolecule Catabolic Process
Regulation Of Immune Response
Protein Modification Process
Cytosol
Activation Of Innate Immune Response
Activation Of Immune Response
Protein K63-linked Ubiquitination
Immune Response-activating Signaling Pathway
Pattern Recognition Receptor Signaling Pathway
Signaling Adaptor Activity
Protein Metabolic Process
Positive Regulation Of Signal Transduction
Identical Protein Binding
Catabolic Process
Innate Immune Response-activating Signaling Pathway
Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of Immune Response
Positive Regulation Of Metabolic Process
Tumor Necrosis Factor-mediated Signaling Pathway
Immune Response-regulating Signaling Pathway
Protein Catabolic Process
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Innate Immune Response
Innate Immune Response Activating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Defense Response
Protein Sequestering Activity
Positive Regulation Of Innate Immune Response
Positive Regulation Of Immune System Process
Proteasomal Protein Catabolic Process
Cell Surface Toll-like Receptor Signaling Pathway
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Tagcloud (Intersection)
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