TICAM1 and TLR2

Number of citations of the paper that reports this interaction (PMID 12471095)
215

Data Source:
HPRD (in vivo)

		TICAM1	TLR2
Gene Name		toll-like receptor adaptor molecule 1	toll-like receptor 2
Image
Gene Ontology Annotations	Cellular Component	Cytosol Endosome Membrane Ripoptosome	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Toll-like Receptor 1-Toll-like Receptor 2 Protein Complex Toll-like Receptor 2-Toll-like Receptor 6 Protein Complex Cell Projection Cell Body
	Molecular Function	Signal Transducer Activity Protein Binding Protein Kinase Binding	Lipopolysaccharide Receptor Activity Receptor Activity Transmembrane Signaling Receptor Activity Protein Binding Signaling Pattern Recognition Receptor Activity Triacyl Lipopeptide Binding Diacyl Lipopeptide Binding Peptidoglycan Binding Protein Heterodimerization Activity Lipoteichoic Acid Binding
	Biological Process	Toll-like Receptor Signaling Pathway Macrophage Activation Involved In Immune Response MyD88-independent Toll-like Receptor Signaling Pathway Inflammatory Response I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of B Cell Proliferation Positive Regulation Of Protein Ubiquitination Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Protein Binding Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Natural Killer Cell Activation Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Exogenous DsRNA Regulation Of Protein Homodimerization Activity Positive Regulation Of Chemokine Biosynthetic Process Innate Immune Response Positive Regulation Of Interferon-beta Biosynthetic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Apoptotic Signaling Pathway	Response To Hypoxia Microglial Cell Activation Toll-like Receptor Signaling Pathway Response To Molecule Of Fungal Origin Positive Regulation Of Leukocyte Migration Cell Surface Pattern Recognition Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Leukotriene Metabolic Process Apoptotic Process Inflammatory Response Immune Response Signal Transduction I-kappaB Phosphorylation Negative Regulation Of Cell Proliferation Response To Toxic Substance Positive Regulation Of Wnt Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Central Nervous System Myelin Formation Response To Progesterone Negative Regulation Of Interleukin-12 Production Negative Regulation Of Interleukin-17 Production Positive Regulation Of Chemokine Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-18 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Response To Insulin Positive Regulation Of Toll-like Receptor Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Positive Regulation Of NF-kappaB Import Into Nucleus Detection Of Triacyl Bacterial Lipopeptide Detection Of Diacyl Bacterial Lipopeptide Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Chloramphenicol Transport Negative Regulation Of Growth Of Symbiont In Host Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Nitric Oxide Metabolic Process Positive Regulation Of Oligodendrocyte Differentiation Positive Regulation Of Cytokine Secretion Positive Regulation Of Inflammatory Response Defense Response To Gram-positive Bacterium Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Induction By Symbiont Of Defense-related Host Nitric Oxide Production Positive Regulation Of Macrophage Cytokine Production Response To Fatty Acid Cellular Response To Bacterial Lipopeptide Cellular Response To Lipoteichoic Acid Cellular Response To Peptidoglycan Cellular Response To Diacyl Bacterial Lipopeptide Cellular Response To Triacyl Bacterial Lipopeptide
Pathways		TRAF6 mediated induction of TAK1 complex TRIF-mediated TLR3/TLR4 signaling IKK complex recruitment mediated by RIP1 Cytosolic sensors of pathogen-associated DNA MyD88-independent cascade RIP-mediated NFkB activation via ZBP1 Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon Activated TLR4 signalling Toll-Like Receptors Cascades ZBP1(DAI) mediated induction of type I IFNs Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade TRIF-mediated programmed cell death Innate Immune System	Toll Like Receptor 2 (TLR2) Cascade Activated TLR4 signalling Toll Like Receptor TLR1:TLR2 Cascade Toll-Like Receptors Cascades Toll Like Receptor 4 (TLR4) Cascade Beta defensins MyD88:Mal cascade initiated on plasma membrane Defensins Toll Like Receptor TLR6:TLR2 Cascade Innate Immune System
Drugs			OspA lipoprotein S-(Dimethylarsenic)Cysteine
Diseases
GWAS		Vitiligo ( 22561518)
Protein-Protein Interactions		23 interactors: AZI2 IKBKE IRF3 IRF7 MAVS PIAS4 PIK3CA RIPK1 RIPK3 SRSF4 TBK1 TICAM2 TIRAP TLR2 TLR3 TNFAIP3 TRAF1 TRAF2 TRAF3 TRAF4 TRAF6 TRAM1 UBQLN1	18 interactors: CD14 HMGB1 HRAS HSP90B1 IRAK1 LY96 MAPK8IP3 MYD88 PIK3R1 RAC1 RIPK2 TICAM1 TIRAP TLR1 TLR10 TLR6 TOLLIP TRIP6
Entrez ID		148022	7097
HPRD ID		06350	04323
Ensembl ID		ENSG00000127666
Uniprot IDs		Q8IUC6	B3KWR9 O60603
PDB IDs		3RC4	1FYW 1FYX 1O77 2Z7X 2Z80
Enriched GO Terms of Interacting Partners?		Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway Regulation Of Innate Immune Response Regulation Of Type I Interferon Production TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Immune Response-regulating Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Immune Response Regulation Of Cytokine Production Innate Immune Response Regulation Of Immune Response Regulation Of Interferon-beta Production Positive Regulation Of Immune System Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cytokine Production Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Immune System Process Immune Response Positive Regulation Of Intracellular Signal Transduction Defense Response Positive Regulation Of Type I Interferon Production Immune System Process Intracellular Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Interferon-beta Production Regulation Of Signaling Regulation Of Intracellular Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity NIK/NF-kappaB Signaling Regulation Of Toll-like Receptor Signaling Pathway Negative Regulation Of Type I Interferon Production Signal Transduction Regulation Of Protein Metabolic Process Positive Regulation Of Interferon-alpha Production Negative Regulation Of Cytokine Production Cellular Response To Stimulus Positive Regulation Of Protein Metabolic Process Signaling Cell Communication Apoptotic Process Programmed Cell Death	Toll-like Receptor Signaling Pathway Innate Immune Response Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Immune Response-regulating Signaling Pathway Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response MyD88-dependent Toll-like Receptor Signaling Pathway Immune Response Defense Response Regulation Of Innate Immune Response Inflammatory Response Regulation Of Immune Response Positive Regulation Of Immune Response Toll-like Receptor 4 Signaling Pathway Cellular Response To Molecule Of Bacterial Origin Positive Regulation Of Immune System Process Immune System Process Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Immune System Process Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Response To Stress Positive Regulation Of Protein Metabolic Process Regulation Of Tumor Necrosis Factor Production Response To Molecule Of Bacterial Origin Intracellular Signal Transduction Regulation Of Cytokine Production I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Interleukin-6 Production Positive Regulation Of Signal Transduction Response To External Stimulus Response To Bacterium Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Interleukin-6 Production Positive Regulation Of Cytokine Production Lipopolysaccharide-mediated Signaling Pathway Signal Transduction Cellular Response To Stimulus Regulation Of Protein Metabolic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of JNK Cascade Signaling Cell Communication Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Response To Other Organism
Tagcloud ?		alters annotation ca3 candidate cdh23 dataset disequilibrium ear fdr filtering gwas harbored hist3h3 hypotheses hypothetical icsnpathway il27ra innate modulates morphogenesis pneumoconiosis ptprz1 rs11592462 rs2230656 rs2292151 rs8120 snps stereocilia strongest	1racp abilities analysed ankylosing asdas basdai basfi bath besides box chromosomal compare correlations crp elisa erythrocytesedimentationrate esr from71 healthy hmgb1 index mobility pbmcs rage remarkably spondylitis surface tlr4 untreated
Tagcloud (Difference) ?		alters annotation ca3 candidate cdh23 dataset disequilibrium ear fdr filtering gwas harbored hist3h3 hypotheses hypothetical icsnpathway il27ra innate modulates morphogenesis pneumoconiosis ptprz1 rs11592462 rs2230656 rs2292151 rs8120 snps stereocilia strongest	1racp abilities analysed ankylosing asdas basdai basfi bath besides box chromosomal compare correlations crp elisa erythrocytesedimentationrate esr from71 healthy hmgb1 index mobility pbmcs rage remarkably spondylitis surface tlr4 untreated
Tagcloud (Intersection) ?