TICAM1 and AZI2

Number of citations of the paper that reports this interaction (PMID 15611223)
21

Data Source:
HPRD (in vivo)

		TICAM1	AZI2
Gene Name		toll-like receptor adaptor molecule 1	5-azacytidine induced 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Endosome Membrane Ripoptosome	Cytoplasm
	Molecular Function	Signal Transducer Activity Protein Binding Protein Kinase Binding	Protein Binding
	Biological Process	Toll-like Receptor Signaling Pathway Macrophage Activation Involved In Immune Response MyD88-independent Toll-like Receptor Signaling Pathway Inflammatory Response I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of B Cell Proliferation Positive Regulation Of Protein Ubiquitination Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Protein Binding Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Natural Killer Cell Activation Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Exogenous DsRNA Regulation Of Protein Homodimerization Activity Positive Regulation Of Chemokine Biosynthetic Process Innate Immune Response Positive Regulation Of Interferon-beta Biosynthetic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Apoptotic Signaling Pathway	Mitotic Cell Cycle I-kappaB Kinase/NF-kappaB Signaling Interferon-alpha Production Interferon-gamma Production Interleukin-6 Production Tumor Necrosis Factor Production T Cell Activation Dendritic Cell Proliferation Dendritic Cell Differentiation
Pathways		TRAF6 mediated induction of TAK1 complex TRIF-mediated TLR3/TLR4 signaling IKK complex recruitment mediated by RIP1 Cytosolic sensors of pathogen-associated DNA MyD88-independent cascade RIP-mediated NFkB activation via ZBP1 Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon Activated TLR4 signalling Toll-Like Receptors Cascades ZBP1(DAI) mediated induction of type I IFNs Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade TRIF-mediated programmed cell death Innate Immune System
Drugs
Diseases
GWAS		Vitiligo ( 22561518)
Protein-Protein Interactions		23 interactors: AZI2 IKBKE IRF3 IRF7 MAVS PIAS4 PIK3CA RIPK1 RIPK3 SRSF4 TBK1 TICAM2 TIRAP TLR2 TLR3 TNFAIP3 TRAF1 TRAF2 TRAF3 TRAF4 TRAF6 TRAM1 UBQLN1	11 interactors: APBA3 IKBKE MIB1 MTPAP N4BP1 ODC1 RNF31 TBK1 TICAM1 TRAF3 TXLNA
Entrez ID		148022	64343
HPRD ID		06350	10577
Ensembl ID		ENSG00000127666	ENSG00000163512
Uniprot IDs		Q8IUC6	Q9H6S1
PDB IDs		3RC4
Enriched GO Terms of Interacting Partners?		Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway Regulation Of Innate Immune Response Regulation Of Type I Interferon Production TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Immune Response-regulating Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Immune Response Regulation Of Cytokine Production Innate Immune Response Regulation Of Immune Response Regulation Of Interferon-beta Production Positive Regulation Of Immune System Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cytokine Production Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Immune System Process Immune Response Positive Regulation Of Intracellular Signal Transduction Defense Response Positive Regulation Of Type I Interferon Production Immune System Process Intracellular Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Interferon-beta Production Regulation Of Signaling Regulation Of Intracellular Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity NIK/NF-kappaB Signaling Regulation Of Toll-like Receptor Signaling Pathway Negative Regulation Of Type I Interferon Production Signal Transduction Regulation Of Protein Metabolic Process Positive Regulation Of Interferon-alpha Production Negative Regulation Of Cytokine Production Cellular Response To Stimulus Positive Regulation Of Protein Metabolic Process Signaling Cell Communication Apoptotic Process Programmed Cell Death	TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Regulation Of Type I Interferon Production Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Regulation Of Interferon-beta Production Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Type I Interferon Production Positive Regulation Of Innate Immune Response Immune Response-regulating Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Innate Immune Response Positive Regulation Of Interferon-beta Biosynthetic Process Positive Regulation Of Immune Response Regulation Of Immune Response Positive Regulation Of Immune System Process Positive Regulation Of Interferon-beta Production Regulation Of Cytokine Production Negative Regulation Of Cytokine Production Regulation Of Immune System Process Immune System Process Response To Virus Innate Immune Response Positive Regulation Of Intracellular Signal Transduction Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Cytokine Biosynthetic Process Putrescine Biosynthetic Process From Ornithine Positive Regulation Of Type I Interferon Production CD40 Signaling Pathway Regulation Of Cytokine Biosynthetic Process Leukocyte Activation Protein Linear Polyubiquitination Putrescine Biosynthetic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Dendritic Cell Proliferation Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Protein Ubiquitination Immune Response Protein Modification By Small Protein Conjugation Defense Response Defense Response To Virus Cell Activation Ornithine Metabolic Process Response To Other Organism
Tagcloud ?		alters annotation ca3 candidate cdh23 dataset disequilibrium ear fdr filtering gwas harbored hist3h3 hypotheses hypothetical icsnpathway il27ra innate modulates morphogenesis pneumoconiosis ptprz1 rs11592462 rs2230656 rs2292151 rs8120 snps stereocilia strongest	activator ag azacytidine cdcs clarified critical csf cycling dcs defects dendritic dispensable efficiency efficient generation gm ifn ifns immunization marrow member nap1 none production reciprocally tank tbk1 tbkbp1 tnfr
Tagcloud (Difference) ?		alters annotation ca3 candidate cdh23 dataset disequilibrium ear fdr filtering gwas harbored hist3h3 hypotheses hypothetical icsnpathway il27ra innate modulates morphogenesis pneumoconiosis ptprz1 rs11592462 rs2230656 rs2292151 rs8120 snps stereocilia strongest	activator ag azacytidine cdcs clarified critical csf cycling dcs defects dendritic dispensable efficiency efficient generation gm ifn ifns immunization marrow member nap1 none production reciprocally tank tbk1 tbkbp1 tnfr
Tagcloud (Intersection) ?