DUSP19 and ALAS1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		DUSP19	ALAS1
Gene Name		dual specificity phosphatase 19	5-aminolevulinate synthase 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm	Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Matrix
	Molecular Function	Protein Tyrosine Phosphatase Activity Protein Kinase Inhibitor Activity MAP-kinase Scaffold Activity Protein Tyrosine/threonine Phosphatase Activity JUN Kinase Phosphatase Activity Protein Kinase Activator Activity Mitogen-activated Protein Kinase Kinase Kinase Binding	5-aminolevulinate Synthase Activity Pyridoxal Phosphate Binding
	Biological Process	Inactivation Of MAPK Activity Negative Regulation Of Protein Kinase Activity Protein Dephosphorylation JNK Cascade Peptidyl-tyrosine Dephosphorylation Positive Regulation Of MAPK Cascade Positive Regulation Of JUN Kinase Activity Negative Regulation Of JUN Kinase Activity Positive Regulation Of Protein Kinase Activity Negative Regulation Of JNK Cascade Positive Regulation Of JNK Cascade	Porphyrin-containing Compound Metabolic Process Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Organelle Organization Mitochondrion Organization Cellular Lipid Metabolic Process Small Molecule Metabolic Process
Pathways			PPARA activates gene expression Heme biosynthesis Organelle biogenesis and maintenance Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Metabolism of porphyrins Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Transcriptional activation of mitochondrial biogenesis Mitochondrial biogenesis
Drugs			Pyridoxal Phosphate Glycine
Diseases
GWAS			Bipolar disorder ( 21926972)
Protein-Protein Interactions		4 interactors: ALAS1 MAP2K7 MAP3K5 MAPK9	40 interactors: BCL7A C2orf42 C8orf33 CCHCR1 CDC73 CDK5 CDKN1A CERK DUSP19 EP400 FAM127C GNL3L KLHL35 LONRF1 MTFR2 NUDT3 PIK3CB PLAU POLDIP2 PPL RAP1B SH2D4A SNX20 STAMBP SUMO2 TCEA2 TEKT4 TK1 TMSB10 TMSB4X TMSB4XP1 TMSB4XP2 TMSB4XP6 TTC23 USP20 WIPF1 ZFYVE26 ZMAT1 ZNF175 ZNF564
Entrez ID		142679	211
HPRD ID		13254	00505
Ensembl ID		ENSG00000162999	ENSG00000023330
Uniprot IDs		Q8WTR2	P13196 Q5JAM2
PDB IDs		3S4E
Enriched GO Terms of Interacting Partners?		JNK Cascade Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Regulation Of JNK Cascade Regulation Of Stress-activated MAPK Cascade MAPK Cascade Signal Transduction By Phosphorylation Activation Of JUN Kinase Activity Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of JUN Kinase Activity Positive Regulation Of Neuron Death Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Cell Death Regulation Of MAPK Cascade Regulation Of JUN Kinase Activity Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Protein Phosphorylation Zymogen Activation Toll-like Receptor Signaling Pathway Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Innate Immune Response Positive Regulation Of JNK Cascade Positive Regulation Of Cysteine-type Endopeptidase Activity Response To Tumor Necrosis Factor Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Endopeptidase Activity Positive Regulation Of Phosphorylation Innate Immune Response-activating Signal Transduction Response To UV Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Activation Of MAPK Activity Activation Of Innate Immune Response Positive Regulation Of Protein Modification Process Positive Regulation Of Peptidase Activity Apoptotic Process Programmed Cell Death Cell Death	Sequestering Of Actin Monomers Blood Coagulation Hemostasis Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity
Tagcloud ?			adequate arf1 candidate eif2b1 fbxw2 genorm gusb housekeeping hprt1 hysterectomy ideal leiomyoma menopausal menstrual mrpl19 myometrial myometrium normalization normfinder phases proliferative pum1 regardless secretory softwares standards taqman trim27 ube2d2
Tagcloud (Difference) ?			adequate arf1 candidate eif2b1 fbxw2 genorm gusb housekeeping hprt1 hysterectomy ideal leiomyoma menopausal menstrual mrpl19 myometrial myometrium normalization normfinder phases proliferative pum1 regardless secretory softwares standards taqman trim27 ube2d2
Tagcloud (Intersection) ?