CPB2 and A2M

Number of citations of the paper that reports this interaction (PMID 8662763)
4

Data Source:
BioGRID (pull down)

		CPB2	A2M
Gene Name		carboxypeptidase B2 (plasma)	alpha-2-macroglobulin
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Extracellular Vesicular Exosome	Extracellular Region Cytosol Platelet Alpha Granule Lumen Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Metallocarboxypeptidase Activity Zinc Ion Binding	Protease Binding Serine-type Endopeptidase Inhibitor Activity Receptor Binding Protein Binding Growth Factor Binding Enzyme Binding Interleukin-8 Binding Interleukin-1 Binding Tumor Necrosis Factor Binding Calcium-dependent Protein Binding
	Biological Process	Positive Regulation Of Extracellular Matrix Constituent Secretion Proteolysis Blood Coagulation Response To Heat Negative Regulation Of Plasminogen Activation Response To Drug Fibrinolysis Negative Regulation Of Fibrinolysis Cellular Response To Glucose Stimulus Liver Regeneration Negative Regulation Of Hepatocyte Proliferation	Negative Regulation Of Complement Activation, Lectin Pathway Platelet Degranulation Small GTPase Mediated Signal Transduction Blood Coagulation Blood Coagulation, Intrinsic Pathway Negative Regulation Of Endopeptidase Activity Extracellular Matrix Disassembly Platelet Activation Extracellular Matrix Organization Stem Cell Differentiation Regulation Of Small GTPase Mediated Signal Transduction
Pathways		Peptide hormone metabolism Metabolism of Angiotensinogen to Angiotensins	Lipoprotein metabolism Metabolism of lipids and lipoproteins Platelet degranulation Lipid digestion, mobilization, and transport Degradation of the extracellular matrix Formation of Fibrin Clot (Clotting Cascade) Rho GTPase cycle Intrinsic Pathway HDL-mediated lipid transport Response to elevated platelet cytosolic Ca2+ Signaling by Rho GTPases Platelet activation, signaling and aggregation
Drugs			Becaplermin Bacitracin Ocriplasmin
Diseases
GWAS
Protein-Protein Interactions		7 interactors: A2M C5 F2 PLG PZP TINAG UBC	93 interactors: ACTB ADAM19 ADAMTS1 AMBP ANXA6 ANXA7 AP1M2 APOE APP ATF7IP ATP1A1 B2M C11orf58 CDC37 CDC42 CDK2AP2 CDKN1A CELA1 CPB2 CTSB CTSE CYP2C18 CYP2C8 DNAJB1 ECSIT EGLN2 ELAVL3 ENO2 EVI5L EXOSC1 FARSA FBXL12 FBXW4 FIS1 GCDH GEM GRB2 H2AFX HMOX2 HSPA5 IFIT3 IFIT5 IGSF8 IL10 IL1B IL4 KLK13 KLK2 KLK3 LCAT LEP LONP1 LRP1 LYZ MAST1 MGEA5 MLST8 MMP2 MYOC NCDN NGF NOS3 NUDT21 PAEP PAXIP1 PDGFA PDGFB PRAM1 PRDX2 RAB3A RAD23A RAP1B RETN RHEB RNF32 RPP14 SEPT8 SHBG SMN1 STAMBPL1 SWSAP1 TGFBI TGIF1 TGM2 TK1 TNFRSF14 TRAPPC5 TSC22D1 TTR TUBA1B TYRO3 UFD1L UMPS
Entrez ID		1361	2
HPRD ID		04374	00072
Ensembl ID		ENSG00000080618	ENSG00000175899
Uniprot IDs		Q96IY4	P01023
PDB IDs		3D66 3D67 3D68 3LMS	1BV8 2P9R 4ACQ
Enriched GO Terms of Interacting Partners?		Regulation Of Proteolysis Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Protein Processing Negative Regulation Of Fibrinolysis Regulation Of Fibrinolysis Blood Coagulation, Intrinsic Pathway Protein Activation Cascade Platelet Activation Leukocyte Migration Fibrinolysis Positive Regulation Of Blood Coagulation Negative Regulation Of Catalytic Activity Regulation Of Complement Activation Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Positive Regulation Of Coagulation Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Wound Healing Regulation Of Humoral Immune Response Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Blood Coagulation Immune System Process Regulation Of Protein Metabolic Process Negative Regulation Of Coagulation Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Negative Regulation Of Wound Healing Regulation Of Peptidase Activity Platelet Degranulation Blood Coagulation Hemostasis Regulation Of Acute Inflammatory Response Positive Regulation Of Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Extracellular Matrix Disassembly Regulation Of Blood Coagulation Regulation Of Body Fluid Levels Proteolysis Wound Healing Negative Regulation Of Macrophage Chemotaxis Negative Regulation Of Complement Activation, Lectin Pathway Regulation Of Wound Healing Activation Of MAPK Activity Cell Activation Response To Wounding Cellular Homeostasis Mononuclear Cell Migration Regulation Of Intracellular Signal Transduction	Response To Abiotic Stimulus Response To Stress Regulation Of Cell Activation Response To Stimulus Response To External Stimulus Developmental Process Anatomical Structure Development Regulation Of Immune Response Response To Organic Substance Cellular Response To Stimulus Response To Drug System Development Multicellular Organismal Development Hemostasis Defense Response Regulation Of Cellular Component Organization Regulation Of Body Fluid Levels Regulation Of Immune System Process Blood Coagulation Negative Regulation Of Blood Coagulation Regulation Of Cell Proliferation Positive Regulation Of Protein Metabolic Process Negative Regulation Of Coagulation Organ Development Cellular Response To Organic Substance Negative Regulation Of Wound Healing Regulation Of Protein Metabolic Process Response To Hormone Catabolic Process Negative Regulation Of Platelet Activation Positive Regulation Of Cellular Protein Metabolic Process Platelet Activation Phosphatidylinositol-mediated Signaling Immune Response Regulation Of Phosphorylation Regulation Of Signaling Reproductive Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Apoptotic Process Positive Regulation Of DNA Metabolic Process Anatomical Structure Morphogenesis Regulation Of Phosphorus Metabolic Process Cell Surface Receptor Signaling Pathway Innate Immune Response Response To Wounding Positive Regulation Of Cell Activation Regulation Of Lymphocyte Activation Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Cellular Protein Metabolic Process Wound Healing
Tagcloud ?		3t3 authentic binds block bovine cap cdcl2 complementation defect demonstrates eukaryotic influenza inserted m7gpppnm metallothionein mrnas mt nih papilloma produces product recognizes recombinant relieves strand transfection vector viral	a1at aptt clauss coaliza eclt euglobulin fbg fibrinolysis fibrinolytic foetopathy foetus gdm haemostasis hemocoagulation interleukins kabi les leucocytic macroglobulin microturbidimetry orm orosomucoid prea prealbumin proteinases thrombocytes thrombophilia varicosities wither
Tagcloud (Difference) ?		3t3 authentic binds block bovine cap cdcl2 complementation defect demonstrates eukaryotic influenza inserted m7gpppnm metallothionein mrnas mt nih papilloma produces product recognizes recombinant relieves strand transfection vector viral	a1at aptt clauss coaliza eclt euglobulin fbg fibrinolysis fibrinolytic foetopathy foetus gdm haemostasis hemocoagulation interleukins kabi les leucocytic macroglobulin microturbidimetry orm orosomucoid prea prealbumin proteinases thrombocytes thrombophilia varicosities wither
Tagcloud (Intersection) ?