CPB2 and A2M

Number of citations of the paper that reports this interaction (PubMedID 8662763)
0

Data Source:
BioGRID (pull down)

		CPB2	A2M
Description		carboxypeptidase B2	alpha-2-macroglobulin
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Exosome	Extracellular Region Extracellular Space Extracellular Matrix Platelet Alpha Granule Lumen Extracellular Exosome Blood Microparticle
	Molecular Function	Carboxypeptidase Activity Metallocarboxypeptidase Activity Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding	Protease Binding Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Signaling Receptor Binding Protein Binding Growth Factor Binding Enzyme Binding Interleukin-8 Binding Interleukin-1 Binding Peptidase Inhibitor Activity Tumor Necrosis Factor Binding Calcium-dependent Protein Binding
	Biological Process	Proteolysis Blood Coagulation Hemostasis Fibrinolysis	Negative Regulation Of Complement Activation, Lectin Pathway Stem Cell Differentiation
Pathways		Metabolism of Angiotensinogen to Angiotensins Regulation of Complement cascade	Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Degradation of the extracellular matrix HDL assembly
Drugs		AZD-9684 Prothrombin	Becaplermin Cisplatin Bacitracin Zinc Ocriplasmin Silver Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355) Thrombin-activatable fibrinolysis inhibitor levels ( 29378355)	Refractive error ( 32231278)
Interacting Genes		6 interacting genes: A2M C5 F2 PLG PZP TINAG	99 interacting genes: ACTB ADAM19 ADAMTS1 AMBP ANXA6 ANXA7 AP1M2 APOE APP ATF7IP ATP1A1 B2M C11orf58 CDC37 CDC42 CDK2AP2 CDKN1A CELA1 CPB2 CTSB CTSE CYP2C18 CYP2C8 DNAJB1 ECSIT EGLN2 ELAVL3 ENO2 EVI5L EXOSC1 FARSA FBXL12 FBXW4 FIS1 GCDH GEM GRB2 H2AX HMOX2 HSP90AA1 HSPA5 HSPB2 IFIT3 IFIT5 IGSF8 IL10 IL1B IL4 KLK1 KLK13 KLK2 KLK3 LCAT LEP LINC02582 LONP1 LRP1 LYZ MAST1 MLST8 MMP2 MYOC NCDN NGF NOS3 NUDT21 OGA PAEP PAXIP1 PDGFA PDGFB PRAM1 PRDX2 RAB3A RAD23A RAP1B RETN RHEB RNF32 RPP14 SEPTIN8 SHBG SLC6A4 SMN1 STAMBPL1 SWSAP1 TGFBI TGIF1 TGM2 TK1 TNFRSF14 TRAPPC5 TSC22D1 TTR TUBA1B TYRO3 UFD1 UMPS USP40
Entrez ID		1361	2
HPRD ID		04374	00072
Ensembl ID		ENSG00000080618	ENSG00000175899
Uniprot IDs		A0A087WSY5 Q96IY4	P01023
PDB IDs		3D66 3D67 3D68 3LMS 4P10 5HVF 5HVG 5HVH 7NEE 7NEU	1BV8 2P9R 6TAV 7O7L 7O7M 7O7N 7O7O 7O7P 7O7Q 7O7R 7O7S 7VON 7VOO
Enriched GO Terms of Interacting Partners?		Blood Microparticle Endopeptidase Inhibitor Activity Extracellular Space Signaling Receptor Binding Protease Binding Extracellular Matrix Negative Regulation Of Fibrinolysis Extracellular Region Regulation Of Fibrinolysis Fibrinolysis Positive Regulation Of Blood Coagulation Positive Regulation Of Coagulation Biological Process Involved In Interaction With Symbiont Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Platelet Alpha Granule Lumen Extracellular Exosome Uracil Binding Beta-alanine Metabolic Process Thymidine Catabolic Process Beta-alanine Biosynthetic Process Dihydropyrimidine Dehydrogenase (NADP+) Activity Positive Regulation Of Wound Healing Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Blood Coagulation Serine-type Endopeptidase Inhibitor Activity Endopeptidase Activity Negative Regulation Of Complement Activation, Lectin Pathway Uracil Catabolic Process Coagulation Blood Coagulation Peptidase Inhibitor Activity Hemostasis Interleukin-8 Binding Receptor Ligand Activity Killing Of Cells Of Another Organism Pyrimidine Nucleoside Catabolic Process Thymine Metabolic Process Thymine Catabolic Process Purine Nucleobase Catabolic Process Serine-type Peptidase Activity Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Regulation Of Wound Healing CMP Catabolic Process DUMP Catabolic Process Thrombospondin Receptor Activity Serine-type Endopeptidase Activity Trans-synaptic Signaling By BDNF	Negative Regulation Of Multicellular Organismal Process Extracellular Exosome Extracellular Space Peptidase Activity Ovulation From Ovarian Follicle Regulation Of Cell Activation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Hydrolase Activity Ovulation Regulation Of Multicellular Organismal Process Response To Stress Regulation Of Blood Coagulation Negative Regulation Of Platelet Activation Regulation Of Hemostasis Extracellular Region Regulation Of Amyloid-beta Clearance Positive Regulation Of Cell Adhesion Smooth Muscle Adaptation Regulation Of Programmed Cell Death Regulation Of Immune Response Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Positive Regulation Of Amyloid-beta Clearance Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Proteolysis Negative Regulation Of Coagulation Regulation Of Cell Adhesion Regulation Of Biological Quality Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Apoptotic Process Positive Regulation Of Cell Activation Identical Protein Binding Positive Regulation Of Protein Metabolic Process Protein Refolding Positive Regulation Of Cell Migration Positive Regulation Of Multicellular Organismal Process Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Lymphocyte Activation Regulation Of Transport Melanosome Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Smooth Muscle Cell Proliferation Serine-type Endopeptidase Activity Positive Regulation Of Cell Motility Extracellular Matrix Lipoprotein Particle Platelet-derived Growth Factor Complex Negative Regulation Of Phosphatidylinositol Biosynthetic Process Regulation Of Nitric Oxide Metabolic Process
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