CPB2

Description		carboxypeptidase B2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Exosome
	Molecular Function	Carboxypeptidase Activity Metallocarboxypeptidase Activity Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Proteolysis Blood Coagulation Hemostasis Fibrinolysis
Pathways		Metabolism of Angiotensinogen to Angiotensins Regulation of Complement cascade
Drugs		AZD-9684 Prothrombin
Diseases
GWAS		Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355) Thrombin-activatable fibrinolysis inhibitor levels ( 29378355)
Novel Interacting Genes		1 novel interacting genes: DPYD
Interacting Genes		6 interacting genes: A2M C5 F2 PLG PZP TINAG
Entrez ID		1361
HPRD ID		04374
Ensembl ID		ENSG00000080618
Uniprot IDs		A0A087WSY5 Q96IY4
PDB IDs		3D66 3D67 3D68 3LMS 4P10 5HVF 5HVG 5HVH 7NEE 7NEU
Enriched GO Terms of Interacting Partners?		Blood Microparticle Endopeptidase Inhibitor Activity Extracellular Space Signaling Receptor Binding Protease Binding Extracellular Matrix Negative Regulation Of Fibrinolysis Extracellular Region Regulation Of Fibrinolysis Fibrinolysis Positive Regulation Of Blood Coagulation Positive Regulation Of Coagulation Biological Process Involved In Interaction With Symbiont Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Platelet Alpha Granule Lumen Extracellular Exosome Uracil Binding Beta-alanine Metabolic Process Thymidine Catabolic Process Beta-alanine Biosynthetic Process Dihydropyrimidine Dehydrogenase (NADP+) Activity Positive Regulation Of Wound Healing Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Blood Coagulation Serine-type Endopeptidase Inhibitor Activity Endopeptidase Activity Negative Regulation Of Complement Activation, Lectin Pathway Uracil Catabolic Process Coagulation Blood Coagulation Peptidase Inhibitor Activity Hemostasis Interleukin-8 Binding Receptor Ligand Activity Killing Of Cells Of Another Organism Pyrimidine Nucleoside Catabolic Process Thymine Metabolic Process Thymine Catabolic Process Purine Nucleobase Catabolic Process Serine-type Peptidase Activity Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Regulation Of Wound Healing CMP Catabolic Process DUMP Catabolic Process Thrombospondin Receptor Activity Serine-type Endopeptidase Activity Trans-synaptic Signaling By BDNF
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