CPB2 and C5

Number of citations of the paper that reports this interaction (PMID 11939578)
21

Data Source:
BioGRID (enzymatic study)

		CPB2	C5
Gene Name		carboxypeptidase B2 (plasma)	complement component 5
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Extracellular Vesicular Exosome	Extracellular Region Membrane Attack Complex Extracellular Space Extracellular Vesicular Exosome
	Molecular Function	Metallocarboxypeptidase Activity Zinc Ion Binding	Endopeptidase Inhibitor Activity Receptor Binding Protein Binding Chemokine Activity C5a Anaphylatoxin Chemotactic Receptor Binding
	Biological Process	Positive Regulation Of Extracellular Matrix Constituent Secretion Proteolysis Blood Coagulation Response To Heat Negative Regulation Of Plasminogen Activation Response To Drug Fibrinolysis Negative Regulation Of Fibrinolysis Cellular Response To Glucose Stimulus Liver Regeneration Negative Regulation Of Hepatocyte Proliferation	Activation Of MAPK Activity In Utero Embryonic Development Leukocyte Migration Involved In Inflammatory Response Cellular Calcium Ion Homeostasis Chemotaxis Response To Stress Inflammatory Response Complement Activation Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Positive Regulation Vascular Endothelial Growth Factor Production Negative Regulation Of Norepinephrine Secretion Negative Regulation Of Macrophage Chemotaxis Negative Regulation Of Endopeptidase Activity Cytolysis Regulation Of Complement Activation Negative Regulation Of Dopamine Secretion Glucose Homeostasis Innate Immune Response Positive Regulation Of Angiogenesis Positive Regulation Of Chemotaxis Cell Chemotaxis Positive Regulation Of Chemokine Secretion
Pathways		Peptide hormone metabolism Metabolism of Angiotensinogen to Angiotensins	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Class A/1 (Rhodopsin-like receptors) Activation of C3 and C5 Terminal pathway of complement Metabolic disorders of biological oxidation enzymes GPCR ligand binding GPCR downstream signaling Regulation of Complement cascade Peptide ligand-binding receptors Complement cascade G alpha (i) signalling events Innate Immune System
Drugs			Intravenous Immunoglobulin Eculizumab
Diseases
GWAS			Rheumatoid arthritis ( 20453842 19503088)
Protein-Protein Interactions		7 interactors: A2M C5 F2 PLG PZP TINAG UBC	9 interactors: C2 C3 C5AR1 C6 C7 C8B CPB2 CPN1 CREB3L1
Entrez ID		1361	727
HPRD ID		04374	00405
Ensembl ID		ENSG00000080618	ENSG00000106804
Uniprot IDs		Q96IY4	P01031
PDB IDs		3D66 3D67 3D68 3LMS	1CFA 1KJS 1XWE 3CU7 3HQA 3HQB 3KLS 3KM9 3PRX 3PVM 4A5W 4E0S
Enriched GO Terms of Interacting Partners?		Regulation Of Proteolysis Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Protein Processing Negative Regulation Of Fibrinolysis Regulation Of Fibrinolysis Blood Coagulation, Intrinsic Pathway Protein Activation Cascade Platelet Activation Leukocyte Migration Fibrinolysis Positive Regulation Of Blood Coagulation Negative Regulation Of Catalytic Activity Regulation Of Complement Activation Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Positive Regulation Of Coagulation Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Wound Healing Regulation Of Humoral Immune Response Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Blood Coagulation Immune System Process Regulation Of Protein Metabolic Process Negative Regulation Of Coagulation Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Negative Regulation Of Wound Healing Regulation Of Peptidase Activity Platelet Degranulation Blood Coagulation Hemostasis Regulation Of Acute Inflammatory Response Positive Regulation Of Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Extracellular Matrix Disassembly Regulation Of Blood Coagulation Regulation Of Body Fluid Levels Proteolysis Wound Healing Negative Regulation Of Macrophage Chemotaxis Negative Regulation Of Complement Activation, Lectin Pathway Regulation Of Wound Healing Activation Of MAPK Activity Cell Activation Response To Wounding Cellular Homeostasis Mononuclear Cell Migration Regulation Of Intracellular Signal Transduction	Regulation Of Complement Activation Regulation Of Humoral Immune Response Regulation Of Acute Inflammatory Response Complement Activation, Classical Pathway Humoral Immune Response Mediated By Circulating Immunoglobulin Complement Activation Regulation Of Protein Processing Protein Activation Cascade Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Complement Activation, Alternative Pathway Humoral Immune Response Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Leukocyte Mediated Immunity Adaptive Immune Response Regulation Of Inflammatory Response Positive Regulation Of Immune Response Cytolysis Positive Regulation Of Activation Of Membrane Attack Complex Regulation Of Immune Response Positive Regulation Of Immune System Process Response To Stress Regulation Of Protein Metabolic Process Immune Response Regulation Of Immune System Process Defense Response Positive Regulation Of Apoptotic Cell Clearance Innate Immune Response Regulation Of Apoptotic Cell Clearance Positive Regulation Of Humoral Immune Response Positive Regulation Of Protein Processing Immune System Process Response To Stimulus Positive Regulation Of Phagocytosis Regulation Of Phagocytosis Organ Regeneration Complement Component C5a Signaling Pathway Regulation Of Metabolic Process Positive Regulation Of Endocytosis Positive Regulation Of Type IIa Hypersensitivity Protein Metabolic Process Cellular Chemical Homeostasis Positive Regulation Of Angiogenesis Positive Regulation Of Extracellular Matrix Constituent Secretion Negative Regulation Of Hepatocyte Proliferation Liver Regeneration Bradykinin Catabolic Process Cell Proliferation In Hindbrain Complement Receptor Mediated Signaling Pathway Cellular Homeostasis
Tagcloud ?		3t3 authentic binds block bovine cap cdcl2 complementation defect demonstrates eukaryotic influenza inserted m7gpppnm metallothionein mrnas mt nih papilloma produces product recognizes recombinant relieves strand transfection vector viral	autophosphorylation cleavage cleave cleaved convertases d4 endoproteolytic exclude furin greatly heterodimers ht29 idea igfs immunocytometry ir ir3 kda lovo participate posttranslational processed proprotein restore totally trypsin unable unprocessed unresponsive
Tagcloud (Difference) ?		3t3 authentic binds block bovine cap cdcl2 complementation defect demonstrates eukaryotic influenza inserted m7gpppnm metallothionein mrnas mt nih papilloma produces product recognizes recombinant relieves strand transfection vector viral	autophosphorylation cleavage cleave cleaved convertases d4 endoproteolytic exclude furin greatly heterodimers ht29 idea igfs immunocytometry ir ir3 kda lovo participate posttranslational processed proprotein restore totally trypsin unable unprocessed unresponsive
Tagcloud (Intersection) ?