CPB2 and PZP

Number of citations of the paper that reports this interaction (PMID 8662763)
4

Data Source:
HPRD (in vitro)

		CPB2	PZP
Gene Name		carboxypeptidase B2 (plasma)	pregnancy-zone protein
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Extracellular Vesicular Exosome	Extracellular Region Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Metallocarboxypeptidase Activity Zinc Ion Binding	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity
	Biological Process	Positive Regulation Of Extracellular Matrix Constituent Secretion Proteolysis Blood Coagulation Response To Heat Negative Regulation Of Plasminogen Activation Response To Drug Fibrinolysis Negative Regulation Of Fibrinolysis Cellular Response To Glucose Stimulus Liver Regeneration Negative Regulation Of Hepatocyte Proliferation	Female Pregnancy Negative Regulation Of Endopeptidase Activity
Pathways		Peptide hormone metabolism Metabolism of Angiotensinogen to Angiotensins
Drugs
Diseases
GWAS			Non-alcoholic fatty liver disease histology (AST) ( 20708005) Obesity-related traits ( 23251661)
Protein-Protein Interactions		7 interactors: A2M C5 F2 PLG PZP TINAG UBC	6 interactors: CPB2 KLK3 MMP2 MMP9 TGFB1 TGFB2
Entrez ID		1361	5858
HPRD ID		04374	07178
Ensembl ID		ENSG00000080618	ENSG00000126838
Uniprot IDs		Q96IY4
PDB IDs		3D66 3D67 3D68 3LMS
Enriched GO Terms of Interacting Partners?		Regulation Of Proteolysis Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Protein Processing Negative Regulation Of Fibrinolysis Regulation Of Fibrinolysis Blood Coagulation, Intrinsic Pathway Protein Activation Cascade Platelet Activation Leukocyte Migration Fibrinolysis Positive Regulation Of Blood Coagulation Negative Regulation Of Catalytic Activity Regulation Of Complement Activation Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Positive Regulation Of Coagulation Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Wound Healing Regulation Of Humoral Immune Response Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Blood Coagulation Immune System Process Regulation Of Protein Metabolic Process Negative Regulation Of Coagulation Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Negative Regulation Of Wound Healing Regulation Of Peptidase Activity Platelet Degranulation Blood Coagulation Hemostasis Regulation Of Acute Inflammatory Response Positive Regulation Of Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Extracellular Matrix Disassembly Regulation Of Blood Coagulation Regulation Of Body Fluid Levels Proteolysis Wound Healing Negative Regulation Of Macrophage Chemotaxis Negative Regulation Of Complement Activation, Lectin Pathway Regulation Of Wound Healing Activation Of MAPK Activity Cell Activation Response To Wounding Cellular Homeostasis Mononuclear Cell Migration Regulation Of Intracellular Signal Transduction	Extracellular Matrix Organization Extracellular Structure Organization Face Morphogenesis Regulation Of Extracellular Matrix Organization Head Morphogenesis Face Development Negative Regulation Of Macrophage Cytokine Production Body Morphogenesis Positive Regulation Of Epithelial Cell Migration Endoderm Development Extracellular Matrix Disassembly Blood Coagulation SMAD Protein Import Into Nucleus Hemostasis Negative Regulation Of Epithelial Cell Proliferation Pathway-restricted SMAD Protein Phosphorylation Regulation Of Fibrinolysis Regulation Of Epithelial Cell Migration Skeletal System Development Regulation Of Body Fluid Levels Wound Healing Response To Wounding Cell Morphogenesis Involved In Differentiation Female Pregnancy Fibrinolysis Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Epithelial To Mesenchymal Transition Skeletal System Morphogenesis Ossification Regulation Of Epithelial Cell Proliferation Endodermal Cell Differentiation Response To Hypoxia Positive Regulation Of Secretion Positive Regulation Of Cell Migration Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Salivary Gland Morphogenesis Positive Regulation Of Cell Motility Cell Morphogenesis Salivary Gland Development Positive Regulation Of Cellular Component Movement Response To Abiotic Stimulus Positive Regulation Of Locomotion Response To Progesterone Positive Regulation Of Stem Cell Differentiation Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Blood Coagulation Endoderm Formation SMAD Protein Signal Transduction Epithelial To Mesenchymal Transition Regulation Of Epithelial To Mesenchymal Transition
Tagcloud ?		3t3 authentic binds block bovine cap cdcl2 complementation defect demonstrates eukaryotic influenza inserted m7gpppnm metallothionein mrnas mt nih papilloma produces product recognizes recombinant relieves strand transfection vector viral	alt anthropometric apoc3 cms col13a1 consent corrections efcab4b infiltration iu nafld ncan obtaining parvb patatin pnpla3 rs2073080 rs2143571 rs2228603 rs2854117 rs343062 rs6487679 rs6591182 rs738409 samm50 sequenom snps transaminase triglyceride
Tagcloud (Difference) ?		3t3 authentic binds block bovine cap cdcl2 complementation defect demonstrates eukaryotic influenza inserted m7gpppnm metallothionein mrnas mt nih papilloma produces product recognizes recombinant relieves strand transfection vector viral	alt anthropometric apoc3 cms col13a1 consent corrections efcab4b infiltration iu nafld ncan obtaining parvb patatin pnpla3 rs2073080 rs2143571 rs2228603 rs2854117 rs343062 rs6487679 rs6591182 rs738409 samm50 sequenom snps transaminase triglyceride
Tagcloud (Intersection) ?