DIS3L2 and COPS6

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		DIS3L2	COPS6
Gene Name		DIS3 like 3-5 exoribonuclease 2	COP9 signalosome subunit 6
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasmic MRNA Processing Body Cytoplasm Polysome	Nucleoplasm Cytoplasm COP9 Signalosome Extracellular Vesicular Exosome
	Molecular Function	3'-5'-exoribonuclease Activity Magnesium Ion Binding Ribonuclease Activity Protein Binding Poly(U) RNA Binding	Protein Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Mitotic Nuclear Division Negative Regulation Of Cell Proliferation MiRNA Catabolic Process Stem Cell Maintenance Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' Cell Division Mitotic Sister Chromatid Separation RNA Phosphodiester Bond Hydrolysis RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Polyuridylation-dependent MRNA Catabolic Process	Cullin Deneddylation Viral Process
Pathways
Drugs
Diseases
GWAS		Height ( 23563607 19570815 18391951 20189936)
Protein-Protein Interactions		3 interactors: COPS6 FEZ1 VIM	84 interactors: ANXA1 ANXA7 BTBD2 C1orf174 C4orf17 CASP3 CASP6 CASP7 CASP8 CCDC106 CDH10 CDKN1A CDKN2C CHRNB1 COPS2 COPS3 COPS4 COPS5 COPS8 COX17 COX5A CRELD1 CUL1 CUL5 DIS3L2 DLEU1 EDN1 EIF3E EMD EP300 ERH FAU GPS1 HMOX2 JUN LAMA4 LPL MAP7D1 MAPK6 MAPKAPK3 MIF MNAT1 MYCBP NEDD8 NR3C1 ORAI2 PAEP PAFAH1B3 PBX2 PDZK1IP1 PFKL PHYHIP PMF1 PRKRA PSAP PSMD11 PTEN QTRT1 RAB27A RBX1 RFC5 ROGDI RPA2 RPL15 S100A10 SAT1 SERPINA5 SERPINB9 SLC2A1 SMN1 SNRPG STK40 STX5 SULT1E1 TDGF1 TK1 TP53 TP63 TRDMT1 TRIB3 VIM WIPI2 ZEB2 ZNF24
Entrez ID		129563	10980
HPRD ID		14619	16735
Ensembl ID		ENSG00000144535	ENSG00000168090
Uniprot IDs		Q8IYB7	Q7L5N1
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Neuron Projection Development Bergmann Glial Cell Differentiation Cullin Deneddylation Regulation Of Cell Projection Organization Protein Deneddylation Regulation Of Neuron Differentiation Viral Process Negative Regulation Of Macroautophagy Establishment Of Mitochondrion Localization Intermediate Filament Organization Lens Fiber Cell Development Regulation Of Neurogenesis Astrocyte Development Regulation Of Cell Development Muscle Filament Sliding Actin-myosin Filament Sliding Negative Regulation Of Autophagy Lens Fiber Cell Differentiation Mitochondrion Localization Intermediate Filament Cytoskeleton Organization Astrocyte Differentiation Intermediate Filament-based Process Actin-mediated Cell Contraction SMAD Protein Signal Transduction Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Actin Filament-based Movement Regulation Of Dendrite Morphogenesis Execution Phase Of Apoptosis	Cullin Deneddylation Protein Deneddylation Developmental Process Intrinsic Apoptotic Signaling Pathway Cellular Metabolic Process Anatomical Structure Development Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Regulation Of Cellular Protein Metabolic Process Apoptotic Process Regulation Of Catalytic Activity Tissue Development Mitotic Cell Cycle Programmed Cell Death Apoptotic Signaling Pathway Response To Stress Cell Death Catabolic Process Death Regulation Of Cell Proliferation Mitotic Cell Cycle Process Cellular Response To Stress Response To Abiotic Stimulus G1/S Transition Of Mitotic Cell Cycle Regulation Of Apoptotic Process Regulation Of Phosphorylation Response To Organic Cyclic Compound Cell Cycle Mitotic Cell Cycle Phase Transition Positive Regulation Of Cellular Metabolic Process Cell Cycle Phase Transition Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Cycle Organ Development Multicellular Organismal Development Epithelium Development Positive Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Cell Death Response To Stimulus Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Programmed Cell Death System Development Negative Regulation Of Cell Death Cellular Macromolecule Catabolic Process Response To Organic Substance Regulation Of Protein Kinase Activity Positive Regulation Of Cell Death
Tagcloud ?		biallelic degrades deleting dicer drosha enforced enu establishing exonuclease igf2 illustrated imprinting intense let lin28 mirna nephroblastoma noting opportunity pivotal predisposition recapitulates renewal rnases thirds wilms worth wt1 wtx	aiming aip alignment boar brms1 chordc1 clues csde1 csfv ddx5 domestic fever gnb2l1 hemorrhagic hspa8 interactive metap2 nav1 ncbi ns5a phf5a polr1c ppp2r3c psmc3 suvec swine tmed10 tmem70 y2h
Tagcloud (Difference) ?		biallelic degrades deleting dicer drosha enforced enu establishing exonuclease igf2 illustrated imprinting intense let lin28 mirna nephroblastoma noting opportunity pivotal predisposition recapitulates renewal rnases thirds wilms worth wt1 wtx	aiming aip alignment boar brms1 chordc1 clues csde1 csfv ddx5 domestic fever gnb2l1 hemorrhagic hspa8 interactive metap2 nav1 ncbi ns5a phf5a polr1c ppp2r3c psmc3 suvec swine tmed10 tmem70 y2h
Tagcloud (Intersection) ?