DIS3L2 and VIM

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		DIS3L2	VIM
Gene Name		DIS3 like 3-5 exoribonuclease 2	vimentin
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasmic MRNA Processing Body Cytoplasm Polysome	Cytoplasm Peroxisome Cytosol Cytoskeleton Intermediate Filament Plasma Membrane Focal Adhesion Cell Leading Edge Neuron Projection Intermediate Filament Cytoskeleton Extracellular Vesicular Exosome
	Molecular Function	3'-5'-exoribonuclease Activity Magnesium Ion Binding Ribonuclease Activity Protein Binding Poly(U) RNA Binding	Glycoprotein Binding Double-stranded RNA Binding Structural Constituent Of Cytoskeleton Structural Constituent Of Eye Lens Protein Binding Protein C-terminus Binding Identical Protein Binding Scaffold Protein Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Mitotic Nuclear Division Negative Regulation Of Cell Proliferation MiRNA Catabolic Process Stem Cell Maintenance Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' Cell Division Mitotic Sister Chromatid Separation RNA Phosphodiester Bond Hydrolysis RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Polyuridylation-dependent MRNA Catabolic Process	Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Movement Of Cell Or Subcellular Component Positive Regulation Of Gene Expression Negative Regulation Of Neuron Projection Development Astrocyte Development Viral Process Muscle Filament Sliding Intermediate Filament Organization Bergmann Glial Cell Differentiation SMAD Protein Signal Transduction Lens Fiber Cell Development
Pathways			Apoptotic cleavage of cellular proteins Striated Muscle Contraction Programmed Cell Death Apoptotic execution phase Caspase-mediated cleavage of cytoskeletal proteins
Drugs
Diseases
GWAS		Height ( 23563607 19570815 18391951 20189936)
Protein-Protein Interactions		3 interactors: COPS6 FEZ1 VIM	140 interactors: ABLIM1 AKT1 ALS2CR11 ANKRD35 ANXA7 APIP APLP1 APP ARMCX2 ATN1 BFSP1 BHLHE40 BRD1 CAMK2D CAPN1 CASP3 CASP6 CASP7 CASP8 CASP9 CDH5 CDK1 CDKN1A CHD3 COPS6 CRCT1 CREB1 CRMP1 CWF19L2 DCTN1 DEFB1 DGCR14 DIS3L2 DNM1L DPPA4 DSP DYNLL1 EIF3I FABP4 FAM107A FAM118B FUBP1 GADD45A GFAP GOPC GRB2 GSK3B HABP4 HAP1 HMG20B HTRA2 ING5 ITGB4 IVNS1ABP KARS KAT7 KIAA0408 KIAA1377 KIF15 KRT20 LOR LRIF1 MAFG MAN2A2 MEN1 MICAL1 MRPL44 NEFL NFATC2 NIF3L1 NME2 NOC4L NR1H2 NUP85 OSBP2 PAK2 PDLIM1 PIAS4 PKD1 PKN1 PKP1 PLA2G2A PLA2G4A PLEC PNMA5 POLR1C PPHLN1 PPL PRKACA PRPH PSMA1 PSMD7 PSME1 PUF60 RAB8B RABAC1 RAD51 RBM48 RIBC2 ROCK1 RPA1 SDCCAG3 SERBP1 SETDB1 SH3GL1 SH3GL3 SH3YL1 SIRT6 SLC25A6 SLC27A6 SMAD3 SRRT STX1A SUMO2 SUMO3 SYN1 TAB2 TCHP TNFRSF14 TNNT1 TRIM28 TRIM29 TRIOBP TSC22D1 TTR TUBGCP4 TXLNB TXN TXN2 UPP1 UPP2 UROD UTP14A WBP11 XRCC4 YAE1D1 YWHAE YWHAZ ZHX1 ZNF384
Entrez ID		129563	7431
HPRD ID		14619	01899
Ensembl ID		ENSG00000144535	ENSG00000026025
Uniprot IDs		Q8IYB7	P08670
PDB IDs			1GK4 1GK6 1GK7 3G1E 3KLT 3S4R 3SSU 3SWK 3TRT 3UF1
Enriched GO Terms of Interacting Partners?		Regulation Of Neuron Projection Development Bergmann Glial Cell Differentiation Cullin Deneddylation Regulation Of Cell Projection Organization Protein Deneddylation Regulation Of Neuron Differentiation Viral Process Negative Regulation Of Macroautophagy Establishment Of Mitochondrion Localization Intermediate Filament Organization Lens Fiber Cell Development Regulation Of Neurogenesis Astrocyte Development Regulation Of Cell Development Muscle Filament Sliding Actin-myosin Filament Sliding Negative Regulation Of Autophagy Lens Fiber Cell Differentiation Mitochondrion Localization Intermediate Filament Cytoskeleton Organization Astrocyte Differentiation Intermediate Filament-based Process Actin-mediated Cell Contraction SMAD Protein Signal Transduction Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Actin Filament-based Movement Regulation Of Dendrite Morphogenesis Execution Phase Of Apoptosis	Programmed Cell Death Apoptotic Process Cell Death Death Execution Phase Of Apoptosis Regulation Of Cell Death Response To Abiotic Stimulus Regulation Of Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Response To Stress Positive Regulation Of Proteolysis Regulation Of Cellular Localization Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Proteolysis Regulation Of Cellular Process Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Establishment Of Protein Localization Positive Regulation Of Cell Death Nitrogen Compound Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Localization Organelle Organization Cell Cycle Process Cellular Response To Stress Positive Regulation Of Apoptotic Process Negative Regulation Of Cell Death Regulation Of Protein Metabolic Process Positive Regulation Of Apoptotic Signaling Pathway Gene Expression Immune System Process Regulation Of Intracellular Transport Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cell Cycle Anatomical Structure Development Positive Regulation Of Signal Transduction Mitotic Cell Cycle Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Programmed Cell Death Cellular Process Apoptotic Signaling Pathway Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Viral Process Intrinsic Apoptotic Signaling Pathway
Tagcloud ?		biallelic degrades deleting dicer drosha enforced enu establishing exonuclease igf2 illustrated imprinting intense let lin28 mirna nephroblastoma noting opportunity pivotal predisposition recapitulates renewal rnases thirds wilms worth wt1 wtx	10p13 17q21 5q15 6p24 australian british cl cleft crtl1 d1s58 d1s65 der excluded f13a1 flank inheritance linkage lip lod multipoint palate rara syndromic theta unrelated van vws woude z
Tagcloud (Difference) ?		biallelic degrades deleting dicer drosha enforced enu establishing exonuclease igf2 illustrated imprinting intense let lin28 mirna nephroblastoma noting opportunity pivotal predisposition recapitulates renewal rnases thirds wilms worth wt1 wtx	10p13 17q21 5q15 6p24 australian british cl cleft crtl1 d1s58 d1s65 der excluded f13a1 flank inheritance linkage lip lod multipoint palate rara syndromic theta unrelated van vws woude z
Tagcloud (Intersection) ?