DIS3L2

Description		DIS3 like 3'-5' exoribonuclease 2
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GO Annotations	Cellular Component	P-body Cytoplasm
	Molecular Function	3'-5'-RNA Exonuclease Activity Magnesium Ion Binding RNA Binding Nuclease Activity Exonuclease Activity RNA Nuclease Activity Protein Binding Poly(U) RNA Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Mitotic Cell Cycle Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Negative Regulation Of Cell Population Proliferation MiRNA Catabolic Process Stem Cell Population Maintenance Cell Division Mitotic Sister Chromatid Separation Polyuridylation-dependent MRNA Catabolic Process
Pathways		Z-decay: degradation of maternal mRNAs by zygotically expressed factors
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Chronic back pain ( 30261039) Height ( 19570815 34270706 31562340 28552196 25429064 25282103 23563607 20189936 18391951) Hip circumference adjusted for BMI ( 25673412 34021172) Refractive error ( 32231278) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500 34021172)
Interacting Genes		3 interacting genes: COPS6 FEZ1 VIM
Entrez ID		129563
HPRD ID		14619
Ensembl ID		ENSG00000144535
Uniprot IDs		Q8IYB7
PDB IDs		8E27 8E28 8E29 8E2A
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Anterograde Axonal Transport Of Mitochondrion Lens Fiber Cell Development Axon Regulation Of Neuron Projection Development Keratin Filament Binding Cellular Response To Muramyl Dipeptide Bergmann Glial Cell Differentiation Regulation Of Organelle Transport Along Microtubule Negative Regulation Of Autophagosome Assembly Protein Deneddylation Metal-dependent Deubiquitinase Activity Neuron Projection Development Regulation Of Plasma Membrane Bounded Cell Projection Organization Astrocyte Development Structural Constituent Of Eye Lens Response To Muramyl Dipeptide Positive Regulation Of Collagen Biosynthetic Process Regulation Of Protein Neddylation Protein Neddylation Regulation Of Cell Projection Organization Negative Regulation Of Cellular Component Organization Astrocyte Differentiation Gamma-tubulin Binding Establishment Of Mitochondrion Localization COP9 Signalosome Negative Regulation Of Macroautophagy Regulation Of Collagen Biosynthetic Process Regulation Of Collagen Metabolic Process Intermediate Filament Cytoskeleton Plasma Membrane Bounded Cell Projection Organization Regulation Of Autophagosome Assembly Protein Kinase C Binding Regulation Of Microtubule-based Movement Mitochondrion Localization
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