BMP1 and LAMC2

Number of citations: 0 (PubMedID 10806203)
Data Source: HPRD (in vitro, in vivo)

		BMP1	LAMC2
Name		bone morphogenetic protein 1	laminin subunit gamma 2
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Apparatus Vesicle	Extracellular Region Basement Membrane Laminin-2 Complex Extracellular Space Cell Cortex Extracellular Matrix Perinuclear Region Of Cytoplasm
	Molecular Function	Metalloendopeptidase Activity Serine-type Endopeptidase Activity Cytokine Activity Calcium Ion Binding Protein Binding Growth Factor Activity Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Identical Protein Binding Metal Ion Binding	Extracellular Matrix Structural Constituent Heparin Binding
	Biological Process	Skeletal System Development Cartilage Condensation Ossification Proteolysis Signal Transduction Dorsal/ventral Pattern Formation Protein Processing Cell Differentiation Collagen Fibril Organization Cartilage Development Positive Regulation Of Cartilage Development	Cell Adhesion Positive Regulation Of Cell Population Proliferation Epidermis Development Positive Regulation Of Cell Migration
Pathways		Degradation of the extracellular matrix Degradation of the extracellular matrix Collagen biosynthesis and modifying enzymes Anchoring fibril formation Crosslinking of collagen fibrils	Degradation of the extracellular matrix Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Anchoring fibril formation Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions Type I hemidesmosome assembly MET activates PTK2 signaling Attachment of bacteria to epithelial cells Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC) Developmental Lineage of Pancreatic Ductal Cells
Diseases		None	Epidermolysis bullosa, junctional, including: Epidermolysis bullosa, junctional, Herlitz type (JEB-H); Epidermolysis bullosa, junctional, non-Herlitz type (JEB-nH); Epidermolysis bullosa, junctional, with pyloric atresia (JEB-PA)
GWAS		Coronary artery disease ( 29212778 ) Hypertriglyceridemia ( 23505323 ) Myocardial infarction ( 33532862 ) Waist-to-hip ratio adjusted for BMI ( 28552196 )	Acne (severe) ( 30542056 ) Blood protein levels ( 30072576 ) Clozapine-induced agranulocytosis ( 25187353 ) HDL cholesterol ( 21347282 ) Low density lipoprotein cholesterol levels ( 32154731 ) Morning person ( 30696823 ) Systemic lupus erythematosus ( 21408207 )
Novel Interactors		4 novel interactors: CLIP2 CST7 DST PTPRZ1	1 novel interactors: SCAP
Interacting Genes		14 interacting genes: ADRA1A CHRD COL1A1 COL5A1 COL5A2 COL7A1 GEM HSPG2 LAMA3 LAMB3 LAMC2 TP53 TWSG1 YLPM1	7 interacting genes: BMP1 COL7A1 CSF1R FBLN2 LAMB3 NID1 SLA2
Entrez ID		649	3918
HPRD ID		00209	01031
Ensembl ID		ENSG00000168487	ENSG00000058085
Uniprot IDs		P13497	Q13753
PDB IDs		3EDG 3EDH 6BSL 6BSM 6BTN 6BTO 6BTP 6BTQ	Not available
GO Terms Enriched among Interactors		Basement Membrane Extracellular Matrix Extracellular Matrix Structural Constituent Extracellular Matrix Structural Constituent Conferring Tensile Strength Fibrillar Collagen Trimer Extracellular Region Tissue Development Collagen Trimer Collagen Type V Trimer Negative Regulation Of Endodermal Cell Differentiation Laminin-5 Complex Endodermal Cell Differentiation Collagen Type XI Trimer Epidermis Development Hemidesmosome Assembly Integrin Binding Skin Development Hemidesmosome Collagen Fibril Organization Regulation Of Developmental Process Platelet-derived Growth Factor Binding Collagen Biosynthetic Process Cell Adhesion Protease Binding Response To Xenobiotic Stimulus Microtubule Plus-end Binding Endoplasmic Reticulum Lumen Developmental Process Microtubule Plus-end Negative Regulation Of Developmental Process Animal Organ Development Anatomical Structure Morphogenesis System Development Extracellular Space Negative Regulation Of Cell Differentiation Heparin Binding Regulation Of Cell Differentiation Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cell-substrate Junction Assembly Cell Cortex Structural Molecule Activity Cell-substrate Junction Organization Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Negative Regulation Of Heart Rate Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Regulation Of Cell Population Proliferation Cellular Response To Vitamin E Skeletal System Development Integrin Biosynthetic Process Collagen Type VII Trimer Regulation Of Myelination	Extracellular Matrix Basement Membrane Extracellular Matrix Structural Constituent Extracellular Matrix Binding Endodermal Cell Differentiation Collagen Type VII Trimer SREBP-SCAP Complex CSF1-CSF1R Complex Macrophage Colony-stimulating Factor Receptor Activity Response To Vitamin B3 Extracellular Region