BMP1 and TWSG1

Number of citations of the paper that reports this interaction (PubMedID 11260715)
0

Data Source:
HPRD (in vivo)

		BMP1	TWSG1
Description		bone morphogenetic protein 1	twisted gastrulation BMP signaling modulator 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Apparatus Vesicle	Extracellular Region Extracellular Space
	Molecular Function	Metalloendopeptidase Activity Serine-type Endopeptidase Activity Cytokine Activity Calcium Ion Binding Protein Binding Growth Factor Activity Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Identical Protein Binding Metal Ion Binding	Protein Binding Heparin Binding Transforming Growth Factor Beta Binding
	Biological Process	Skeletal System Development Cartilage Condensation Ossification Proteolysis Signal Transduction Dorsal/ventral Pattern Formation Protein Processing Cell Differentiation Collagen Fibril Organization Cartilage Development Positive Regulation Of Cartilage Development	Ossification Mesoderm Formation Negative Regulation Of Cytokine Production Chondrocyte Differentiation Salivary Gland Morphogenesis Tissue Development Hemopoiesis BMP Signaling Pathway Regulation Of BMP Signaling Pathway Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of BMP Signaling Pathway Negative Regulation Of BMP Signaling Pathway Forebrain Development Camera-type Eye Development Negative Regulation Of Osteoblast Differentiation Positive Regulation Of SMAD Protein Signal Transduction Negative Regulation Of CD4-positive, Alpha-beta T Cell Activation Negative Regulation Of CD4-positive, Alpha-beta T Cell Proliferation
Pathways		Degradation of the extracellular matrix Degradation of the extracellular matrix Collagen biosynthesis and modifying enzymes Anchoring fibril formation Crosslinking of collagen fibrils
Drugs
Diseases
GWAS		Coronary artery disease ( 29212778) Hypertriglyceridemia ( 23505323) Myocardial infarction ( 33532862) Waist-to-hip ratio adjusted for BMI ( 28552196)	Dental caries ( 23064961)
Interacting Genes		14 interacting genes: ADRA1A CHRD COL1A1 COL5A1 COL5A2 COL7A1 GEM HSPG2 LAMA3 LAMB3 LAMC2 TP53 TWSG1 YLPM1	10 interacting genes: BMP1 BMP4 CHRD FAM209A FNDC9 GJA8 GPRC5D LRRC4C SGTA TNS2
Entrez ID		649	57045
HPRD ID		00209	05443
Ensembl ID		ENSG00000168487	ENSG00000128791
Uniprot IDs		P13497	Q9GZX9
PDB IDs		3EDG 3EDH 6BSL 6BSM 6BTN 6BTO 6BTP 6BTQ	8BWA 8BWD 8BWI 8BWL 8BWM 8BWN
Enriched GO Terms of Interacting Partners?		Basement Membrane Extracellular Matrix Extracellular Matrix Structural Constituent Extracellular Matrix Structural Constituent Conferring Tensile Strength Fibrillar Collagen Trimer Extracellular Region Tissue Development Collagen Trimer Collagen Type V Trimer Negative Regulation Of Endodermal Cell Differentiation Laminin-5 Complex Endodermal Cell Differentiation Collagen Type XI Trimer Epidermis Development Hemidesmosome Assembly Integrin Binding Skin Development Hemidesmosome Collagen Fibril Organization Regulation Of Developmental Process Platelet-derived Growth Factor Binding Collagen Biosynthetic Process Cell Adhesion Protease Binding Response To Xenobiotic Stimulus Microtubule Plus-end Binding Endoplasmic Reticulum Lumen Developmental Process Microtubule Plus-end Negative Regulation Of Developmental Process Animal Organ Development Anatomical Structure Morphogenesis System Development Extracellular Space Negative Regulation Of Cell Differentiation Heparin Binding Regulation Of Cell Differentiation Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cell-substrate Junction Assembly Cell Cortex Structural Molecule Activity Cell-substrate Junction Organization Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Negative Regulation Of Heart Rate Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Regulation Of Cell Population Proliferation Cellular Response To Vitamin E Skeletal System Development Integrin Biosynthetic Process Collagen Type VII Trimer Regulation Of Myelination	Dorsal/ventral Pattern Formation Positive Regulation Of Cartilage Development Skeletal System Development Regionalization Negative Regulation Of Metanephric Comma-shaped Body Morphogenesis Bud Dilation Involved In Lung Branching Apoptotic Process Involved In Endocardial Cushion Morphogenesis Negative Regulation Of Mesenchymal Cell Proliferation Involved In Ureter Development Intermediate Mesodermal Cell Differentiation Regulation Of Mesenchymal Cell Proliferation Negative Regulation Of Metanephric S-shaped Body Morphogenesis Positive Regulation Of Cardiac Muscle Fiber Development Negative Regulation Of Glomerulus Development Negative Regulation Of BMP Signaling Pathway Regulation Of Cartilage Development Positive Regulation Of Primary MiRNA Processing Tendon Cell Differentiation Negative Regulation Of Branching Involved In Ureteric Bud Morphogenesis Camera-type Eye Development BMP Signaling Pathway Positive Regulation Of Branching Involved In Lung Morphogenesis TRC Complex Pattern Specification Process Growth Factor Activity Cartilage Development Ossification Apoptotic Process Involved In Heart Morphogenesis Regulation Of Osteoblast Differentiation Positive Regulation Of MiRNA Processing Negative Regulation Of Glomerular Mesangial Cell Proliferation Nephric Duct Formation Bronchus Development Positive Regulation Of Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Deltoid Tuberosity Development Epithelial Cell Proliferation Involved In Lung Morphogenesis Cardiac Jelly Development Eye Development Negative Regulation Of Immature T Cell Proliferation Prostate Gland Morphogenesis Epithelial-mesenchymal Cell Signaling Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Branching Involved In Lung Morphogenesis Telencephalon Regionalization Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Regulation Of Branching Involved In Prostate Gland Morphogenesis Glomerular Capillary Formation Pericyte Cell Differentiation Specification Of Animal Organ Position Regulation Of BMP Signaling Pathway Trachea Development
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