BMP1 and TWSG1

Number of citations of the paper that reports this interaction (PMID 11260715)
41

Data Source:
HPRD (in vivo)

		BMP1	TWSG1
Gene Name		bone morphogenetic protein 1	twisted gastrulation BMP signaling modulator 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Golgi Apparatus Membrane-bounded Vesicle	Extracellular Space Extracellular Vesicular Exosome
	Molecular Function	Metalloendopeptidase Activity Cytokine Activity Calcium Ion Binding Growth Factor Activity Peptidase Activity Metallopeptidase Activity Zinc Ion Binding
	Biological Process	Skeletal System Development Cartilage Condensation Ossification Proteolysis Multicellular Organismal Development Extracellular Matrix Disassembly Cell Differentiation Extracellular Matrix Organization Lipoprotein Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Cartilage Development	Ossification Mesoderm Formation Salivary Gland Morphogenesis Hemopoiesis Cell Differentiation BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Negative Regulation Of BMP Signaling Pathway Forebrain Development Camera-type Eye Development Negative Regulation Of Osteoblast Differentiation
Pathways		Collagen formation Crosslinking of collagen fibrils Anchoring fibril formation Collagen biosynthesis and modifying enzymes Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures
Drugs
Diseases
GWAS		Hypertriglyceridemia ( 23505323)	Dental caries ( 23064961)
Protein-Protein Interactions		14 interactors: ADRA1A CHRD COL1A1 COL5A1 COL5A2 COL7A1 GEM HSPG2 LAMA3 LAMB3 LAMC2 TP53 TWSG1 YLPM1	4 interactors: BMP1 BMP4 CHRD SGTA
Entrez ID		649	57045
HPRD ID		00209	05443
Ensembl ID		ENSG00000168487	ENSG00000128791
Uniprot IDs		P13497	Q9GZX9
PDB IDs		3EDG 3EDH
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Gastrulation Tissue Development Formation Of Primary Germ Layer Embryonic Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Hemidesmosome Assembly Collagen Catabolic Process Embryo Development Anatomical Structure Morphogenesis Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Anatomical Structure Development Ossification Negative Regulation Of Endodermal Cell Differentiation Epithelium Development Developmental Process Endodermal Cell Differentiation Cell Differentiation Cell-substrate Junction Assembly Multicellular Organismal Development Endoderm Formation Collagen Fibril Organization Epidermis Development Endoderm Development Collagen Biosynthetic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cell Adhesion Regulation Of Embryonic Development Negative Regulation Of Cell Differentiation Head Development Organ Development Negative Regulation Of Embryonic Development Regulation Of Cell Differentiation Organ Morphogenesis Cell Junction Assembly Regulation Of Gastrulation Cartilage Development Involved In Endochondral Bone Morphogenesis Skeletal System Development Endochondral Ossification Skin Development Negative Regulation Of BMP Signaling Pathway Response To External Stimulus Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Connective Tissue Development Negative Regulation Of Osteoblast Differentiation Cellular Response To Amino Acid Stimulus	Ossification Positive Regulation Of Cartilage Development Regulation Of Mesenchymal Cell Proliferation Skeletal System Development BMP Signaling Pathway Regulation Of BMP Signaling Pathway Mesoderm Formation Regulation Of Cartilage Development Mesoderm Morphogenesis Regulation Of Stem Cell Proliferation Dorsal/ventral Pattern Formation Negative Regulation Of Metanephric S-shaped Body Morphogenesis Negative Regulation Of Metanephric Comma-shaped Body Morphogenesis BMP Signaling Pathway Involved In Spinal Cord Dorsal/ventral Patterning Mesenchymal Cell Proliferation Involved In Ureter Development Ureter Epithelial Cell Differentiation Negative Regulation Of Mesenchymal Cell Proliferation Involved In Ureter Development Negative Regulation Of Cell Proliferation Involved In Heart Morphogenesis Pulmonary Artery Endothelial Tube Morphogenesis BMP Signaling Pathway Involved In Renal System Segmentation BMP Signaling Pathway Involved In Ureter Morphogenesis Negative Regulation Of Branch Elongation Involved In Ureteric Bud Branching By BMP Signaling Pathway Specification Of Ureteric Bud Anterior/posterior Symmetry By BMP Signaling Pathway Positive Regulation Of Cardiac Muscle Fiber Development Bud Dilation Involved In Lung Branching Epithelial Cell Proliferation Involved In Lung Morphogenesis BMP Signaling Pathway Involved In Nephric Duct Formation Intermediate Mesodermal Cell Differentiation Regulation Of Osteoblast Differentiation Formation Of Primary Germ Layer Osteoblast Differentiation Mesoderm Development Intermediate Mesoderm Development Gastrulation Neural Tube Development Cartilage Development Regulation Of Ossification Negative Regulation Of Glomerular Mesangial Cell Proliferation Ureter Urothelium Development Mesenchymal Cell Proliferation Involved In Ureteric Bud Development Cloacal Septation Negative Regulation Of Glomerulus Development Mesodermal Cell Fate Determination BMP Signaling Pathway Involved In Heart Induction Deltoid Tuberosity Development Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Connective Tissue Development Ureter Morphogenesis Ureter Smooth Muscle Cell Differentiation Regulation Of Branch Elongation Involved In Ureteric Bud Branching
Tagcloud ?		augment c1r c1s cub embryogenesis fli1a founding gata1 hbbe1 hematopoiesis hierarchy injecting maternally mesoderm morphants morphogenetic morpholino mount mpo myelomonocytic oligonucleotide plastin primitive pu scube scube1 uegf zebrafish	acted anomaly bmp bmp2 concert dams e11 e9 embryonal expressivity forebrain gastrulation gavage geometric holoprosencephaly hpe manifested microct midface midline morphometric narrowing ntd overt p19 penetrance predisposing teratogenesis twisted
Tagcloud (Difference) ?		augment c1r c1s cub embryogenesis fli1a founding gata1 hbbe1 hematopoiesis hierarchy injecting maternally mesoderm morphants morphogenetic morpholino mount mpo myelomonocytic oligonucleotide plastin primitive pu scube scube1 uegf zebrafish	acted anomaly bmp2 concert dams e11 e9 embryonal expressivity forebrain gastrulation gavage geometric holoprosencephaly hpe manifested microct midface midline morphometric narrowing ntd overt p19 penetrance predisposing teratogenesis twisted
Tagcloud (Intersection) ?		bmp