BMP1 and COL1A1

Number of citations of the paper that reports this interaction (PubMedID 11283002)
0

Data Source:
HPRD (in vivo)

		BMP1	COL1A1
Description		bone morphogenetic protein 1	collagen type I alpha 1 chain
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Apparatus Vesicle	Extracellular Region Collagen Trimer Fibrillar Collagen Trimer Collagen Type I Trimer Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Secretory Granule Extracellular Matrix
	Molecular Function	Metalloendopeptidase Activity Serine-type Endopeptidase Activity Cytokine Activity Calcium Ion Binding Protein Binding Growth Factor Activity Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Identical Protein Binding Metal Ion Binding	Protease Binding Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Identical Protein Binding Metal Ion Binding Platelet-derived Growth Factor Binding
	Biological Process	Skeletal System Development Cartilage Condensation Ossification Proteolysis Signal Transduction Dorsal/ventral Pattern Formation Protein Processing Cell Differentiation Collagen Fibril Organization Cartilage Development Positive Regulation Of Cartilage Development	Skeletal System Development Ossification Blood Vessel Development Osteoblast Differentiation Intramembranous Ossification Endochondral Ossification Response To Nutrient Visual Perception Sensory Perception Of Sound Response To Xenobiotic Stimulus Response To Mechanical Stimulus Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Cell-substrate Adhesion Protein Transport Collagen Fibril Organization Positive Regulation Of Cell Migration Response To Nutrient Levels Response To Estradiol Response To Insulin Collagen Biosynthetic Process Protein Localization To Nucleus Tooth Mineralization Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Response To Hydrogen Peroxide Response To Peptide Hormone Skin Development Skin Morphogenesis Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of DNA-templated Transcription Animal Organ Development Response To Steroid Hormone Skeletal System Morphogenesis Embryonic Skeletal System Development System Development Response To CAMP Response To Hyperoxia Face Morphogenesis Bone Trabecula Formation Cartilage Development Involved In Endochondral Bone Morphogenesis Cellular Response To Amino Acid Stimulus Cellular Response To Mechanical Stimulus Cellular Response To Retinoic Acid Cellular Response To Vitamin E Cellular Response To Glucose Stimulus Cellular Response To Tumor Necrosis Factor Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Canonical Wnt Signaling Pathway Response To Fluoride Cellular Response To Fluoride
Pathways		Degradation of the extracellular matrix Degradation of the extracellular matrix Collagen biosynthesis and modifying enzymes Anchoring fibril formation Crosslinking of collagen fibrils	GPVI-mediated activation cascade Collagen degradation Collagen degradation Fibronectin matrix formation Collagen biosynthesis and modifying enzymes Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Assembly of collagen fibrils and other multimeric structures Cell surface interactions at the vascular wall Integrin cell surface interactions Integrin cell surface interactions Anchoring fibril formation Crosslinking of collagen fibrils Syndecan interactions Non-integrin membrane-ECM interactions ECM proteoglycans ECM proteoglycans Scavenging by Class A Receptors GP1b-IX-V activation signalling Platelet Adhesion to exposed collagen Platelet Adhesion to exposed collagen Platelet Aggregation (Plug Formation) MET activates PTK2 signaling RUNX2 regulates osteoblast differentiation Collagen chain trimerization Enhanced cleavage of VWF variant by ADAMTS13 Enhanced binding of GP1BA variant to VWF multimer:collagen Defective VWF cleavage by ADAMTS13 variant Defective VWF binding to collagen type I Defective binding of VWF variant to GPIb:IX:V Developmental Lineage of Pancreatic Ductal Cells
Drugs			Collagenase clostridium histolyticum Halofuginone Clove oil Vonicog alfa Von Willebrand factor human
Diseases			Osteogenesis imperfecta Ehlers-Danlos syndrome (EDS), including: EDS classical type (EDS1/2); EDS hypermobility type (EDS3); EDS vascular type (EDS4); EDS kyphoscoliosis type (EDS6); EDS arthrochalasia type (EDS7A/7B); EDS dermatospraxis type (EDS7C); EDS autosomal recessive cardiac valvular form (EDSCV); EDS musculocontractural type (EDSMC); EDS progeroid form (EDSP); Tenascin-X deficiency (TNXD); Brittle cornea syndrome (EDS6B); EDS-like spondylocheiro dysplasia (SCD-EDS) Infantile cortical hyperostosis; Caffey disease
GWAS		Coronary artery disease ( 29212778) Hypertriglyceridemia ( 23505323) Myocardial infarction ( 33532862) Waist-to-hip ratio adjusted for BMI ( 28552196)	Blood cell traits (multivariate analysis) ( 31080455) Breast cancer ( 17903305) Heel bone mineral density ( 30598549) Keratoconus ( 33649486) Response to taxane treatment (docetaxel) ( 23006423)
Interacting Genes		14 interacting genes: ADRA1A CHRD COL1A1 COL5A1 COL5A2 COL7A1 GEM HSPG2 LAMA3 LAMB3 LAMC2 TP53 TWSG1 YLPM1	44 interacting genes: ATP13A2 BARD1 BGN BMP1 BRCA1 CAPN1 CD36 CD44 CD93 CDC42 COL18A1 COL7A1 DCN DDR2 FGF7 FN1 HTRA1 IGFBP3 ITGA2 ITGA5 KEAP1 LAIR1 MAG MATN2 MCPH1 MMP2 MMP9 NID1 NID2 P4HB PAK1 PDGFA PDGFB PKD1 PRELP SPARC TGFBI TGM2 THBS1 TMPRSS6 TNFAIP3 TXN UBC VWF
Entrez ID		649	1277
HPRD ID		00209	00362
Ensembl ID		ENSG00000168487	ENSG00000108821
Uniprot IDs		P13497	P02452
PDB IDs		3EDG 3EDH 6BSL 6BSM 6BTN 6BTO 6BTP 6BTQ	1Q7D 2LLP 3EJH 3GXE 5CTD 5CTI 5CVA 5CVB 5K31 5OU8 5OU9 7E7B 7E7D
Enriched GO Terms of Interacting Partners?		Basement Membrane Extracellular Matrix Extracellular Matrix Structural Constituent Extracellular Matrix Structural Constituent Conferring Tensile Strength Fibrillar Collagen Trimer Extracellular Region Tissue Development Collagen Trimer Collagen Type V Trimer Negative Regulation Of Endodermal Cell Differentiation Laminin-5 Complex Endodermal Cell Differentiation Collagen Type XI Trimer Epidermis Development Hemidesmosome Assembly Integrin Binding Skin Development Hemidesmosome Collagen Fibril Organization Regulation Of Developmental Process Platelet-derived Growth Factor Binding Collagen Biosynthetic Process Cell Adhesion Protease Binding Response To Xenobiotic Stimulus Microtubule Plus-end Binding Endoplasmic Reticulum Lumen Developmental Process Microtubule Plus-end Negative Regulation Of Developmental Process Animal Organ Development Anatomical Structure Morphogenesis System Development Extracellular Space Negative Regulation Of Cell Differentiation Heparin Binding Regulation Of Cell Differentiation Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cell-substrate Junction Assembly Cell Cortex Structural Molecule Activity Cell-substrate Junction Organization Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Negative Regulation Of Heart Rate Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Regulation Of Cell Population Proliferation Cellular Response To Vitamin E Skeletal System Development Integrin Biosynthetic Process Collagen Type VII Trimer Regulation Of Myelination	Collagen Binding Extracellular Matrix Extracellular Region Extracellular Matrix Structural Constituent Extracellular Space Positive Regulation Of Cell Migration Basement Membrane Positive Regulation Of Cell Motility Extracellular Matrix Binding Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Locomotion Cell Adhesion Positive Regulation Of Cell Communication Positive Regulation Of Signal Transduction Extracellular Structure Organization Extracellular Matrix Organization Regulation Of Cell Migration Regulation Of Cell Motility Response To Wounding Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Intracellular Signal Transduction Positive Regulation Of Signaling Regulation Of Locomotion Developmental Process Cell-substrate Adhesion Regulation Of Signal Transduction Regulation Of Cell Adhesion Positive Regulation Of Intracellular Signal Transduction Cell-matrix Adhesion Platelet Alpha Granule Lumen Regulation Of Cell Communication Regulation Of Anatomical Structure Morphogenesis Regulation Of Cellular Component Organization Endodermal Cell Differentiation Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Cell-substrate Adhesion Extracellular Exosome Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Angiogenesis Regulation Of Cell-substrate Adhesion Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Regulation Of Signaling Integrin Binding Regulation Of Developmental Process Positive Regulation Of Cell Population Proliferation Positive Regulation Of Cell Adhesion Cell Surface Regulation Of MAPK Cascade Endoplasmic Reticulum Lumen Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
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