SETD1A

Gene Name		SET domain containing 1A
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nuclear Speck Histone Methyltransferase Complex Set1C/COMPASS Complex
	Molecular Function	Nucleotide Binding RNA Binding Protein Binding Histone Methyltransferase Activity (H3-K4 Specific)
	Biological Process	Chromatin Organization Transcription, DNA-templated Regulation Of Transcription, DNA-templated Stem Cell Maintenance Histone H3-K4 Methylation Positive Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Stem Cell Proliferation
Pathways		Chromatin modifying enzymes Chromatin organization PKMTs methylate histone lysines
Drugs
Diseases
GWAS
Protein-protein Interactions		7 interactors: DPY30 EP300 HIST1H3A HIST2H3C LBP TP53 WDR5
Entrez ID		9739
HPRD ID		13795
Ensembl ID		ENSG00000099381
Uniprot IDs		O15047
PDB IDs		3S8S 3UVN 4EWR
Enriched GO Terms of Interacting Partners?		Chromatin Organization Chromosome Organization Methylation DNA Methylation On Cytosine Chromatin Silencing At RDNA Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Histone H3-K4 Methylation Peptidyl-lysine Modification Chromatin Silencing Gene Expression Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Protein Deacetylation Histone H4 Acetylation DNA Methylation Negative Regulation Of Transcription, DNA-templated Histone Modification Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Blood Coagulation Hemostasis Negative Regulation Of Gene Expression, Epigenetic Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Somitogenesis Regulation Of RNA Metabolic Process DNA Modification Negative Regulation Of Gene Expression Histone H2B Acetylation Nucleobase-containing Compound Metabolic Process Histone Lysine Methylation Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Somite Development Peptidyl-lysine Methylation Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Gene Silencing Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process ER-nucleus Signaling Pathway Regulation Of Gene Expression Cellular Response To Oxygen Levels Signal Transduction By P53 Class Mediator Regulation Of Body Fluid Levels Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Histone Acetylation Segmentation
Tagcloud ?		accomplish ash2l assembled assembles catalyzes confer dimethylation dpy enzymatic evolutionary evolved h3k4 inputs metazoan methyltransferases missing mll1 mll3 monomethtranferase monomethylation mutagenesis rbbp5 reconstituted set1 substitutions trimethylation trithorax wdr5 wrad