SETD1A and DPY30

Number of citations of the paper that reports this interaction (PMID 23870121)
8

Data Source:
BioGRID (pull down, affinity chromatography technology)

		SETD1A	DPY30
Gene Name		SET domain containing 1A	dpy-30 homolog (C. elegans)
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nuclear Speck Histone Methyltransferase Complex Set1C/COMPASS Complex	Nucleus Nucleoplasm Golgi Apparatus Trans-Golgi Network Histone Methyltransferase Complex Set1C/COMPASS Complex
	Molecular Function	Nucleotide Binding RNA Binding Protein Binding Histone Methyltransferase Activity (H3-K4 Specific)	Protein Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Chromatin Organization Transcription, DNA-templated Regulation Of Transcription, DNA-templated Stem Cell Maintenance Histone H3-K4 Methylation Positive Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Stem Cell Proliferation	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Endosomal Transport Histone H3-K4 Methylation
Pathways		Chromatin modifying enzymes Chromatin organization PKMTs methylate histone lysines
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: DPY30 EP300 HIST1H3A HIST2H3C LBP TP53 WDR5	10 interactors: ARFGEF1 ASH2L CHMP2B DYDC1 GTF2I HIST3H3 PRPF3 PSMD14 SETD1A TMCC2
Entrez ID		9739	84661
HPRD ID		13795	17434
Ensembl ID		ENSG00000099381
Uniprot IDs		O15047	B4DIS3 Q9C005
PDB IDs		3S8S 3UVN 4EWR	3G36
Enriched GO Terms of Interacting Partners?		Chromatin Organization Chromosome Organization Methylation DNA Methylation On Cytosine Chromatin Silencing At RDNA Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Histone H3-K4 Methylation Peptidyl-lysine Modification Chromatin Silencing Gene Expression Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Protein Deacetylation Histone H4 Acetylation DNA Methylation Negative Regulation Of Transcription, DNA-templated Histone Modification Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Blood Coagulation Hemostasis Negative Regulation Of Gene Expression, Epigenetic Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Somitogenesis Regulation Of RNA Metabolic Process DNA Modification Negative Regulation Of Gene Expression Histone H2B Acetylation Nucleobase-containing Compound Metabolic Process Histone Lysine Methylation Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Somite Development Peptidyl-lysine Methylation Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Gene Silencing Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process ER-nucleus Signaling Pathway Regulation Of Gene Expression Cellular Response To Oxygen Levels Signal Transduction By P53 Class Mediator Regulation Of Body Fluid Levels Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Histone Acetylation Segmentation	Histone H3-K4 Methylation Chromosome Organization Positive Regulation Of Protein Glycosylation In Golgi Histone Lysine Methylation Peptidyl-lysine Methylation Transition Between Slow And Fast Fiber Histone Methylation Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Positive Regulation Of Protein Glycosylation Cellular Aromatic Compound Metabolic Process Protein Methylation Organelle Organization Cellular Nitrogen Compound Metabolic Process Viral Budding Via Host ESCRT Complex Gene Expression Nitrogen Compound Metabolic Process Regulation Of Skeletal Muscle Adaptation Regulation Of Mitotic Spindle Assembly Negative Regulation Of Cytosolic Calcium Ion Concentration Viral Budding Peptidyl-lysine Modification Regulation Of Spindle Assembly Regulation Of Protein Glycosylation Regulation Of Mitotic Spindle Organization Negative Regulation Of Rho GTPase Activity Spliceosomal Tri-snRNP Complex Assembly Positive Regulation Of Glycoprotein Biosynthetic Process Regulation Of Protein Complex Assembly Positive Regulation Of Glycoprotein Metabolic Process Protein K63-linked Deubiquitination Cell Separation After Cytokinesis
Tagcloud ?		accomplish ash2l assembled assembles catalyzes confer dimethylation dpy enzymatic evolutionary evolved h3k4 inputs metazoan methyltransferases missing mll1 mll3 monomethtranferase monomethylation mutagenesis rbbp5 reconstituted set1 substitutions trimethylation trithorax wdr5 wrad	acidic allosterically ash2l box compass composed concave erythroid forming heterodimer interface kmt2 lysine methyltransferase methyltransferases mll1 mutational rbbp5 referred ryanodine set1 spia spry stimulates switch trithorax trxg wdr5 wrad
Tagcloud (Difference) ?		accomplish assembled assembles catalyzes confer dimethylation dpy enzymatic evolutionary evolved h3k4 inputs metazoan missing mll3 monomethtranferase monomethylation mutagenesis reconstituted substitutions trimethylation	acidic allosterically box compass composed concave erythroid forming heterodimer interface kmt2 lysine methyltransferase mutational referred ryanodine spia spry stimulates switch trxg
Tagcloud (Intersection) ?		ash2l methyltransferases mll1 rbbp5 set1 trithorax wdr5 wrad