BRPF1 and GTF2H1

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		BRPF1	GTF2H1
Gene Name		bromodomain and PHD finger containing, 1	general transcription factor IIH, polypeptide 1, 62kDa
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm MOZ/MORF Histone Acetyltransferase Complex	Core TFIIH Complex Nucleoplasm Holo TFIIH Complex
	Molecular Function	DNA Binding Protein Binding Zinc Ion Binding	Protein Kinase Activity Protein Binding DNA-dependent ATPase Activity RNA Polymerase II Carboxy-terminal Domain Kinase Activity
	Biological Process	Chromatin Organization Transcription, DNA-templated Histone H3 Acetylation Positive Regulation Of Transcription, DNA-templated	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Nucleotide-excision Repair, DNA Damage Removal DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping Protein Phosphorylation Gene Expression Viral Process Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Viral Transcription
Pathways		Chromatin modifying enzymes Chromatin organization HATs acetylate histones	RNA Polymerase II Promoter Escape Formation of HIV-1 elongation complex containing HIV-1 Tat Nucleotide Excision Repair RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Chain Elongation RNA Polymerase II Transcription RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Clearance HIV Infection Formation of the Early Elongation Complex Tat-mediated elongation of the HIV-1 transcript Formation of transcription-coupled NER (TC-NER) repair complex RNA Pol II CTD phosphorylation and interaction with CE RNA Polymerase II Pre-transcription Events Dual incision reaction in TC-NER NoRC negatively regulates rRNA expression HIV Transcription Initiation HIV Life Cycle RNA Pol II CTD phosphorylation and interaction with CE RNA Polymerase II HIV Promoter Escape HIV Transcription Elongation Dual incision reaction in GG-NER mRNA Capping RNA Polymerase I Transcription RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression Late Phase of HIV Life Cycle Formation of RNA Pol II elongation complex Global Genomic NER (GG-NER) RNA Polymerase II Transcription Initiation And Promoter Clearance Transcription-coupled NER (TC-NER) Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex Formation of incision complex in GG-NER RNA Polymerase II Transcription Initiation Transcription of the HIV genome RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS			Amyloid A Levels ( 21124955) Pancreatic cancer ( 23180869)
Protein-Protein Interactions		4 interactors: GTF2H1 HIST2H3C MEAF6 PBXIP1	42 interactors: ACTN1 AR ATF7IP BRPF1 CCNH CCSER2 CDK7 CTD E2F1 ERCC2 ERCC3 ERCC4 ERCC5 ESR1 FUBP1 GTF2E1 GTF2E2 GTF2H2 GTF2H3 HNF4A HNRNPU HOXC11 JDP2 KIF13A KPNA3 MCM2 MMS19 PIK3R1 PLCG1 POU2AF1 PSMC2 RAD23A REEP5 RXRB TNIP1 TP53 TRIOBP TXNRD2 USHBP1 XPA XPC ZSCAN1
Entrez ID		7862	2965
HPRD ID		03875	01807
Ensembl ID		ENSG00000156983	ENSG00000110768
Uniprot IDs		P55201	P32780
PDB IDs		2D9E 2RS9 2X35 2X4W 2X4X 2X4Y 3L42 3MO8	1PFJ 2DII 2RNR
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Gene Expression, Epigenetic Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression Histone H3-K14 Acetylation Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Histone H4-K12 Acetylation Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process DNA Methylation On Cytosine Histone H4-K5 Acetylation Histone H4-K8 Acetylation Histone H2A Acetylation Chromatin Silencing At RDNA Nucleotide-excision Repair, DNA Damage Removal Termination Of RNA Polymerase I Transcription Transcription Elongation From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter 7-methylguanosine MRNA Capping Transcription From RNA Polymerase I Promoter Chromatin Silencing 7-methylguanosine RNA Capping Transcription-coupled Nucleotide-excision Repair Histone H3 Acetylation Positive Regulation Of Viral Transcription Histone H4 Acetylation Regulation Of Metabolic Process DNA Methylation Transcription Elongation From RNA Polymerase II Promoter Gene Expression DNA Metabolic Process Regulation Of Viral Transcription Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Viral Process DNA-templated Transcription, Termination Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process DNA-templated Transcription, Elongation DNA Modification Nucleotide-excision Repair Gene Silencing Negative Regulation Of Biosynthetic Process Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Histone Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation	Nucleotide-excision Repair, DNA Damage Removal Nucleotide-excision Repair Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Transcription-coupled Nucleotide-excision Repair Viral Process Cellular Response To DNA Damage Stimulus Transcription From RNA Polymerase II Promoter DNA Catabolic Process Transcription Elongation From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription, DNA-templated Positive Regulation Of Gene Expression Response To UV Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA-templated Transcription, Elongation Positive Regulation Of Cellular Biosynthetic Process RNA Biosynthetic Process Termination Of RNA Polymerase I Transcription Gene Expression Transcription Elongation From RNA Polymerase I Promoter Nitrogen Compound Metabolic Process DNA Repair Transcription Initiation From RNA Polymerase I Promoter Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated 7-methylguanosine MRNA Capping Transcription From RNA Polymerase I Promoter 7-methylguanosine RNA Capping Positive Regulation Of Viral Process DNA Metabolic Process RNA Metabolic Process Cellular Response To Stress Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Viral Transcription Regulation Of Viral Process Nucleotide-excision Repair, DNA Incision Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Regulation Of Viral Transcription Response To Stress
Tagcloud ?		acetylates acetyllysine bonding bromodomain calculate directs discrete energies finger h2a h2ak5ac h2b h3k14ac h4k12ac hat heaf6 histones ing5 monocytic moz outline perturbation phd pocket quaternary selects tails titration translationally
Tagcloud (Difference) ?		acetylates acetyllysine bonding bromodomain calculate directs discrete energies finger h2a h2ak5ac h2b h3k14ac h4k12ac hat heaf6 histones ing5 monocytic moz outline perturbation phd pocket quaternary selects tails titration translationally
Tagcloud (Intersection) ?