NSD2 and H19

Number of citations of the paper that reports this interaction (PubMedID 37298108)
45

Data Source:
BioGRID (unspecified method)

		NSD2	H19
Description		nuclear receptor binding SET domain protein 2	H19 imprinted maternally expressed transcript
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm
	Molecular Function	DNA Binding Chromatin Binding Protein Binding Methyltransferase Activity Zinc Ion Binding Transferase Activity Histone Methyltransferase Activity Histone H4K20 Methyltransferase Activity Sequence-specific DNA Binding Metal Ion Binding Histone H3K36 Methyltransferase Activity Histone H3 Methyltransferase Activity Histone H3K36 Dimethyltransferase Activity Histone H3K36 Trimethyltransferase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Membranous Septum Morphogenesis Atrial Septum Primum Morphogenesis Atrial Septum Secundum Morphogenesis Double-strand Break Repair Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Methylation Positive Regulation Of Isotype Switching To IgA Isotypes Bone Development Regulation Of Establishment Of Protein Localization Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways		PKMTs methylate histone lysines Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint
Drugs
Diseases		Multiple myeloma	Russell-Silver syndrome; Silver-Russell syndrome Beckwith-Wiedemann syndrome
GWAS		Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189)	Celiac disease ( 23936387) Creatinine levels ( 29403010) Diastolic blood pressure ( 27841878) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) DNA methylation (parent-of-origin) ( 23725790) DNA methylation (variation) ( 23725790) Estimated glomerular filtration rate ( 30604766) Glomerular filtration rate ( 29403010) Hypertension ( 30487518) Pulse pressure ( 27841878) Squamous cell lung carcinoma ( 28604730) Systolic blood pressure ( 27841878 28135244) Systolic blood pressure (cigarette smoking interaction) ( 29455858)
Interacting Genes		15 interacting genes: AGO2 APP AR AURKA BRCA1 ESR1 H19 H3-4 H3C1 H3C14 HORMAD2 MDC1 PCNA PLEKHF2 TP53	21 interacting genes: BCLAF1 DDX5 DSP ESRP1 FMR1 IFIT5 ILF2 MYO1D NSD2 PCCA PCCB PPP1R3E PRKRA SERBP1 SRSF10 SRSF8 SRSF9 SSB STON2 TPM1 U2SURP
Entrez ID		7468	283120
HPRD ID		04259
Ensembl ID		ENSG00000109685	ENSG00000130600
Uniprot IDs		O96028
PDB IDs		5LSU 5VC8 6UE6 6XCG 7CRO 7E8D 7LMT 7MDN 7VLN 9EXW 9EXX 9EXY 9GBF
Enriched GO Terms of Interacting Partners?		Chromatin Organization Nucleoplasm Enzyme Binding Chromatin Remodeling Chromatin Binding Regulation Of MiRNA Transcription Protein Heterodimerization Activity Regulation Of MiRNA Metabolic Process Molecular Function Activator Activity Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Coactivator Binding Developmental Growth Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Regulation Of Reproductive Process Prostate Gland Growth Nuclear Body Mitotic DNA Damage Checkpoint Signaling Protein-DNA Complex Assembly Estrogen Response Element Binding Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of Biosynthetic Process Chromosome Positive Regulation Of Reproductive Process Nucleus Macromolecule Metabolic Process Structural Constituent Of Chromatin Protein-containing Complex Cellular Response To Estrogen Stimulus Mammary Gland Alveolus Development Positive Regulation Of Nucleobase-containing Compound Metabolic Process Core Promoter Sequence-specific DNA Binding Nucleic Acid Metabolic Process DNA Damage Checkpoint Signaling Negative Regulation Of Macromolecule Metabolic Process Regulation Of Mitotic Cell Cycle Positive Regulation Of Macromolecule Metabolic Process Epigenetic Regulation Of Gene Expression Nucleosome Assembly DNA Binding Regulation Of Cellular Response To Stress Gene Expression Prostate Gland Epithelium Morphogenesis Estrogen Receptor Signaling Pathway Nuclear Steroid Receptor Activity Cellular Response To Oxygen-containing Compound Protein-containing Complex Assembly Positive Regulation Of Transcription By RNA Polymerase II	RNA Binding Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Binding Regulation Of RNA Splicing Nucleic Acid Binding Regulation Of MRNA Splicing, Via Spliceosome RNA Processing Regulation Of MRNA Processing Propionyl-CoA Carboxylase Activity Regulation Of MRNA Metabolic Process Poly(U) RNA Binding RNA Splicing MRNA Metabolic Process MRNA Processing Short-chain Fatty Acid Catabolic Process Ribonucleoprotein Complex SiRNA Binding Sequence-specific MRNA Binding Nuclear Speck Translation Repressor Activity Short-chain Fatty Acid Metabolic Process Nuclear-transcribed MRNA Catabolic Process Negative Regulation Of Gene Expression Regulation Of Viral Life Cycle Catalytic Complex Negative Regulation Of MRNA Splicing, Via Spliceosome Branched-chain Amino Acid Metabolic Process MRNA Catabolic Process Negative Regulation Of RNA Splicing MRNA 3'-UTR Binding Regulation Of Viral Process Negative Regulation Of Macromolecule Biosynthetic Process Nucleolus MRNA Splice Site Recognition MiRNA Processing Negative Regulation Of Biosynthetic Process RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process MiRNA Transcription Positive Regulation Of Intracellular Transport Of Viral Material Ligase Activity, Forming Carbon-carbon Bonds Nuclear Histone MRNA Catabolic Process Positive Regulation Of Heart Rate By Epinephrine Regulation Of Inner Ear Auditory Receptor Cell Fate Specification Ventricular Cardiac Muscle Tissue Morphogenesis Regulation Of Primary Metabolic Process RNA Catabolic Process Nucleic Acid Metabolic Process Protein-RNA Complex Assembly Negative Regulation Of Macromolecule Metabolic Process
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