NSD2 and PLEKHF2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NSD2	PLEKHF2
Description		nuclear receptor binding SET domain protein 2	pleckstrin homology and FYVE domain containing 2
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm	Endosome Early Endosome Endoplasmic Reticulum Endomembrane System Membrane Transport Vesicle Cytoplasmic Vesicle Early Endosome Membrane
	Molecular Function	DNA Binding Chromatin Binding Protein Binding Methyltransferase Activity Zinc Ion Binding Transferase Activity Histone Methyltransferase Activity Histone H4K20 Methyltransferase Activity Sequence-specific DNA Binding Metal Ion Binding Histone H3K36 Methyltransferase Activity Histone H3 Methyltransferase Activity Histone H3K36 Dimethyltransferase Activity Histone H3K36 Trimethyltransferase Activity	Protein Binding Zinc Ion Binding Phosphatidylinositol Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Membranous Septum Morphogenesis Atrial Septum Primum Morphogenesis Atrial Septum Secundum Morphogenesis Double-strand Break Repair Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Methylation Positive Regulation Of Isotype Switching To IgA Isotypes Bone Development Regulation Of Establishment Of Protein Localization Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Endosome Organization Endosome To Lysosome Transport Protein Transport
Pathways		PKMTs methylate histone lysines Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint
Drugs
Diseases		Multiple myeloma
GWAS		Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189)	Radiation response ( 20923822)
Interacting Genes		15 interacting genes: AGO2 APP AR AURKA BRCA1 ESR1 H19 H3-4 H3C1 H3C14 HORMAD2 MDC1 PCNA PLEKHF2 TP53	168 interacting genes: ABCG4 ACY3 ADAP1 AIDA AIMP2 ANO9 APP APPL1 ARID4B ARL14EP ASPH BARHL2 BCAS2 BCAS3 BEND7 BLOC1S6 BOD1 BRD7 BSCL2 C1orf35 C3 CAVIN2 CBX8 CCDC146 CCDC172 CCDC25 CCDC85B CDC20B CEP44 CERK CGGBP1 CHCHD2 CHIC2 COX5B CRYBA1 DAZAP2 DMRT3 DNAAF11 DOCK2 DOCK3 DPPA4 DRAP1 DTX2 DUSP4 DUT EIF3C EML2 EXOC7 FAH FBXO28 FBXW5 FGF13 FHL3 FLNA FRMD8 GAGE12G GAGE2E GEM GFER GLUL GNMT GPBP1 GPBP1L1 GRAMD4 GTPBP2 HEBP2 HSPB7 INO80 KCNAB3 KCNJ5-AS1 KRTAP10-10 KRTAP5-4 L3MBTL3 LDOC1 MAGI2 MAP2K1 MAX MBIP MBP MEAF6 MFAP1 MIDN MPP4 MRI1 NDUFA5 NFIA NONO NPM2 NSD2 NUDT2 NUTM1 P2RX7 PACSIN1 PAK1IP1 PDK4 PIK3R3 PPCDC PPP1R18 PRDM14 PRKAG1 PRKAR1A PRPSAP1 PTPN3 PWWP2A RAB28 RABAC1 RADX RARA RASGEF1B RGS10 RGS8 RPAP2 RPE RPRM RPS21 RSPO2 RTN1 RTN3 RTN4 S100A1 S100A13 SAMD11 SCYL1 SEC14L4 SEPTIN2 SEPTIN5 SEPTIN6 SETBP1 SFN SNRNP35 SOST SPATA24 SPEF1 SPON2 STAMBPL1 SYT16 TBCEL TBX3 TCEANC THAP10 THG1L TNFAIP8 TNFAIP8L1 TP53BP2 TRAF6 TRAM1L1 TRAPPC3 TRIAP1 TRIM22 TSC22D3 TTC9C TXNL4B UBE2Z UGP2 USF1 XCR1 XRN2 YIF1A YY1 ZBTB6 ZDHHC24 ZFYVE26 ZNF165 ZNF250 ZNF263 ZNF398 ZNF439 ZNF581
Entrez ID		7468	79666
HPRD ID		04259	15147
Ensembl ID		ENSG00000109685	ENSG00000175895
Uniprot IDs		O96028	Q9H8W4
PDB IDs		5LSU 5VC8 6UE6 6XCG 7CRO 7E8D 7LMT 7MDN 7VLN 9EXW 9EXX 9EXY 9GBF
Enriched GO Terms of Interacting Partners?		Chromatin Organization Nucleoplasm Enzyme Binding Chromatin Remodeling Chromatin Binding Regulation Of MiRNA Transcription Protein Heterodimerization Activity Regulation Of MiRNA Metabolic Process Molecular Function Activator Activity Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Coactivator Binding Developmental Growth Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Regulation Of Reproductive Process Prostate Gland Growth Nuclear Body Mitotic DNA Damage Checkpoint Signaling Protein-DNA Complex Assembly Estrogen Response Element Binding Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of Biosynthetic Process Chromosome Positive Regulation Of Reproductive Process Nucleus Macromolecule Metabolic Process Structural Constituent Of Chromatin Protein-containing Complex Cellular Response To Estrogen Stimulus Mammary Gland Alveolus Development Positive Regulation Of Nucleobase-containing Compound Metabolic Process Core Promoter Sequence-specific DNA Binding Nucleic Acid Metabolic Process DNA Damage Checkpoint Signaling Negative Regulation Of Macromolecule Metabolic Process Regulation Of Mitotic Cell Cycle Positive Regulation Of Macromolecule Metabolic Process Epigenetic Regulation Of Gene Expression Nucleosome Assembly DNA Binding Regulation Of Cellular Response To Stress Gene Expression Prostate Gland Epithelium Morphogenesis Estrogen Receptor Signaling Pathway Nuclear Steroid Receptor Activity Cellular Response To Oxygen-containing Compound Protein-containing Complex Assembly Positive Regulation Of Transcription By RNA Polymerase II	Protein Binding Identical Protein Binding Endoplasmic Reticulum Tubular Network Formation
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