STAT6 and STAT2

Number of citations of the paper that reports this interaction (PubMedID 10490982)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		STAT6	STAT2
Description		signal transducer and activator of transcription 6	signal transducer and activator of transcription 2
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol RNA Polymerase II Transcription Regulator Complex	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane ISGF3 Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coactivator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Phosphatase Binding Identical Protein Binding Sequence-specific DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Ubiquitin-like Protein Ligase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II T-helper 1 Cell Lineage Commitment Negative Regulation Of Type 2 Immune Response Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Defense Response Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Gene Expression Cytokine-mediated Signaling Pathway Mammary Gland Epithelial Cell Proliferation Interleukin-4-mediated Signaling Pathway Regulation Of Cell Population Proliferation Response To Peptide Hormone Positive Regulation Of Transcription By RNA Polymerase II Isotype Switching To IgE Isotypes Positive Regulation Of Isotype Switching To IgE Isotypes Growth Hormone Receptor Signaling Pathway Via JAK-STAT Mammary Gland Morphogenesis Regulation Of Mast Cell Proliferation Positive Regulation Of Cold-induced Thermogenesis	Regulation Of Protein Phosphorylation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Defense Response Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Cell Population Proliferation Response To Peptide Hormone Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Virus Type I Interferon-mediated Signaling Pathway Negative Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Mitochondrial Fission
Pathways		Downstream signal transduction STAT6-mediated induction of chemokines Interleukin-4 and Interleukin-13 signaling	Interleukin-20 family signaling Interferon alpha/beta signaling Regulation of IFNA/IFNB signaling Regulation of IFNA/IFNB signaling Potential therapeutics for SARS SARS-CoV-2 activates/modulates innate and adaptive immune responses Evasion by RSV of host interferon responses
Drugs
Diseases
GWAS		Adult asthma ( 30787307) Alcohol consumption ( 31358974) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 31361310) Allergic sensitization ( 30013184 23817571) Allergy ( 27182965) Asthma ( 31619474 31361310 31959851 30929738 32296059 29273806 34103634 27182965) Asthma (adult onset) ( 30929738 31036433) Asthma (childhood onset) ( 31036433 30929738) Asthma (moderate or severe) ( 30552067) Asthma onset (childhood vs adult) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Bipolar disorder ( 31043756) Bitter alcoholic beverage consumption ( 31046077) Eosinophil count ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Eosinophilic esophagitis ( 25407941) Eosinophilic esophagitis (pediatric) ( 20208534) Familial lung cancer ( 29924316) Headache ( 29397368) Height ( 31562340) IgE levels ( 22075330) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Medication use (adrenergics, inhalants) ( 31015401) Medication use (anti-inflammatory and antirheumatic products, non-steroids) ( 31015401) Medication use (antihistamines for systemic use) ( 31015401) Migraine ( 27322543) Migraine without aura ( 27322543) Mosquito bite size ( 28199695) Neutrophil percentage of granulocytes ( 27863252) Perceived unattractiveness to mosquitoes ( 28199695) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656) Sensory disturbances after bilateral sagittal split ramus osteotomy ( 23834954) Sum eosinophil basophil counts ( 27863252)	Axial length ( 24144296) Height ( 20881960 23456168 25429064) Inflammatory skin disease ( 25574825) Lymphocyte percentage of white cells ( 32888494) Macular thickness ( 30535121) Psoriasis ( 19169254 23143594 25574825 25903422) Psoriasis vulgaris ( 26626624) Psoriatic arthritis ( 26626624) Refractive error ( 32231278)
Interacting Genes		39 interacting genes: ANKZF1 ANXA2 CEBPB CEBPE CEBPZ CREBBP DAZAP2 EEF1A1 EP300 ETS1 FBXO7 H3C14 IFNG IL4R IRF4 JAK1 LITAF NCOA1 NCOA2 NFKB1 NMI PKNOX1 PPARG PRKCZ PTPN6 RCN3 RELA RLIM SND1 SRC STAT2 STAT3 TP53 TRIM24 VKORC1 WWP1 ZBTB2 ZNF407 ZNF92	22 interacting genes: AURKA CREBBP CXCR4 DOK4 EGFR EP300 FNTA GAA GSK3A GSK3B HDAC1 IFNAR1 IFNAR2 IRF9 IWS1 JAK1 JAK2 MED14 SMARCA4 STAT1 STAT6 TYK2
Entrez ID		6778	6773
HPRD ID		03302	02778
Ensembl ID		ENSG00000166888	ENSG00000170581
Uniprot IDs		A8K4S9 B4DQB3 P42226	A0A494C164 P52630 R9QE65
PDB IDs		1OJ5 4Y5U 4Y5W 5D39 5NWM 5NWX 9BIG	2KA4 6UX2 6WCZ 8T12 8T13
Enriched GO Terms of Interacting Partners?		Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Transcription By RNA Polymerase II Chromatin Regulation Of Immune System Process Nucleobase-containing Compound Biosynthetic Process Chromatin Binding Nucleus RNA Polymerase II Transcription Regulator Complex Macromolecule Biosynthetic Process Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Defense Response Transcription Regulator Complex RNA Metabolic Process Positive Regulation Of Gene Expression Negative Regulation Of RNA Metabolic Process Positive Regulation Of Defense Response MRNA Transcription DNA Binding Positive Regulation Of MiRNA Metabolic Process T Cell Lineage Commitment Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Multicellular Organismal Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process T-helper 17 Cell Lineage Commitment DNA-binding Transcription Factor Activity Negative Regulation Of Biosynthetic Process	Cell Surface Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Protein Localization To Nucleus Positive Regulation Of Protein Localization To Nucleus Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Localization Interferon-mediated Signaling Pathway Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Transcription By RNA Polymerase II Type II Interferon-mediated Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Regulation Of Protein Localization Type I Interferon-mediated Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Signal Transduction Regulation Of RNA Metabolic Process Response To Virus Regulation Of Signal Transduction Growth Hormone Receptor Signaling Pathway Cytokine-mediated Signaling Pathway P53 Binding Cellular Response To Cytokine Stimulus Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of DNA-templated Transcription Cellular Response To Virus Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cellular Response To Interleukin-3 Positive Regulation Of Metabolic Process Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Growth Hormone Receptor Binding Response To Cytokine Tau Protein Binding Response To Peptide Regulation Of Primary Metabolic Process Positive Regulation Of Receptor Signaling Pathway Via STAT Positive Regulation Of RNA Metabolic Process Transcription Coactivator Binding Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Developmental Process Regulation Of Cellular Response To Heat Chromatin Remodeling Regulation Of Metabolic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?