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CLTC and OPTN
Number of citations of the paper that reports this interaction (PubMedID
23414517
)
48
Data Source:
BioGRID
(two hybrid)
CLTC
OPTN
Description
clathrin heavy chain
optineurin
Image
GO Annotations
Cellular Component
Cytoplasm
Lysosome
Endosome
Trans-Golgi Network
Spindle
Cytosol
Cytoskeleton
Plasma Membrane
Clathrin-coated Pit
Focal Adhesion
Membrane
Clathrin Coat
Clathrin Coat Of Trans-Golgi Network Vesicle
Clathrin Coat Of Coated Pit
Clathrin-coated Vesicle
Cytoplasmic Vesicle Membrane
Clathrin-coated Endocytic Vesicle Membrane
Cytoplasmic Vesicle
Trans-Golgi Network Membrane
Protein-containing Complex
Centriolar Satellite
Endolysosome Membrane
Melanosome
Clathrin-coated Endocytic Vesicle
Extracellular Exosome
Clathrin Complex
Mitotic Spindle
Extracellular Vesicle
Mitotic Spindle Microtubule
Golgi Membrane
Nucleus
Nucleoplasm
Cytoplasm
Endosome
Autophagosome
Golgi Apparatus
Trans-Golgi Network
Cytosol
Cytoplasmic Vesicle
Perinuclear Region Of Cytoplasm
Recycling Endosome
Recycling Endosome Membrane
Molecular Function
RNA Binding
Double-stranded RNA Binding
Structural Molecule Activity
Protein Binding
Protein Kinase Binding
Clathrin Light Chain Binding
Low-density Lipoprotein Particle Receptor Binding
Disordered Domain Specific Binding
Ubiquitin-specific Protease Binding
Protein Binding
Zinc Ion Binding
Protein-macromolecule Adaptor Activity
Polyubiquitin Modification-dependent Protein Binding
Identical Protein Binding
Metal Ion Binding
K63-linked Polyubiquitin Modification-dependent Protein Binding
Biological Process
Mitotic Cell Cycle
Osteoblast Differentiation
Intracellular Protein Transport
Receptor-mediated Endocytosis
Autophagy
Vesicle-mediated Transport
Receptor Internalization
Transferrin Transport
Retrograde Transport, Endosome To Golgi
Clathrin Coat Assembly
Cell Division
Regulation Of Mitotic Spindle Organization
Clathrin Coat Disassembly
Clathrin-dependent Endocytosis
Amyloid-beta Clearance By Transcytosis
Negative Regulation Of Hyaluronan Biosynthetic Process
Negative Regulation Of Protein Localization To Plasma Membrane
Negative Regulation Of Receptor Recycling
Immune System Process
Autophagy
Golgi Organization
Signal Transduction
Intracellular Protein Localization
Cell Death
Positive Regulation Of Autophagy
Protein Localization To Golgi Apparatus
Cellular Response To Unfolded Protein
Golgi To Plasma Membrane Protein Transport
Regulation Of Canonical NF-kappaB Signal Transduction
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Innate Immune Response
Defense Response To Gram-negative Bacterium
Type 2 Mitophagy
Golgi Ribbon Formation
Positive Regulation Of Xenophagy
Pathways
Entry of Influenza Virion into Host Cell via Endocytosis
Retrograde neurotrophin signalling
Retrograde neurotrophin signalling
Gap junction degradation
Formation of annular gap junctions
MHC class II antigen presentation
EPH-ephrin mediated repulsion of cells
Lysosome Vesicle Biogenesis
Recycling pathway of L1
Recycling pathway of L1
WNT5A-dependent internalization of FZD4
WNT5A-dependent internalization of FZD2, FZD5 and ROR2
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
VLDLR internalisation and degradation
LDL clearance
RHOU GTPase cycle
RHOV GTPase cycle
ALK mutants bind TKIs
Signaling by ALK fusions and activated point mutants
Regulation of PLK1 Activity at G2/M Transition
PINK1-PRKN Mediated Mitophagy
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
TNFR1-induced NF-kappa-B signaling pathway
TBC/RABGAPs
TICAM1-dependent activation of IRF3/IRF7
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation
Drugs
Diseases
Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
Primary open angle glaucoma
GWAS
Cerebrospinal fluid p-tau levels (
29274321
)
Cerebrospinal fluid p-tau levels in mild cognitive impairment (
29274321
)
Paget's disease (
20436471
21623375
)
Interacting Genes
70 interacting genes:
ACO1
AFTPH
AMPH
ANXA1
AP1B1
AP1G1
AP3B1
AP3B2
ARF6
ARMCX3
ARR3
ARRB1
ARRB2
BTG3
C10orf88
CEBPA
CLINT1
CLTA
CLTB
DNAJC6
DSCAM
DSCR9
DUX4
EPN1
EPN2
ERG
FYN
GAK
GGA1
GGA2
GGA3
GRIN1
GRIN2D
HGS
HIP1
HIP1R
ITSN1
KIT
LDLRAP1
MAP3K10
MAU2
NCALD
NDRG1
OCRL
OPTN
PICALM
PPP1CC
PRKACA
PXN
QARS1
RIPK4
SCYL2
SMAP1
SNX5
SNX9
SPATC1L
SRC
STAMBP
SUMO2
SYNJ1
TFAP2A
TNK2
TOM1
USP7
VCL
WNK1
XRCC6
YWHAG
YWHAQ
ZFYVE9
72 interacting genes:
AIMP1
ARRDC3
ATG16L1
ATG5
CALM1
CCDC13
CDC23
CFTR
CLTC
CMYA5
DAZAP2
DYSF
DZIP1
ENTREP1
FLII
FOS
FTH1
GABARAP
GABARAPL1
GABARAPL2
GNAS
GRM1
GTF3A
HACE1
HSF2BP
HSPB1
HTT
IRAK1
KANSL1L
LITAF
LNX2
MAILR
MAP1LC3A
MAP1LC3B
MAP1LC3C
MPP1
MYH3
MYO6
PIAS4
PICK1
POU6F2
RAB11A
RAB11B
RAB12
RAB14
RAB25
RAB8A
RBM12
RFFL
RNF11
RNF216
SDCBP
SLF2
SNCA
SNX6
TBC1D15
TBC1D17
UBB
UQCRQ
USP2
VCP
WASHC3
WIPI2
WWP2
ZNF17
ZNF181
ZNF302
ZNF329
ZNF398
ZNF426
ZNF670
ZNF711
Entrez ID
1213
10133
HPRD ID
00350
03891
Ensembl ID
ENSG00000141367
ENSG00000123240
Uniprot IDs
A0A087WVQ6
Q00610
Q96CV9
PDB IDs
2XZG
4G55
6E4L
6QNN
6QNP
7BN1
7BN2
7ZX4
9C0Y
9C0Z
2LO4
2LUE
3VTV
3VTW
5AAZ
5B83
5EOA
5EOF
7CZM
9B0B
9B0Z
9B12
9IKQ
Enriched GO Terms of Interacting Partners
?
Endocytosis
Clathrin Binding
Vesicle-mediated Transport
Import Into Cell
Clathrin-coated Vesicle
Cytoplasmic Vesicle
Clathrin-coated Pit
Receptor-mediated Endocytosis
Early Endosome
Synaptic Vesicle Endocytosis
Regulation Of Vesicle-mediated Transport
Cytosol
Presynaptic Endocytosis
Endosome
Establishment Of Localization In Cell
Intracellular Transport
Regulation Of Endocytosis
Clathrin-dependent Endocytosis
Regulation Of Receptor-mediated Endocytosis
Cellular Localization
Establishment Of Protein Localization
Clathrin Vesicle Coat
Clathrin Coat Assembly
Clathrin Heavy Chain Binding
Phosphatidylinositol Binding
Protein Transport
Protein Localization To Cell Surface
Intracellular Protein Localization
Cytoplasm
Vesicle-mediated Transport In Synapse
Clathrin-coated Vesicle Membrane
Regulation Of Transport
Clathrin Coat Of Coated Pit
Early Endosome Membrane
Receptor Internalization
Intracellular Protein Transport
Golgi Apparatus
Cytoplasmic Vesicle Membrane
Presynapse
Phospholipid Binding
Regulation Of Clathrin Coat Assembly
Synaptic Vesicle Uncoating
Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Endosomal Transport
Membrane Coat
Perinuclear Region Of Cytoplasm
Protein Domain Specific Binding
Positive Regulation Of Cellular Component Organization
Clathrin Coat Disassembly
Clathrin Adaptor Activity
Autophagosome
Cellular Response To Nitrogen Starvation
Cytoplasmic Vesicle
Phosphatidylethanolamine Binding
Autophagy
Autophagosome Maturation
Endosome
Autophagosome Assembly
Ubiquitin Protein Ligase Binding
Autophagosome Organization
Autophagy Of Mitochondrion
Establishment Of Protein Localization
Macroautophagy
Protein Transport
Phospholipid Binding
Autophagosome Membrane
Vacuole Organization
Mitophagy
Myosin V Binding
Cellular Response To Starvation
Establishment Of Localization In Cell
Recycling Endosome Membrane
Protein-containing Complex Disassembly
Response To Starvation
Organelle Assembly
Intracellular Transport
Recycling Endosome
Cellular Response To Nutrient Levels
Intracellular Protein Localization
Endosomal Transport
Cellular Localization
Lysosome
Beta-tubulin Binding
Centriolar Satellite
Amyloid-beta Clearance By Transcytosis
Response To Iron(II) Ion
Regulation Of Cilium Assembly
Vesicle-mediated Transport
Cellular Response To Stress
Cytoplasmic Vesicle Membrane
Cytosol
G Protein Activity
Cytoplasm
Intracellular Protein Transport
Endocytic Recycling
Regulation Of Protein Localization
Exocytosis
Endosome Membrane
Catabolic Process
Response To Nutrient Levels
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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