CLTC and DNAJC6

Number of citations of the paper that reports this interaction (PMID 11470803)
13

Data Source:
HPRD (in vitro)

		CLTC	DNAJC6
Gene Name		clathrin, heavy chain (Hc)	DnaJ (Hsp40) homolog, subfamily C, member 6
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Spindle Cytosol Plasma Membrane Focal Adhesion Membrane Clathrin Coat Clathrin Coat Of Trans-Golgi Network Vesicle Clathrin Coat Of Coated Pit Clathrin-coated Vesicle Clathrin-coated Endocytic Vesicle Membrane Vesicle Trans-Golgi Network Membrane Melanosome Intracellular Membrane-bounded Organelle Protein Complex Extracellular Vesicular Exosome Clathrin Complex	Cytosol Synapse
	Molecular Function	Double-stranded RNA Binding Structural Molecule Activity Protein Binding Protein Kinase Binding Clathrin Light Chain Binding Poly(A) RNA Binding	Protein Tyrosine Phosphatase Activity SH3 Domain Binding
	Biological Process	Osteoblast Differentiation Intracellular Protein Transport Post-Golgi Vesicle-mediated Transport Receptor-mediated Endocytosis Mitotic Nuclear Division Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Receptor Internalization Transferrin Transport Membrane Organization Negative Regulation Of Hyaluronan Biosynthetic Process Negative Regulation Of Protein Localization To Plasma Membrane	Post-Golgi Vesicle-mediated Transport Peptidyl-tyrosine Dephosphorylation Membrane Organization Clathrin Coat Disassembly Regulation Of Clathrin-mediated Endocytosis
Pathways		Formation of annular gap junctions EPH-ephrin mediated repulsion of cells Axon guidance Gap junction degradation Gap junction trafficking and regulation Gap junction trafficking WNT5A-dependent internalization of FZD4 EPH-Ephrin signaling Signaling by Wnt PCP/CE pathway beta-catenin independent WNT signaling	Golgi Associated Vesicle Biogenesis trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding Lysosome Vesicle Biogenesis
Drugs
Diseases
GWAS			Anticoagulant levels ( 22216198)
Protein-Protein Interactions		60 interactors: AMPH AP1B1 AP1G1 AP2A2 AP2B1 AP3B1 AP3B2 ARMCX3 ARR3 ARRB1 ARRB2 C10orf88 CLINT1 CLTA CLTB DNAJC6 EHD1 EP300 EPN1 EPN2 ERG FYN GAK GGA1 GGA2 GGA3 GRIN1 GRIN2D HGS HIP1 HIP1R ITSN1 KIT LDLRAP1 MAP3K10 NCALD NDRG1 OCRL PICALM PPP1CA PPP1CC PRKACA PXN QARS SCYL2 SNX5 SNX9 SRC STAM STAMBP SYNJ1 TFAP2A TNK2 TOM1 VCL WNK1 XRCC6 YWHAG YWHAQ ZFYVE9	3 interactors: AP2A2 BAG2 CLTC
Entrez ID		1213	9829
HPRD ID		00350	16326
Ensembl ID		ENSG00000141367	ENSG00000116675
Uniprot IDs		Q00610	O75061
PDB IDs		2XZG 4G55
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Endocytosis Transport Establishment Of Localization In Cell Intracellular Transport Cellular Localization Intracellular Protein Transport Cellular Protein Localization Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Vesicle-mediated Transport ERBB Signaling Pathway Protein Transport Signaling Establishment Of Protein Localization Cell Communication Enzyme Linked Receptor Protein Signaling Pathway Protein Localization Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Endocytosis Negative Regulation Of ERBB Signaling Pathway Cellular Response To Growth Factor Stimulus Regulation Of Signaling Response To Growth Factor Membrane Organization Positive Regulation Of Transport Regulation Of Signal Transduction Negative Regulation Of Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Stimulus Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Synaptic Transmission Endosomal Transport Negative Regulation Of Signaling Post-Golgi Vesicle-mediated Transport Signal Transduction Regulation Of Defense Response To Virus By Virus Nervous System Development Receptor-mediated Endocytosis Regulation Of Cellular Component Organization Cell-cell Signaling Response To Stimulus Positive Regulation Of Receptor-mediated Endocytosis Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Receptor Internalization Regulation Of Protein Metabolic Process Cell Surface Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Positive Regulation Of Endocytosis	Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Negative Regulation Of Hyaluronan Biosynthetic Process Antigen Processing And Presentation Receptor-mediated Endocytosis Endocytosis Negative Regulation Of Protein Localization To Plasma Membrane Regulation Of Defense Response To Virus By Virus Transferrin Transport Intracellular Protein Transport Clathrin-mediated Endocytosis Receptor Internalization Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Regulation Of Protein Localization To Plasma Membrane Cellular Protein Localization Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Protein Transport Iron Ion Transport Regulation Of ERBB Signaling Pathway Receptor Metabolic Process Regulation Of Defense Response To Virus Vesicle-mediated Transport Establishment Of Protein Localization Post-Golgi Vesicle-mediated Transport Intracellular Transport Ephrin Receptor Signaling Pathway
Tagcloud ?		alk clathrin contribution deregulated diffuse dlbcl dlbcls encoding feature formed lm1 lymphoma lymphomas maintenance nanomolar nod nvp otherwise providing rationale refractory repressed scid signalling subtype sustained tae684 thereby xenotransplant	advances autosomal bring closer determinants dj exome expectation gba genetics incomplete juvenile landscape lrrk2 modulating monogenic outline parkin parkinsonism pd penetrance penetrant pink1 recessive snca synj1 technologies variants vps35
Tagcloud (Difference) ?		alk clathrin contribution deregulated diffuse dlbcl dlbcls encoding feature formed lm1 lymphoma lymphomas maintenance nanomolar nod nvp otherwise providing rationale refractory repressed scid signalling subtype sustained tae684 thereby xenotransplant	advances autosomal bring closer determinants dj exome expectation gba genetics incomplete juvenile landscape lrrk2 modulating monogenic outline parkin parkinsonism pd penetrance penetrant pink1 recessive snca synj1 technologies variants vps35
Tagcloud (Intersection) ?