CLTC and DNAJC6

Number of citations: 0 (PubMedID 11470803)
Data Source: HPRD (in vitro)

		CLTC	DNAJC6
Name		clathrin heavy chain	DnaJ heat shock protein family (Hsp40) member C6
Structure			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosome Endosome Trans-Golgi Network Spindle Cytosol Cytoskeleton Plasma Membrane Clathrin-coated Pit Focal Adhesion Membrane Clathrin Coat Clathrin Coat Of Trans-Golgi Network Vesicle Clathrin Coat Of Coated Pit Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Cytoplasmic Vesicle Trans-Golgi Network Membrane Protein-containing Complex Centriolar Satellite Endolysosome Membrane Melanosome Clathrin-coated Endocytic Vesicle Extracellular Exosome Clathrin Complex Mitotic Spindle Extracellular Vesicle Mitotic Spindle Microtubule	Cytoplasm Cytosol Postsynaptic Density Clathrin-coated Vesicle Cytoplasmic Vesicle Vesicle Intracellular Membrane-bounded Organelle Synapse Extrinsic Component Of Presynaptic Endocytic Zone Membrane
	Molecular Function	RNA Binding Double-stranded RNA Binding Structural Molecule Activity Protein Binding Protein Kinase Binding Clathrin Light Chain Binding Low-density Lipoprotein Particle Receptor Binding Disordered Domain Specific Binding Ubiquitin-specific Protease Binding	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity SH3 Domain Binding Clathrin Binding Heat Shock Protein Binding Clathrin Heavy Chain Binding
	Biological Process	Mitotic Cell Cycle Osteoblast Differentiation Intracellular Protein Transport Receptor-mediated Endocytosis Autophagy Vesicle-mediated Transport Receptor Internalization Transferrin Transport Retrograde Transport, Endosome To Golgi Clathrin Coat Assembly Cell Division Regulation Of Mitotic Spindle Organization Clathrin Coat Disassembly Clathrin-dependent Endocytosis Amyloid-beta Clearance By Transcytosis Negative Regulation Of Hyaluronan Biosynthetic Process Negative Regulation Of Protein Localization To Plasma Membrane	Synaptic Vesicle Uncoating Synaptic Vesicle Recycling Intracellular Transport Clathrin Coat Disassembly Clathrin-dependent Endocytosis Regulation Of Clathrin Coat Assembly Regulation Of Clathrin-dependent Endocytosis
Pathways		Entry of Influenza Virion into Host Cell via Endocytosis Retrograde neurotrophin signalling Retrograde neurotrophin signalling Gap junction degradation Formation of annular gap junctions MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Lysosome Vesicle Biogenesis Recycling pathway of L1 Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance RHOU GTPase cycle RHOV GTPase cycle ALK mutants bind TKIs Signaling by ALK fusions and activated point mutants	Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Clathrin-mediated endocytosis
GWAS		No GWAS studies recorded	Anticoagulant levels ( 22216198 ) Idiopathic osteonecrosis of the femoral head ( 28000841 )
Interacting Genes		70 interacting genes: ACO1 AFTPH AMPH ANXA1 AP1B1 AP1G1 AP3B1 AP3B2 ARF6 ARMCX3 ARR3 ARRB1 ARRB2 BTG3 C10orf88 CEBPA CLINT1 CLTA CLTB DNAJC6 DSCAM DSCR9 DUX4 EPN1 EPN2 ERG FYN GAK GGA1 GGA2 GGA3 GRIN1 GRIN2D HGS HIP1 HIP1R ITSN1 KIT LDLRAP1 MAP3K10 MAU2 NCALD NDRG1 OCRL OPTN PICALM PPP1CC PRKACA PXN QARS1 RIPK4 SCYL2 SMAP1 SNX5 SNX9 SPATC1L SRC STAMBP SUMO2 SYNJ1 TFAP2A TNK2 TOM1 USP7 VCL WNK1 XRCC6 YWHAG YWHAQ ZFYVE9	3 interacting genes: AP2A2 BAG2 CLTC
Entrez ID		1213	9829
HPRD ID		00350	16326
Ensembl ID		ENSG00000141367	ENSG00000116675
Uniprot IDs		A0A087WVQ6 Q00610	O75061
PDB IDs		2XZG 4G55 6E4L 6QNN 6QNP 7BN1 7BN2 7ZX4 9C0Y 9C0Z	Not available
GO Terms Enriched among Interactors		Endocytosis Clathrin Binding Vesicle-mediated Transport Import Into Cell Clathrin-coated Vesicle Cytoplasmic Vesicle Clathrin-coated Pit Receptor-mediated Endocytosis Early Endosome Synaptic Vesicle Endocytosis Regulation Of Vesicle-mediated Transport Cytosol Presynaptic Endocytosis Endosome Establishment Of Localization In Cell Intracellular Transport Regulation Of Endocytosis Clathrin-dependent Endocytosis Regulation Of Receptor-mediated Endocytosis Cellular Localization Establishment Of Protein Localization Clathrin Vesicle Coat Clathrin Coat Assembly Clathrin Heavy Chain Binding Phosphatidylinositol Binding Protein Transport Protein Localization To Cell Surface Intracellular Protein Localization Cytoplasm Vesicle-mediated Transport In Synapse Clathrin-coated Vesicle Membrane Regulation Of Transport Clathrin Coat Of Coated Pit Early Endosome Membrane Receptor Internalization Intracellular Protein Transport Golgi Apparatus Cytoplasmic Vesicle Membrane Presynapse Phospholipid Binding Regulation Of Clathrin Coat Assembly Synaptic Vesicle Uncoating Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Endosomal Transport Membrane Coat Perinuclear Region Of Cytoplasm Protein Domain Specific Binding Positive Regulation Of Cellular Component Organization Clathrin Coat Disassembly Clathrin Adaptor Activity	Endolysosome Membrane Disordered Domain Specific Binding Clathrin-coated Endocytic Vesicle Clathrin-dependent Endocytosis Clathrin-coated Endocytic Vesicle Membrane Receptor Internalization Clathrin-coated Pit Receptor-mediated Endocytosis Dendritic Microtubule Postsynaptic Neurotransmitter Receptor Internalization Clathrin Coat Of Trans-Golgi Network Vesicle Vesicle Uncoating Regulation Of Hyaluronan Biosynthetic Process Negative Regulation Of Hyaluronan Biosynthetic Process Clathrin Complex Clathrin Coat Clathrin Coat Of Coated Pit Clathrin Light Chain Binding Clathrin Coat Disassembly Amyloid-beta Clearance By Transcytosis Clathrin Adaptor Complex AP-2 Adaptor Complex Endocytosis Protein Kinase Binding Transferrin Transport Adenyl-nucleotide Exchange Factor Activity Intracellular Protein Transport Mitotic Spindle Microtubule Clathrin Adaptor Activity Transcytosis Ubiquitin-specific Protease Binding Clathrin Coat Assembly Import Into Cell Low-density Lipoprotein Particle Receptor Binding Amyloid-beta Clearance Positive Regulation Of Protein Processing Positive Regulation Of Protein Maturation Membrane Coat Negative Regulation Of Protein Localization To Plasma Membrane Protein Folding Chaperone Complex Protein Depolymerization Synaptic Vesicle Endocytosis Cytoplasmic Vesicle Presynaptic Endocytosis Regulation Of Mitotic Spindle Organization Iron Ion Transport Tau Protein Binding Ficolin-1-rich Granule Membrane Regulation Of Protein Processing Regulation Of Protein Maturation