OPTN and RAB11B

Number of citations of the paper that reports this interaction (PMID 11495908)
79

Data Source:
BioGRID (two hybrid, affinity chromatography technology)
HPRD (in vivo, in vitro)

		OPTN	RAB11B
Gene Name		optineurin	RAB11B, member RAS oncogene family
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Nucleus Nucleoplasm Cytoplasm Autophagic Vacuole Golgi Apparatus Trans-Golgi Network Cytosol Cytoplasmic Membrane-bounded Vesicle Perinuclear Region Of Cytoplasm Recycling Endosome	Mitochondrion Synaptic Vesicle Cell Junction Phagocytic Vesicle Membrane Synaptic Vesicle Membrane Phagocytic Vesicle Recycling Endosome Recycling Endosome Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Protein C-terminus Binding Rab GTPase Binding Polyubiquitin Binding K63-linked Polyubiquitin Binding	GTPase Activity Protein Binding GTP Binding GDP Binding Myosin V Binding
	Biological Process	Protein Targeting To Golgi G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Negative Regulation Of Receptor Recycling Golgi Organization Signal Transduction Cell Death Macroautophagy Golgi To Plasma Membrane Protein Transport Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Defense Response To Gram-negative Bacterium Golgi Ribbon Formation	Receptor Recycling Intracellular Protein Transport Melanosome Transport Rab Protein Signal Transduction Transferrin Transport Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of Anion Transport Constitutive Secretory Pathway Regulated Secretory Pathway Cellular Response To Acidic PH Establishment Of Protein Localization To Membrane Retrograde Transport, Endosome To Plasma Membrane Regulation Of Protein Localization To Cell Surface Regulation Of Endocytic Recycling
Pathways		G2/M Transition Mitotic G2-G2/M phases Regulation of PLK1 Activity at G2/M Transition Cell Cycle, Mitotic
Drugs
Diseases
GWAS		Paget's disease ( 21623375 20436471)
Protein-Protein Interactions		36 interactors: CALM1 CCDC53 CDC23 CYLD DAZAP2 EPS15 FAM178A FLII FOS GNAS GRM1 GTF3A HACE1 HTT MAP1LC3A MPP1 MYO6 PIAS4 RAB10 RAB11A RAB11B RAB12 RAB14 RAB25 RAB8A RNF11 SQSTM1 TBC1D15 TBC1D17 TBK1 TNIP1 UBC UQCRQ ZNF329 ZNF398 ZNF670	9 interactors: APP IKBKG MYO5B OPTN RAB11FIP1 RAB11FIP2 RAB11FIP3 RAB11FIP5 SREBF2
Entrez ID		10133	9230
HPRD ID		03891	05009
Ensembl ID		ENSG00000123240	ENSG00000185236
Uniprot IDs		Q96CV9	Q15907
PDB IDs		2LO4 2LUE 3VTV 3VTW	2F9L 2F9M
Enriched GO Terms of Interacting Partners?		Endosomal Transport Rab Protein Signal Transduction Membrane Organization Ras Protein Signal Transduction Secretion By Cell Establishment Of Localization In Cell Intracellular Transport Intracellular Signal Transduction Secretion Protein Secretion Cellular Localization Cell Communication Signal Transduction Regulation Of Signaling Protein Transport Vesicle-mediated Transport Signaling Establishment Of Protein Localization Exocytosis Protein Localization Pattern Recognition Receptor Signaling Pathway Cellular Response To Stimulus Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Small GTPase Mediated Signal Transduction Regulation Of Cellular Process Intracellular Protein Transport Positive Regulation Of Metabolic Process Positive Regulation Of Innate Immune Response Establishment Of Organelle Localization Establishment Of Vesicle Localization Vesicle Localization Cellular Protein Catabolic Process Regulation Of Vesicle-mediated Transport Melanosome Transport Regulation Of Intracellular Signal Transduction Pigment Granule Transport Regulation Of I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor Signaling Pathway Establishment Of Melanosome Localization Protein Catabolic Process Regulation Of Innate Immune Response Positive Regulation Of Cellular Metabolic Process Organelle Localization Melanosome Localization Endomembrane System Organization Golgi Vesicle Transport Negative Regulation Of Type I Interferon Production Immune Response-regulating Signaling Pathway Regulation Of Signal Transduction	Cellular Localization Vesicle-mediated Transport Regulated Secretory Pathway Establishment Of Localization In Cell Insulin Secretion Involved In Cellular Response To Glucose Stimulus Exocytosis Secretion By Cell Renal Water Homeostasis Secretion Homeostatic Process Protein Transport Establishment Of Protein Localization Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Insulin Secretion Water Transport Fluid Transport Multicellular Organismal Water Homeostasis Chemical Homeostasis Cellular Response To Glucose Stimulus Water Homeostasis Peptide Hormone Secretion Peptide Secretion Protein Localization Cellular Glucose Homeostasis Cellular Response To Carbohydrate Stimulus Transport Hormone Secretion Hormone Transport Peptide Transport Renal System Process Regulation Of Lipid Transport By Negative Regulation Of Transcription From RNA Polymerase II Promoter Synaptic Growth At Neuromuscular Junction Cholesterol Metabolic Process Cellular Chemical Homeostasis Protein Secretion Sterol Metabolic Process Amide Transport Regulation Of Body Fluid Levels Response To Glucose Collateral Sprouting In Absence Of Injury Negative Regulation Of Receptor Recycling Collateral Sprouting Axon Midline Choice Point Recognition Negative Regulation Of Cholesterol Efflux Cellular Homeostasis Response To Carbohydrate Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Intracellular Receptor Signaling Pathway Axon Choice Point Recognition Golgi Ribbon Formation
Tagcloud ?		advocate agenda ast cms comes competence consent continuum controversies educated ilda independence informed interpretive ldcop mandated maximize medicaid minimize narrow optimize procurement profession qualifications regulations skill transparent varies veto	app biology causal complemented complexity deposition endosomal exome gtpase gtpases late link membrane network players rab3 recycling retromer retromers rnai road screen secretase secretases trafficking unravel
Tagcloud (Difference) ?		advocate agenda ast cms comes competence consent continuum controversies educated ilda independence informed interpretive ldcop mandated maximize medicaid minimize narrow optimize procurement profession qualifications regulations skill transparent varies veto	app biology causal complemented complexity deposition endosomal exome gtpase gtpases late link membrane network players rab3 recycling retromer retromers rnai road screen secretase secretases trafficking unravel
Tagcloud (Intersection) ?